Micronuclei in breast aspirates. Is scoring them helpful?
Micronuclei scoring can be used as a biomarker of genotoxic and chromosomal damage. 1. To score the spontaneously occurring micronuclei in the baseline population (fibroadenomas) and infiltrating ductal carcinoma, 2. Compare micronuclei frequency in benign tumors and various grades of infiltrating d...
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| Veröffentlicht in: | Journal of cancer research and therapeutics 2014-04, Vol.10 (2), p.309-311 |
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| creator | Hemalatha, A Suresh, T N HarendraKumar, M L |
| description | Micronuclei scoring can be used as a biomarker of genotoxic and chromosomal damage.
1. To score the spontaneously occurring micronuclei in the baseline population (fibroadenomas) and infiltrating ductal carcinoma, 2. Compare micronuclei frequency in benign tumors and various grades of infiltrating ductal carcinomas.
Study was done at a tertiary hospital where 40 cases of fibroadenoma and 40 cases of infiltrating ductal carcinoma were taken up. May Grunwald Giemsa stained smears were analyzed for micronuclei scoring.
Independent sample test (Student t test) was done to look for significant difference occurring between the controls among all grades of infiltrating ductal carcinoma.
Mean micronuclei range in fibroadenoma was 1.8 ± 1.9. It was 12.1 ± 9.2, 27.4 ± 27.2 and 100 ± 36.5 in grade I, grade II and grade III carcinomas respectively.
An increase in micronuclei values was seen from fibroadenoma to infiltrating ductal carcinoma. Micronuclei scoring can be used as a biomarker on fine needle aspiration cytology smears of breast carcinoma. |
| doi_str_mv | 10.4103/0973-1482.136588 |
| format | Article |
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1. To score the spontaneously occurring micronuclei in the baseline population (fibroadenomas) and infiltrating ductal carcinoma, 2. Compare micronuclei frequency in benign tumors and various grades of infiltrating ductal carcinomas.
Study was done at a tertiary hospital where 40 cases of fibroadenoma and 40 cases of infiltrating ductal carcinoma were taken up. May Grunwald Giemsa stained smears were analyzed for micronuclei scoring.
Independent sample test (Student t test) was done to look for significant difference occurring between the controls among all grades of infiltrating ductal carcinoma.
Mean micronuclei range in fibroadenoma was 1.8 ± 1.9. It was 12.1 ± 9.2, 27.4 ± 27.2 and 100 ± 36.5 in grade I, grade II and grade III carcinomas respectively.
An increase in micronuclei values was seen from fibroadenoma to infiltrating ductal carcinoma. Micronuclei scoring can be used as a biomarker on fine needle aspiration cytology smears of breast carcinoma.</description><identifier>ISSN: 0973-1482</identifier><identifier>EISSN: 1998-4138</identifier><identifier>DOI: 10.4103/0973-1482.136588</identifier><identifier>PMID: 25022383</identifier><language>eng</language><publisher>India: Medknow Publications & Media Pvt. Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biopsy, Fine-Needle ; Breast - pathology ; Breast Neoplasms - pathology ; Carcinoma, Ductal, Breast - pathology ; Female ; Humans ; Micronuclei, Chromosome-Defective ; Middle Aged ; Retrospective Studies ; Rural Population ; Young Adult</subject><ispartof>Journal of cancer research and therapeutics, 2014-04, Vol.10 (2), p.309-311</ispartof><rights>Copyright Medknow Publications & Media Pvt Ltd Apr-Jun 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369t-52b2c3487d1b99ba0235836fd395f01c1c33bc253b143e68f1824f508580980d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25022383$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hemalatha, A</creatorcontrib><creatorcontrib>Suresh, T N</creatorcontrib><creatorcontrib>HarendraKumar, M L</creatorcontrib><title>Micronuclei in breast aspirates. Is scoring them helpful?</title><title>Journal of cancer research and therapeutics</title><addtitle>J Cancer Res Ther</addtitle><description>Micronuclei scoring can be used as a biomarker of genotoxic and chromosomal damage.
1. To score the spontaneously occurring micronuclei in the baseline population (fibroadenomas) and infiltrating ductal carcinoma, 2. Compare micronuclei frequency in benign tumors and various grades of infiltrating ductal carcinomas.
Study was done at a tertiary hospital where 40 cases of fibroadenoma and 40 cases of infiltrating ductal carcinoma were taken up. May Grunwald Giemsa stained smears were analyzed for micronuclei scoring.
Independent sample test (Student t test) was done to look for significant difference occurring between the controls among all grades of infiltrating ductal carcinoma.
Mean micronuclei range in fibroadenoma was 1.8 ± 1.9. It was 12.1 ± 9.2, 27.4 ± 27.2 and 100 ± 36.5 in grade I, grade II and grade III carcinomas respectively.
An increase in micronuclei values was seen from fibroadenoma to infiltrating ductal carcinoma. Micronuclei scoring can be used as a biomarker on fine needle aspiration cytology smears of breast carcinoma.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biopsy, Fine-Needle</subject><subject>Breast - pathology</subject><subject>Breast Neoplasms - pathology</subject><subject>Carcinoma, Ductal, Breast - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Micronuclei, Chromosome-Defective</subject><subject>Middle Aged</subject><subject>Retrospective Studies</subject><subject>Rural Population</subject><subject>Young Adult</subject><issn>0973-1482</issn><issn>1998-4138</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkD1PwzAQhi0EoqWwMyFLLCwpts9O7Amhio9KRSwwW45j01T5wk4G_j2JWjow3XDP--ruQeiakiWnBO6JyiChXLIlhVRIeYLmVCmZcAryFM2P6xm6iHFHiMgYk-doxgRhDCTMkXorbWibwVauxGWD8-BM7LGJXRlM7-ISryOOtg1l84X7ravx1lWdH6qHS3TmTRXd1WEu0Ofz08fqNdm8v6xXj5vEQqr6RLCcWeAyK2iuVG4IAyEh9QUo4Qm11ALklgnIKQeXSk8l414QKSRRkhSwQHf73i6034OLva7LaF1Vmca1Q9RUcMEpT1M-orf_0F07hGa8bqQES7NR2kSRPTU-HmNwXnehrE340ZToSauevOnJm95rHSM3h-Ihr11xDPx5hF_ism78</recordid><startdate>20140401</startdate><enddate>20140401</enddate><creator>Hemalatha, A</creator><creator>Suresh, T N</creator><creator>HarendraKumar, M L</creator><general>Medknow Publications & Media Pvt. 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Is scoring them helpful?</title><author>Hemalatha, A ; Suresh, T N ; HarendraKumar, M L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-52b2c3487d1b99ba0235836fd395f01c1c33bc253b143e68f1824f508580980d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biopsy, Fine-Needle</topic><topic>Breast - pathology</topic><topic>Breast Neoplasms - pathology</topic><topic>Carcinoma, Ductal, Breast - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Micronuclei, Chromosome-Defective</topic><topic>Middle Aged</topic><topic>Retrospective Studies</topic><topic>Rural Population</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hemalatha, A</creatorcontrib><creatorcontrib>Suresh, T N</creatorcontrib><creatorcontrib>HarendraKumar, M L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cancer research and therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hemalatha, A</au><au>Suresh, T N</au><au>HarendraKumar, M L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Micronuclei in breast aspirates. Is scoring them helpful?</atitle><jtitle>Journal of cancer research and therapeutics</jtitle><addtitle>J Cancer Res Ther</addtitle><date>2014-04-01</date><risdate>2014</risdate><volume>10</volume><issue>2</issue><spage>309</spage><epage>311</epage><pages>309-311</pages><issn>0973-1482</issn><eissn>1998-4138</eissn><abstract>Micronuclei scoring can be used as a biomarker of genotoxic and chromosomal damage.
1. To score the spontaneously occurring micronuclei in the baseline population (fibroadenomas) and infiltrating ductal carcinoma, 2. Compare micronuclei frequency in benign tumors and various grades of infiltrating ductal carcinomas.
Study was done at a tertiary hospital where 40 cases of fibroadenoma and 40 cases of infiltrating ductal carcinoma were taken up. May Grunwald Giemsa stained smears were analyzed for micronuclei scoring.
Independent sample test (Student t test) was done to look for significant difference occurring between the controls among all grades of infiltrating ductal carcinoma.
Mean micronuclei range in fibroadenoma was 1.8 ± 1.9. It was 12.1 ± 9.2, 27.4 ± 27.2 and 100 ± 36.5 in grade I, grade II and grade III carcinomas respectively.
An increase in micronuclei values was seen from fibroadenoma to infiltrating ductal carcinoma. Micronuclei scoring can be used as a biomarker on fine needle aspiration cytology smears of breast carcinoma.</abstract><cop>India</cop><pub>Medknow Publications & Media Pvt. Ltd</pub><pmid>25022383</pmid><doi>10.4103/0973-1482.136588</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of cancer research and therapeutics, 2014-04, Vol.10 (2), p.309-311 |
| issn | 0973-1482 1998-4138 |
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| source | MEDLINE; Medknow Open Access Medical Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Adult Aged Aged, 80 and over Biopsy, Fine-Needle Breast - pathology Breast Neoplasms - pathology Carcinoma, Ductal, Breast - pathology Female Humans Micronuclei, Chromosome-Defective Middle Aged Retrospective Studies Rural Population Young Adult |
| title | Micronuclei in breast aspirates. Is scoring them helpful? |
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