The role of leptin in striped hamsters subjected to food restriction and refeeding
Food restriction (FR) and refeeding (Re) have been suggested to impair body mass regulation and thereby making it easier to regain the lost weight and develop over-weight when FR ends. However, it is unclear if this is the case in small mammals showing seasonal forging behaviors. In the present stud...
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| Veröffentlicht in: | Dōngwùxué yánjiū 2014-07, Vol.35 (4), p.262-271 |
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| creator | ZHAO, Zhi-Jun LIU, Yong-An XING, Jing-Ya ZHANG, Mao-Lun NI, Xiao-Ying CAO, Jing |
| description | Food restriction (FR) and refeeding (Re) have been suggested to impair
body mass regulation and thereby making it easier to regain the lost
weight and develop over-weight when FR ends. However, it is unclear if
this is the case in small mammals showing seasonal forging behaviors.
In the present study, energy budget, body fat and serum leptin level
were measured in striped hamsters that were exposed to FR-Re. The
effects of leptin on food intake, body fat and genes expressions of
several hypothalamus neuropeptides were determined. Body mass, fat
content and serum leptin level decreased during FR and then increased
during Re. Leptin supplement significantly attenuated the increase in
food intake during Re, decreased genes expressions of neuropepetide Y
(NPY) and agouti-related protein (AgRP) of hypothalamus and leptin of
white adipose tissue (WAT). Hormone-sensitive lipase (HSL) gene
expression of WAT increased in leptin-treated hamsters that were fed ad
libitum, but decreased in FR-Re hamsters. This indicates that the
adaptive regulation of WAT HSL gene expression may be involved in the
mobilization of fat storage during Re, which partly contributes to the
resistance to FR-Re-induced overweight. Leptin may be involved in the
down regulations of hypothalamus orexigenic peptides gene expression
and consequently plays a crucial role in controlling food intake when
FR ends. |
| doi_str_mv | 10.13918/j.issn.2095-8137.2014.4.262 |
| format | Article |
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body mass regulation and thereby making it easier to regain the lost
weight and develop over-weight when FR ends. However, it is unclear if
this is the case in small mammals showing seasonal forging behaviors.
In the present study, energy budget, body fat and serum leptin level
were measured in striped hamsters that were exposed to FR-Re. The
effects of leptin on food intake, body fat and genes expressions of
several hypothalamus neuropeptides were determined. Body mass, fat
content and serum leptin level decreased during FR and then increased
during Re. Leptin supplement significantly attenuated the increase in
food intake during Re, decreased genes expressions of neuropepetide Y
(NPY) and agouti-related protein (AgRP) of hypothalamus and leptin of
white adipose tissue (WAT). Hormone-sensitive lipase (HSL) gene
expression of WAT increased in leptin-treated hamsters that were fed ad
libitum, but decreased in FR-Re hamsters. This indicates that the
adaptive regulation of WAT HSL gene expression may be involved in the
mobilization of fat storage during Re, which partly contributes to the
resistance to FR-Re-induced overweight. Leptin may be involved in the
down regulations of hypothalamus orexigenic peptides gene expression
and consequently plays a crucial role in controlling food intake when
FR ends.</description><identifier>ISSN: 2095-8137</identifier><identifier>ISSN: 0254-5853</identifier><identifier>EISSN: 2095-8137</identifier><identifier>DOI: 10.13918/j.issn.2095-8137.2014.4.262</identifier><identifier>PMID: 25017744</identifier><language>eng</language><publisher>China: Kunming Institute of Zoology, Chinese Academy of Sciences</publisher><subject>Animal behavior ; Animals ; Biology ; Body mass ; Cricetinae ; Eating - physiology ; Energy Intake - physiology ; Food ; Food Deprivation - physiology ; Food restriction ; Gene Expression Regulation ; Hypothalamus ; Hypothalamus neuropeptides ; Leptin ; Leptin - metabolism ; Male ; Neuropeptides ; Rodents ; Striped hamster ; Weight Gain ; Weight Loss ; Zoology ; 仓鼠 ; 再投喂 ; 基因表达 ; 小型哺乳动物 ; 条纹 ; 瘦素 ; 脑神经肽 ; 食品</subject><ispartof>Dōngwùxué yánjiū, 2014-07, Vol.35 (4), p.262-271</ispartof><rights>Copyright 2014 - Zoological Research</rights><rights>Copyright Kunming Institute of Zoology, The Chinese Academy of Sciences Jul 2014</rights><rights>2014 Editorial Office of Zoological Research, Kunming Institute of Zoology, Chinese Academy of Sciences</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b334t-ac2b3918cc67821fb6792a4dcf0d61b90568fd14b3bdaa92f9c7439cfa7521883</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/95457X/95457X.jpg</thumbnail><link.rule.ids>314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25017744$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ZHAO, Zhi-Jun</creatorcontrib><creatorcontrib>LIU, Yong-An</creatorcontrib><creatorcontrib>XING, Jing-Ya</creatorcontrib><creatorcontrib>ZHANG, Mao-Lun</creatorcontrib><creatorcontrib>NI, Xiao-Ying</creatorcontrib><creatorcontrib>CAO, Jing</creatorcontrib><title>The role of leptin in striped hamsters subjected to food restriction and refeeding</title><title>Dōngwùxué yánjiū</title><addtitle>Zoological Research</addtitle><description>Food restriction (FR) and refeeding (Re) have been suggested to impair
body mass regulation and thereby making it easier to regain the lost
weight and develop over-weight when FR ends. However, it is unclear if
this is the case in small mammals showing seasonal forging behaviors.
In the present study, energy budget, body fat and serum leptin level
were measured in striped hamsters that were exposed to FR-Re. The
effects of leptin on food intake, body fat and genes expressions of
several hypothalamus neuropeptides were determined. Body mass, fat
content and serum leptin level decreased during FR and then increased
during Re. Leptin supplement significantly attenuated the increase in
food intake during Re, decreased genes expressions of neuropepetide Y
(NPY) and agouti-related protein (AgRP) of hypothalamus and leptin of
white adipose tissue (WAT). Hormone-sensitive lipase (HSL) gene
expression of WAT increased in leptin-treated hamsters that were fed ad
libitum, but decreased in FR-Re hamsters. This indicates that the
adaptive regulation of WAT HSL gene expression may be involved in the
mobilization of fat storage during Re, which partly contributes to the
resistance to FR-Re-induced overweight. Leptin may be involved in the
down regulations of hypothalamus orexigenic peptides gene expression
and consequently plays a crucial role in controlling food intake when
FR ends.</description><subject>Animal behavior</subject><subject>Animals</subject><subject>Biology</subject><subject>Body mass</subject><subject>Cricetinae</subject><subject>Eating - physiology</subject><subject>Energy Intake - physiology</subject><subject>Food</subject><subject>Food Deprivation - physiology</subject><subject>Food restriction</subject><subject>Gene Expression Regulation</subject><subject>Hypothalamus</subject><subject>Hypothalamus neuropeptides</subject><subject>Leptin</subject><subject>Leptin - metabolism</subject><subject>Male</subject><subject>Neuropeptides</subject><subject>Rodents</subject><subject>Striped hamster</subject><subject>Weight Gain</subject><subject>Weight Loss</subject><subject>Zoology</subject><subject>仓鼠</subject><subject>再投喂</subject><subject>基因表达</subject><subject>小型哺乳动物</subject><subject>条纹</subject><subject>瘦素</subject><subject>脑神经肽</subject><subject>食品</subject><issn>2095-8137</issn><issn>0254-5853</issn><issn>2095-8137</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>RBI</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkF9rFDEUxYNYbKn9CiWoD33ZMTf_ZvIiSLEqFITSPg9JJtnNMptsk5mCfnozbLtU4ULuPflxuOci9AlIA0xB93nbhFJiQ4kSqw5YWzvgDW-opG_Q2VF--6o_RRelBENE7QkF-Q6dUkGgbTk_Q3f3G4dzGh1OHo9uP4WIa5Uph70b8EbvyuRywWU2W2enKk0J-5QGnN0C2SmkiHVcZu_cEOL6PTrxeizu4vk9Rw833-6vf6xuf33_ef31dmUY49NKW2qWSNbKtqPgjWwV1XywngwSjCJCdn4AbpgZtFbUK9typqzXraDQdewcfTn47mezc4N1ccp67Pc57HT-3Scd-n9_Ytj06_TUC8JAtrQaXD0b5PQ41zj9LhTrxlFHl-bSg-ACFGFSVvTjf-g2zTnWeJUSAFwBXwwvX290XOXl3BX4cADsJsX1Yz3WkZESpCRELVBzgExIY4juiNgcdP8i_sm1gNco7C_yUqMy</recordid><startdate>201407</startdate><enddate>201407</enddate><creator>ZHAO, Zhi-Jun</creator><creator>LIU, Yong-An</creator><creator>XING, Jing-Ya</creator><creator>ZHANG, Mao-Lun</creator><creator>NI, Xiao-Ying</creator><creator>CAO, Jing</creator><general>Kunming Institute of Zoology, Chinese Academy of Sciences</general><general>Kunming Institute of Zoology, The Chinese Academy of Sciences</general><general>Science Press</general><scope>RBI</scope><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W94</scope><scope>WU4</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BVBZV</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H95</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L.G</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201407</creationdate><title>The role of leptin in striped hamsters subjected to food restriction and refeeding</title><author>ZHAO, Zhi-Jun ; LIU, Yong-An ; XING, Jing-Ya ; ZHANG, Mao-Lun ; NI, Xiao-Ying ; CAO, Jing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b334t-ac2b3918cc67821fb6792a4dcf0d61b90568fd14b3bdaa92f9c7439cfa7521883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animal behavior</topic><topic>Animals</topic><topic>Biology</topic><topic>Body mass</topic><topic>Cricetinae</topic><topic>Eating - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Dōngwùxué yánjiū</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ZHAO, Zhi-Jun</au><au>LIU, Yong-An</au><au>XING, Jing-Ya</au><au>ZHANG, Mao-Lun</au><au>NI, Xiao-Ying</au><au>CAO, Jing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of leptin in striped hamsters subjected to food restriction and refeeding</atitle><jtitle>Dōngwùxué yánjiū</jtitle><addtitle>Zoological Research</addtitle><date>2014-07</date><risdate>2014</risdate><volume>35</volume><issue>4</issue><spage>262</spage><epage>271</epage><pages>262-271</pages><issn>2095-8137</issn><issn>0254-5853</issn><eissn>2095-8137</eissn><abstract>Food restriction (FR) and refeeding (Re) have been suggested to impair
body mass regulation and thereby making it easier to regain the lost
weight and develop over-weight when FR ends. However, it is unclear if
this is the case in small mammals showing seasonal forging behaviors.
In the present study, energy budget, body fat and serum leptin level
were measured in striped hamsters that were exposed to FR-Re. The
effects of leptin on food intake, body fat and genes expressions of
several hypothalamus neuropeptides were determined. Body mass, fat
content and serum leptin level decreased during FR and then increased
during Re. Leptin supplement significantly attenuated the increase in
food intake during Re, decreased genes expressions of neuropepetide Y
(NPY) and agouti-related protein (AgRP) of hypothalamus and leptin of
white adipose tissue (WAT). Hormone-sensitive lipase (HSL) gene
expression of WAT increased in leptin-treated hamsters that were fed ad
libitum, but decreased in FR-Re hamsters. This indicates that the
adaptive regulation of WAT HSL gene expression may be involved in the
mobilization of fat storage during Re, which partly contributes to the
resistance to FR-Re-induced overweight. Leptin may be involved in the
down regulations of hypothalamus orexigenic peptides gene expression
and consequently plays a crucial role in controlling food intake when
FR ends.</abstract><cop>China</cop><pub>Kunming Institute of Zoology, Chinese Academy of Sciences</pub><pmid>25017744</pmid><doi>10.13918/j.issn.2095-8137.2014.4.262</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2095-8137 |
| ispartof | Dōngwùxué yánjiū, 2014-07, Vol.35 (4), p.262-271 |
| issn | 2095-8137 0254-5853 2095-8137 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1545190366 |
| source | MEDLINE; Bioline International; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animal behavior Animals Biology Body mass Cricetinae Eating - physiology Energy Intake - physiology Food Food Deprivation - physiology Food restriction Gene Expression Regulation Hypothalamus Hypothalamus neuropeptides Leptin Leptin - metabolism Male Neuropeptides Rodents Striped hamster Weight Gain Weight Loss Zoology 仓鼠 再投喂 基因表达 小型哺乳动物 条纹 瘦素 脑神经肽 食品 |
| title | The role of leptin in striped hamsters subjected to food restriction and refeeding |
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