Relationship between plasma apelin level and coronary collateral circulation
Abstract Objective Coronary collaterals play a crucial role during an acute ischemic attack. Angiogenesis has an important role in the formation of coronary collateral vessels. Previously, it was shown that apelin is a potential angiogenetic factor. Thus, we aimed to investigate relationship between...
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| Veröffentlicht in: | Atherosclerosis 2014-08, Vol.235 (2), p.289-294 |
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| creator | Akboga, Mehmet Kadri Akyel, Ahmet Sahinarslan, Asife Demirtas, Canan Yilmaz Yayla, Cagri Boyaci, Bulent Yalcin, Ridvan |
| description | Abstract Objective Coronary collaterals play a crucial role during an acute ischemic attack. Angiogenesis has an important role in the formation of coronary collateral vessels. Previously, it was shown that apelin is a potential angiogenetic factor. Thus, we aimed to investigate relationship between plasma apelin levels and coronary collateral circulation in patients with stable coronary artery disease. Methods Among patients who underwent coronary angiography with stable angina pectoris, patients with a stenosis of ≥90% were included in our study. Collateral degree was graded according to Rentrop–Cohen classification. Patients with grade 2 or 3 collateral degree were included in good collateral group and patients with grade 0 or 1 collateral degree were included in poor collateral group. Results Plasma apelin level was significantly higher in good collateral group (0.69 ± 0.2 vs 0.59 ± 0.2 ng/dl, p |
| doi_str_mv | 10.1016/j.atherosclerosis.2014.04.029 |
| format | Article |
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Angiogenesis has an important role in the formation of coronary collateral vessels. Previously, it was shown that apelin is a potential angiogenetic factor. Thus, we aimed to investigate relationship between plasma apelin levels and coronary collateral circulation in patients with stable coronary artery disease. Methods Among patients who underwent coronary angiography with stable angina pectoris, patients with a stenosis of ≥90% were included in our study. Collateral degree was graded according to Rentrop–Cohen classification. Patients with grade 2 or 3 collateral degree were included in good collateral group and patients with grade 0 or 1 collateral degree were included in poor collateral group. Results Plasma apelin level was significantly higher in good collateral group (0.69 ± 0.2 vs 0.59 ± 0.2 ng/dl, p < 0.001). Serum nitric oxide levels were similar between two groups. In multivariate regression analysis apelin [6.95 (1.46–33.15), p = 0.015] and presence of total occlusion [4.40 (1.04–18.62), p = 0.044] remained as independent predictors for good coronary collateral development. Conclusions Higher plasma apelin level was related to better coronary collateral development. Demonstration of favorable affects of apelin on good collateral development may lead to consider apelin in antiischemic treatment strategies in order to increase collateral development.</description><identifier>ISSN: 0021-9150</identifier><identifier>EISSN: 1879-1484</identifier><identifier>DOI: 10.1016/j.atherosclerosis.2014.04.029</identifier><identifier>PMID: 24905139</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Angiogenesis ; Apelin ; Biomarkers - blood ; Cardiovascular ; Collateral circulation ; Collateral Circulation - physiology ; Coronary artery disease ; Coronary Circulation - drug effects ; Humans ; Intercellular Signaling Peptides and Proteins - blood</subject><ispartof>Atherosclerosis, 2014-08, Vol.235 (2), p.289-294</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2014 Elsevier Ireland Ltd</rights><rights>Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c565t-d6a9f94fbb54293049349927c18d8b0f7125aa4fe7910dee98e42e00db714ed83</citedby><cites>FETCH-LOGICAL-c565t-d6a9f94fbb54293049349927c18d8b0f7125aa4fe7910dee98e42e00db714ed83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0021915014002299$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24905139$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Akboga, Mehmet Kadri</creatorcontrib><creatorcontrib>Akyel, Ahmet</creatorcontrib><creatorcontrib>Sahinarslan, Asife</creatorcontrib><creatorcontrib>Demirtas, Canan Yilmaz</creatorcontrib><creatorcontrib>Yayla, Cagri</creatorcontrib><creatorcontrib>Boyaci, Bulent</creatorcontrib><creatorcontrib>Yalcin, Ridvan</creatorcontrib><title>Relationship between plasma apelin level and coronary collateral circulation</title><title>Atherosclerosis</title><addtitle>Atherosclerosis</addtitle><description>Abstract Objective Coronary collaterals play a crucial role during an acute ischemic attack. Angiogenesis has an important role in the formation of coronary collateral vessels. Previously, it was shown that apelin is a potential angiogenetic factor. Thus, we aimed to investigate relationship between plasma apelin levels and coronary collateral circulation in patients with stable coronary artery disease. Methods Among patients who underwent coronary angiography with stable angina pectoris, patients with a stenosis of ≥90% were included in our study. Collateral degree was graded according to Rentrop–Cohen classification. Patients with grade 2 or 3 collateral degree were included in good collateral group and patients with grade 0 or 1 collateral degree were included in poor collateral group. Results Plasma apelin level was significantly higher in good collateral group (0.69 ± 0.2 vs 0.59 ± 0.2 ng/dl, p < 0.001). Serum nitric oxide levels were similar between two groups. In multivariate regression analysis apelin [6.95 (1.46–33.15), p = 0.015] and presence of total occlusion [4.40 (1.04–18.62), p = 0.044] remained as independent predictors for good coronary collateral development. Conclusions Higher plasma apelin level was related to better coronary collateral development. Demonstration of favorable affects of apelin on good collateral development may lead to consider apelin in antiischemic treatment strategies in order to increase collateral development.</description><subject>Angiogenesis</subject><subject>Apelin</subject><subject>Biomarkers - blood</subject><subject>Cardiovascular</subject><subject>Collateral circulation</subject><subject>Collateral Circulation - physiology</subject><subject>Coronary artery disease</subject><subject>Coronary Circulation - drug effects</subject><subject>Humans</subject><subject>Intercellular Signaling Peptides and Proteins - blood</subject><issn>0021-9150</issn><issn>1879-1484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcFq3DAQhkVI6W42fYXgSyEXb2dkeW0dUiihTQoLgSY5C1kas9pobVeyU_L2ldm0h5wCgzSHf_6Z-YaxzwhrBNx82a_1uKPQR-Pn18U1BxRrSMHlCVtiXckcRS1O2RKAYy6xhAU7i3EPAKLC-iNbcCGhxEIu2fYXeT26vos7N2QNjX-IumzwOh50pgfyrss8PZPPdGcz04e-0-ElJT6VUdA-My6Y6ehxzj602kf69Pqv2OOP7w_Xt_n27ubn9bdtbspNOeZ2o2UrRds0peCyACELISWvDNa2bqCtkJdai5YqiWCJZE2CE4BtKhRk62LFLo--Q-h_TxRHdXDRUBqpo36KCktRYi03vErSq6PUJFgxUKuG4A5pBYWgZqBqr94AVTNQBSnScCt28dpqag5k_1f_I5gEN0cBpYWfHQUVjaPOkHWBzKhs797d6usbJ5PoO6P9E71Q3PdT6BJVhSpyBep-vu58XBQp41IWfwEtFKa_</recordid><startdate>20140801</startdate><enddate>20140801</enddate><creator>Akboga, Mehmet Kadri</creator><creator>Akyel, Ahmet</creator><creator>Sahinarslan, Asife</creator><creator>Demirtas, Canan Yilmaz</creator><creator>Yayla, Cagri</creator><creator>Boyaci, Bulent</creator><creator>Yalcin, Ridvan</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140801</creationdate><title>Relationship between plasma apelin level and coronary collateral circulation</title><author>Akboga, Mehmet Kadri ; Akyel, Ahmet ; Sahinarslan, Asife ; Demirtas, Canan Yilmaz ; Yayla, Cagri ; Boyaci, Bulent ; Yalcin, Ridvan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c565t-d6a9f94fbb54293049349927c18d8b0f7125aa4fe7910dee98e42e00db714ed83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Angiogenesis</topic><topic>Apelin</topic><topic>Biomarkers - blood</topic><topic>Cardiovascular</topic><topic>Collateral circulation</topic><topic>Collateral Circulation - physiology</topic><topic>Coronary artery disease</topic><topic>Coronary Circulation - drug effects</topic><topic>Humans</topic><topic>Intercellular Signaling Peptides and Proteins - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akboga, Mehmet Kadri</creatorcontrib><creatorcontrib>Akyel, Ahmet</creatorcontrib><creatorcontrib>Sahinarslan, Asife</creatorcontrib><creatorcontrib>Demirtas, Canan Yilmaz</creatorcontrib><creatorcontrib>Yayla, Cagri</creatorcontrib><creatorcontrib>Boyaci, Bulent</creatorcontrib><creatorcontrib>Yalcin, Ridvan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Atherosclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akboga, Mehmet Kadri</au><au>Akyel, Ahmet</au><au>Sahinarslan, Asife</au><au>Demirtas, Canan Yilmaz</au><au>Yayla, Cagri</au><au>Boyaci, Bulent</au><au>Yalcin, Ridvan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between plasma apelin level and coronary collateral circulation</atitle><jtitle>Atherosclerosis</jtitle><addtitle>Atherosclerosis</addtitle><date>2014-08-01</date><risdate>2014</risdate><volume>235</volume><issue>2</issue><spage>289</spage><epage>294</epage><pages>289-294</pages><issn>0021-9150</issn><eissn>1879-1484</eissn><abstract>Abstract Objective Coronary collaterals play a crucial role during an acute ischemic attack. Angiogenesis has an important role in the formation of coronary collateral vessels. Previously, it was shown that apelin is a potential angiogenetic factor. Thus, we aimed to investigate relationship between plasma apelin levels and coronary collateral circulation in patients with stable coronary artery disease. Methods Among patients who underwent coronary angiography with stable angina pectoris, patients with a stenosis of ≥90% were included in our study. Collateral degree was graded according to Rentrop–Cohen classification. Patients with grade 2 or 3 collateral degree were included in good collateral group and patients with grade 0 or 1 collateral degree were included in poor collateral group. Results Plasma apelin level was significantly higher in good collateral group (0.69 ± 0.2 vs 0.59 ± 0.2 ng/dl, p < 0.001). Serum nitric oxide levels were similar between two groups. In multivariate regression analysis apelin [6.95 (1.46–33.15), p = 0.015] and presence of total occlusion [4.40 (1.04–18.62), p = 0.044] remained as independent predictors for good coronary collateral development. Conclusions Higher plasma apelin level was related to better coronary collateral development. Demonstration of favorable affects of apelin on good collateral development may lead to consider apelin in antiischemic treatment strategies in order to increase collateral development.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>24905139</pmid><doi>10.1016/j.atherosclerosis.2014.04.029</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Angiogenesis Apelin Biomarkers - blood Cardiovascular Collateral circulation Collateral Circulation - physiology Coronary artery disease Coronary Circulation - drug effects Humans Intercellular Signaling Peptides and Proteins - blood |
| title | Relationship between plasma apelin level and coronary collateral circulation |
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