Type 2 diabetes is not associated with an altered plaque phenotype among patients undergoing carotid revascularization. A histological analysis of 1455 carotid plaques
Abstract Aims Diabetes accelerates progression of atherosclerotic disease, but data on associations between diabetes and advanced atherosclerotic plaque composition are scarce. Methods and results We used one of the largest biobanks, the Athero-Express study ( n = 1455) at carotid endarterectomy (CE...
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| Veröffentlicht in: | Atherosclerosis 2014-08, Vol.235 (2), p.418-423 |
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| creator | Scholtes, Vincent P.W Peeters, Wouter van Lammeren, Guus W Howard, Dominic P.J de Vries, Jean-Paul P.M de Borst, Gert Jan Redgrave, Jessica N Kemperman, Hans Schalkwijk, Casper G den Ruijter, Hester M de Kleijn, Dominique P.V Moll, Frans L Rothwell, Peter M Pasterkamp, Gerard |
| description | Abstract Aims Diabetes accelerates progression of atherosclerotic disease, but data on associations between diabetes and advanced atherosclerotic plaque composition are scarce. Methods and results We used one of the largest biobanks, the Athero-Express study ( n = 1455) at carotid endarterectomy (CEA). All plaques were subjected to histological analysis to assess lipid core size, collagen, macrophages, smooth muscle cells, micro-vessel density and calcifications. In addition, within a subset of patients cytokines and chemokines were assessed. The 295 patients (20%) with type-2 diabetes showed a higher proportion of previous cardiovascular interventions and more stringent treatment for hypertension and hypercholesterolaemia compared with patients without type-2 diabetes. Surprisingly, no associations between diabetes and histological plaque characteristics were observed. In addition, no differences were observed in the expression of inflammatory chemokines, cytokines or advanced glycation end products in plaques of diabetic and non-diabetic patients. Conclusion In patients suffering from significant carotid artery disease, diabetes does not appear to be associated with specific atherosclerotic plaque characteristics. |
| doi_str_mv | 10.1016/j.atherosclerosis.2014.05.941 |
| format | Article |
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A histological analysis of 1455 carotid plaques</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Scholtes, Vincent P.W ; Peeters, Wouter ; van Lammeren, Guus W ; Howard, Dominic P.J ; de Vries, Jean-Paul P.M ; de Borst, Gert Jan ; Redgrave, Jessica N ; Kemperman, Hans ; Schalkwijk, Casper G ; den Ruijter, Hester M ; de Kleijn, Dominique P.V ; Moll, Frans L ; Rothwell, Peter M ; Pasterkamp, Gerard</creator><creatorcontrib>Scholtes, Vincent P.W ; Peeters, Wouter ; van Lammeren, Guus W ; Howard, Dominic P.J ; de Vries, Jean-Paul P.M ; de Borst, Gert Jan ; Redgrave, Jessica N ; Kemperman, Hans ; Schalkwijk, Casper G ; den Ruijter, Hester M ; de Kleijn, Dominique P.V ; Moll, Frans L ; Rothwell, Peter M ; Pasterkamp, Gerard</creatorcontrib><description>Abstract Aims Diabetes accelerates progression of atherosclerotic disease, but data on associations between diabetes and advanced atherosclerotic plaque composition are scarce. Methods and results We used one of the largest biobanks, the Athero-Express study ( n = 1455) at carotid endarterectomy (CEA). All plaques were subjected to histological analysis to assess lipid core size, collagen, macrophages, smooth muscle cells, micro-vessel density and calcifications. In addition, within a subset of patients cytokines and chemokines were assessed. The 295 patients (20%) with type-2 diabetes showed a higher proportion of previous cardiovascular interventions and more stringent treatment for hypertension and hypercholesterolaemia compared with patients without type-2 diabetes. Surprisingly, no associations between diabetes and histological plaque characteristics were observed. In addition, no differences were observed in the expression of inflammatory chemokines, cytokines or advanced glycation end products in plaques of diabetic and non-diabetic patients. Conclusion In patients suffering from significant carotid artery disease, diabetes does not appear to be associated with specific atherosclerotic plaque characteristics.</description><identifier>ISSN: 0021-9150</identifier><identifier>EISSN: 1879-1484</identifier><identifier>DOI: 10.1016/j.atherosclerosis.2014.05.941</identifier><identifier>PMID: 24937465</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Cardiovascular ; Carotid endarterectomy ; Carotid plaque ; Diabetes ; Diabetes Mellitus, Type 2 - complications ; Endarterectomy, Carotid ; Histology ; Plaque, Atherosclerotic - pathology ; Plaque, Atherosclerotic - physiopathology</subject><ispartof>Atherosclerosis, 2014-08, Vol.235 (2), p.418-423</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2014 Elsevier Ireland Ltd</rights><rights>Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-cf8689fcce2d70d0a6cf9ce645282f488db834590c9c65aebdf73dc9184c02ce3</citedby><cites>FETCH-LOGICAL-c444t-cf8689fcce2d70d0a6cf9ce645282f488db834590c9c65aebdf73dc9184c02ce3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.atherosclerosis.2014.05.941$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24937465$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Scholtes, Vincent P.W</creatorcontrib><creatorcontrib>Peeters, Wouter</creatorcontrib><creatorcontrib>van Lammeren, Guus W</creatorcontrib><creatorcontrib>Howard, Dominic P.J</creatorcontrib><creatorcontrib>de Vries, Jean-Paul P.M</creatorcontrib><creatorcontrib>de Borst, Gert Jan</creatorcontrib><creatorcontrib>Redgrave, Jessica N</creatorcontrib><creatorcontrib>Kemperman, Hans</creatorcontrib><creatorcontrib>Schalkwijk, Casper G</creatorcontrib><creatorcontrib>den Ruijter, Hester M</creatorcontrib><creatorcontrib>de Kleijn, Dominique P.V</creatorcontrib><creatorcontrib>Moll, Frans L</creatorcontrib><creatorcontrib>Rothwell, Peter M</creatorcontrib><creatorcontrib>Pasterkamp, Gerard</creatorcontrib><title>Type 2 diabetes is not associated with an altered plaque phenotype among patients undergoing carotid revascularization. A histological analysis of 1455 carotid plaques</title><title>Atherosclerosis</title><addtitle>Atherosclerosis</addtitle><description>Abstract Aims Diabetes accelerates progression of atherosclerotic disease, but data on associations between diabetes and advanced atherosclerotic plaque composition are scarce. Methods and results We used one of the largest biobanks, the Athero-Express study ( n = 1455) at carotid endarterectomy (CEA). All plaques were subjected to histological analysis to assess lipid core size, collagen, macrophages, smooth muscle cells, micro-vessel density and calcifications. In addition, within a subset of patients cytokines and chemokines were assessed. The 295 patients (20%) with type-2 diabetes showed a higher proportion of previous cardiovascular interventions and more stringent treatment for hypertension and hypercholesterolaemia compared with patients without type-2 diabetes. Surprisingly, no associations between diabetes and histological plaque characteristics were observed. In addition, no differences were observed in the expression of inflammatory chemokines, cytokines or advanced glycation end products in plaques of diabetic and non-diabetic patients. Conclusion In patients suffering from significant carotid artery disease, diabetes does not appear to be associated with specific atherosclerotic plaque characteristics.</description><subject>Cardiovascular</subject><subject>Carotid endarterectomy</subject><subject>Carotid plaque</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Endarterectomy, Carotid</subject><subject>Histology</subject><subject>Plaque, Atherosclerotic - pathology</subject><subject>Plaque, Atherosclerotic - physiopathology</subject><issn>0021-9150</issn><issn>1879-1484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUsFu1DAQtRCILoVfQL4gcUlqZ-3EOYBUVVCQKnGgnC3veLLrxRsH2ylafqi_iaMtPfTExfZY783TvDeEvOOs5oy3F_va5B3GkMAvp0t1w7iomax7wZ-RFVddX3GhxHOyYqzhVc8lOyOvUtozxkTH1Uty1oh-3YlWrsj97XFC2lDrzAYzJuoSHUOmJqUAzmS09LfLO2pGanzGWOrJm18z0mmHBbiwzSGMWzqZ7HDMic6jxbgNrvyBiSE7SyPemQSzN9H9KbAw1vSS7lzKwYetA-NLf-OPZRoaBsqFlI_Uk1p6TV4Mxid883Cfkx-fP91efaluvl1_vbq8qUAIkSsYVKv6AQAb2zHLTAtDD9gK2ahmEErZjVoL2TPooZUGN3bo1hZ6rgSwBnB9Tt6f-k4xLLpZH1wC9N6MGOakuRSSq-IeL9APJyiUHFLEQU_RHUw8as70kpXe6ydZ6SUrzaQuWRX-2wepeXNA-8j-F04BXJ8AWAa-cxh1gmIxoHURIWsb3H9LfXzSCbwbF-N_4hHTPsyx-F-m06nRTH9fFmfZGy4YXx7rvzOfyOk</recordid><startdate>20140801</startdate><enddate>20140801</enddate><creator>Scholtes, Vincent P.W</creator><creator>Peeters, Wouter</creator><creator>van Lammeren, Guus W</creator><creator>Howard, Dominic P.J</creator><creator>de Vries, Jean-Paul P.M</creator><creator>de Borst, Gert Jan</creator><creator>Redgrave, Jessica N</creator><creator>Kemperman, Hans</creator><creator>Schalkwijk, Casper G</creator><creator>den Ruijter, Hester M</creator><creator>de Kleijn, Dominique P.V</creator><creator>Moll, Frans L</creator><creator>Rothwell, Peter M</creator><creator>Pasterkamp, Gerard</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140801</creationdate><title>Type 2 diabetes is not associated with an altered plaque phenotype among patients undergoing carotid revascularization. A histological analysis of 1455 carotid plaques</title><author>Scholtes, Vincent P.W ; Peeters, Wouter ; van Lammeren, Guus W ; Howard, Dominic P.J ; de Vries, Jean-Paul P.M ; de Borst, Gert Jan ; Redgrave, Jessica N ; Kemperman, Hans ; Schalkwijk, Casper G ; den Ruijter, Hester M ; de Kleijn, Dominique P.V ; Moll, Frans L ; Rothwell, Peter M ; Pasterkamp, Gerard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-cf8689fcce2d70d0a6cf9ce645282f488db834590c9c65aebdf73dc9184c02ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Cardiovascular</topic><topic>Carotid endarterectomy</topic><topic>Carotid plaque</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Endarterectomy, Carotid</topic><topic>Histology</topic><topic>Plaque, Atherosclerotic - pathology</topic><topic>Plaque, Atherosclerotic - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Scholtes, Vincent P.W</creatorcontrib><creatorcontrib>Peeters, Wouter</creatorcontrib><creatorcontrib>van Lammeren, Guus W</creatorcontrib><creatorcontrib>Howard, Dominic P.J</creatorcontrib><creatorcontrib>de Vries, Jean-Paul P.M</creatorcontrib><creatorcontrib>de Borst, Gert Jan</creatorcontrib><creatorcontrib>Redgrave, Jessica N</creatorcontrib><creatorcontrib>Kemperman, Hans</creatorcontrib><creatorcontrib>Schalkwijk, Casper G</creatorcontrib><creatorcontrib>den Ruijter, Hester M</creatorcontrib><creatorcontrib>de Kleijn, Dominique P.V</creatorcontrib><creatorcontrib>Moll, Frans L</creatorcontrib><creatorcontrib>Rothwell, Peter M</creatorcontrib><creatorcontrib>Pasterkamp, Gerard</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Atherosclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Scholtes, Vincent P.W</au><au>Peeters, Wouter</au><au>van Lammeren, Guus W</au><au>Howard, Dominic P.J</au><au>de Vries, Jean-Paul P.M</au><au>de Borst, Gert Jan</au><au>Redgrave, Jessica N</au><au>Kemperman, Hans</au><au>Schalkwijk, Casper G</au><au>den Ruijter, Hester M</au><au>de Kleijn, Dominique P.V</au><au>Moll, Frans L</au><au>Rothwell, Peter M</au><au>Pasterkamp, Gerard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Type 2 diabetes is not associated with an altered plaque phenotype among patients undergoing carotid revascularization. A histological analysis of 1455 carotid plaques</atitle><jtitle>Atherosclerosis</jtitle><addtitle>Atherosclerosis</addtitle><date>2014-08-01</date><risdate>2014</risdate><volume>235</volume><issue>2</issue><spage>418</spage><epage>423</epage><pages>418-423</pages><issn>0021-9150</issn><eissn>1879-1484</eissn><abstract>Abstract Aims Diabetes accelerates progression of atherosclerotic disease, but data on associations between diabetes and advanced atherosclerotic plaque composition are scarce. Methods and results We used one of the largest biobanks, the Athero-Express study ( n = 1455) at carotid endarterectomy (CEA). All plaques were subjected to histological analysis to assess lipid core size, collagen, macrophages, smooth muscle cells, micro-vessel density and calcifications. In addition, within a subset of patients cytokines and chemokines were assessed. The 295 patients (20%) with type-2 diabetes showed a higher proportion of previous cardiovascular interventions and more stringent treatment for hypertension and hypercholesterolaemia compared with patients without type-2 diabetes. Surprisingly, no associations between diabetes and histological plaque characteristics were observed. In addition, no differences were observed in the expression of inflammatory chemokines, cytokines or advanced glycation end products in plaques of diabetic and non-diabetic patients. Conclusion In patients suffering from significant carotid artery disease, diabetes does not appear to be associated with specific atherosclerotic plaque characteristics.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>24937465</pmid><doi>10.1016/j.atherosclerosis.2014.05.941</doi><tpages>6</tpages></addata></record> |
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| subjects | Cardiovascular Carotid endarterectomy Carotid plaque Diabetes Diabetes Mellitus, Type 2 - complications Endarterectomy, Carotid Histology Plaque, Atherosclerotic - pathology Plaque, Atherosclerotic - physiopathology |
| title | Type 2 diabetes is not associated with an altered plaque phenotype among patients undergoing carotid revascularization. A histological analysis of 1455 carotid plaques |
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