In-depth investigation for prescribing trends of benzodiazepines in South Korea
This study aimed to investigate national prescription trends of benzodiazepines (BZD) for adults between 2007 and 2011 using Health Insurance Review and Assessment Service (HIRA) database in South Korea. Data analysis was performed by claim unit or patient unit. For the analysis of patient unit, eac...
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Veröffentlicht in: | International journal of clinical pharmacology and therapeutics 2014-06, Vol.52 (6), p.460-470 |
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container_title | International journal of clinical pharmacology and therapeutics |
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creator | OH, Sung-Hee KANG SEOB OH LEE, Kyoung-Uk WOO, Jong-Min LEE, Boung-Chul JIN SEUB HWANG EUNJEONG PARK SU JIN KWAK KWON, Jin-Won |
description | This study aimed to investigate national prescription trends of benzodiazepines (BZD) for adults between 2007 and 2011 using Health Insurance Review and Assessment Service (HIRA) database in South Korea. Data analysis was performed by claim unit or patient unit. For the analysis of patient unit, each claim was merged by the same patient. Defined daily dose (DDD) was used to analyze the data in terms of dose and periods of BZD prescription. We identified a total of 22,361,449 adult patients who had BZD prescription at least once in 1,989,263 claims during 5 years. The average national BZD prescription prevalence for 1 year was 23.7%, 7.9%, 4.7%, and 3.2% of >= 1 day supply, >= 30 days supply, >= 90 days supply, and >= 180 days supply, respectively. The trends for 5 years were very similar. Among study population, 87.7% visited only non-psychiatric departments and the most frequent indication was gastrointestinal related diseases. BZD consumption expressed as DDDs per 1,000 inhabitants per day was 109.2. BZD consumption tended to be ~ 4 x higher in elderly than that of non-elderly (268.6 vs. 60.0 in male and 367.7 vs. 90.9 in female). Our study indicated the possibilities for inappropriate prescription of BZD, and the limitation policy on continuous prescription over 30 days supply did not seem to be effective. The effective interventions including an educational program for appropriate prescription of BZD should be considered. |
doi_str_mv | 10.5414/CP202008 |
format | Article |
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Data analysis was performed by claim unit or patient unit. For the analysis of patient unit, each claim was merged by the same patient. Defined daily dose (DDD) was used to analyze the data in terms of dose and periods of BZD prescription. We identified a total of 22,361,449 adult patients who had BZD prescription at least once in 1,989,263 claims during 5 years. The average national BZD prescription prevalence for 1 year was 23.7%, 7.9%, 4.7%, and 3.2% of >= 1 day supply, >= 30 days supply, >= 90 days supply, and >= 180 days supply, respectively. The trends for 5 years were very similar. Among study population, 87.7% visited only non-psychiatric departments and the most frequent indication was gastrointestinal related diseases. BZD consumption expressed as DDDs per 1,000 inhabitants per day was 109.2. BZD consumption tended to be ~ 4 x higher in elderly than that of non-elderly (268.6 vs. 60.0 in male and 367.7 vs. 90.9 in female). Our study indicated the possibilities for inappropriate prescription of BZD, and the limitation policy on continuous prescription over 30 days supply did not seem to be effective. The effective interventions including an educational program for appropriate prescription of BZD should be considered.</description><identifier>ISSN: 0946-1965</identifier><identifier>DOI: 10.5414/CP202008</identifier><identifier>PMID: 24786014</identifier><language>eng</language><publisher>München: Dustri</publisher><subject>Age Distribution ; Age Factors ; Benzodiazepines - adverse effects ; Benzodiazepines - therapeutic use ; Biological and medical sciences ; Central Nervous System Agents - adverse effects ; Central Nervous System Agents - therapeutic use ; Drug Prescriptions ; Drug Utilization Review - trends ; Female ; Gastrointestinal Agents - adverse effects ; Gastrointestinal Agents - therapeutic use ; Humans ; Inappropriate Prescribing - trends ; Insurance, Pharmaceutical Services - trends ; Male ; Medical sciences ; Patient Safety ; Pharmacology. Drug treatments ; Practice Patterns, Physicians' - trends ; Republic of Korea ; Sex Distribution ; Sex Factors ; Time Factors</subject><ispartof>International journal of clinical pharmacology and therapeutics, 2014-06, Vol.52 (6), p.460-470</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c313t-7b13e8c0207bbdb61f55017bf7bddf77143e293320c6fa9d6a14d04cb35baa5c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28494894$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24786014$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>OH, Sung-Hee</creatorcontrib><creatorcontrib>KANG SEOB OH</creatorcontrib><creatorcontrib>LEE, Kyoung-Uk</creatorcontrib><creatorcontrib>WOO, Jong-Min</creatorcontrib><creatorcontrib>LEE, Boung-Chul</creatorcontrib><creatorcontrib>JIN SEUB HWANG</creatorcontrib><creatorcontrib>EUNJEONG PARK</creatorcontrib><creatorcontrib>SU JIN KWAK</creatorcontrib><creatorcontrib>KWON, Jin-Won</creatorcontrib><title>In-depth investigation for prescribing trends of benzodiazepines in South Korea</title><title>International journal of clinical pharmacology and therapeutics</title><addtitle>Int J Clin Pharmacol Ther</addtitle><description>This study aimed to investigate national prescription trends of benzodiazepines (BZD) for adults between 2007 and 2011 using Health Insurance Review and Assessment Service (HIRA) database in South Korea. Data analysis was performed by claim unit or patient unit. For the analysis of patient unit, each claim was merged by the same patient. Defined daily dose (DDD) was used to analyze the data in terms of dose and periods of BZD prescription. We identified a total of 22,361,449 adult patients who had BZD prescription at least once in 1,989,263 claims during 5 years. The average national BZD prescription prevalence for 1 year was 23.7%, 7.9%, 4.7%, and 3.2% of >= 1 day supply, >= 30 days supply, >= 90 days supply, and >= 180 days supply, respectively. The trends for 5 years were very similar. Among study population, 87.7% visited only non-psychiatric departments and the most frequent indication was gastrointestinal related diseases. BZD consumption expressed as DDDs per 1,000 inhabitants per day was 109.2. BZD consumption tended to be ~ 4 x higher in elderly than that of non-elderly (268.6 vs. 60.0 in male and 367.7 vs. 90.9 in female). Our study indicated the possibilities for inappropriate prescription of BZD, and the limitation policy on continuous prescription over 30 days supply did not seem to be effective. The effective interventions including an educational program for appropriate prescription of BZD should be considered.</description><subject>Age Distribution</subject><subject>Age Factors</subject><subject>Benzodiazepines - adverse effects</subject><subject>Benzodiazepines - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Central Nervous System Agents - adverse effects</subject><subject>Central Nervous System Agents - therapeutic use</subject><subject>Drug Prescriptions</subject><subject>Drug Utilization Review - trends</subject><subject>Female</subject><subject>Gastrointestinal Agents - adverse effects</subject><subject>Gastrointestinal Agents - therapeutic use</subject><subject>Humans</subject><subject>Inappropriate Prescribing - trends</subject><subject>Insurance, Pharmaceutical Services - trends</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Patient Safety</subject><subject>Pharmacology. Drug treatments</subject><subject>Practice Patterns, Physicians' - trends</subject><subject>Republic of Korea</subject><subject>Sex Distribution</subject><subject>Sex Factors</subject><subject>Time Factors</subject><issn>0946-1965</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM1LwzAYh3NQ3JyCf4H0InipJk3StEcZfgwHE9RzycebGemSmrSC--utuOnpvTzvw48HoTOCrzgj7Hr-VOAC4-oATXHNypzUJZ-g45TeMS44F_URmhRMVCUmbIpWC58b6Pq3zPlPSL1by94Fn9kQsy5C0tEp59dZH8GblAWbKfDbYJzcQuc8pPEvew7DKHgMEeQJOrSyTXC6uzP0enf7Mn_Il6v7xfxmmWtKaJ8LRShUehwqlDKqJJZzTISyQhljhSCMQlFTWmBdWlmbUhJmMNOKciUl13SGLn-9XQwfwzi82bikoW2lhzCkhnDGSVVxVv6jOoaUItimi24j41dDcPOTrNknG9HznXVQGzB_4L7XCFzsAJm0bG2UXrv0z1WsZlXN6DehBXVh</recordid><startdate>20140601</startdate><enddate>20140601</enddate><creator>OH, Sung-Hee</creator><creator>KANG SEOB OH</creator><creator>LEE, Kyoung-Uk</creator><creator>WOO, Jong-Min</creator><creator>LEE, Boung-Chul</creator><creator>JIN SEUB HWANG</creator><creator>EUNJEONG PARK</creator><creator>SU JIN KWAK</creator><creator>KWON, Jin-Won</creator><general>Dustri</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140601</creationdate><title>In-depth investigation for prescribing trends of benzodiazepines in South Korea</title><author>OH, Sung-Hee ; KANG SEOB OH ; LEE, Kyoung-Uk ; WOO, Jong-Min ; LEE, Boung-Chul ; JIN SEUB HWANG ; EUNJEONG PARK ; SU JIN KWAK ; KWON, Jin-Won</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c313t-7b13e8c0207bbdb61f55017bf7bddf77143e293320c6fa9d6a14d04cb35baa5c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Age Distribution</topic><topic>Age Factors</topic><topic>Benzodiazepines - adverse effects</topic><topic>Benzodiazepines - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Central Nervous System Agents - adverse effects</topic><topic>Central Nervous System Agents - therapeutic use</topic><topic>Drug Prescriptions</topic><topic>Drug Utilization Review - trends</topic><topic>Female</topic><topic>Gastrointestinal Agents - adverse effects</topic><topic>Gastrointestinal Agents - therapeutic use</topic><topic>Humans</topic><topic>Inappropriate Prescribing - trends</topic><topic>Insurance, Pharmaceutical Services - trends</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Patient Safety</topic><topic>Pharmacology. Drug treatments</topic><topic>Practice Patterns, Physicians' - trends</topic><topic>Republic of Korea</topic><topic>Sex Distribution</topic><topic>Sex Factors</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>OH, Sung-Hee</creatorcontrib><creatorcontrib>KANG SEOB OH</creatorcontrib><creatorcontrib>LEE, Kyoung-Uk</creatorcontrib><creatorcontrib>WOO, Jong-Min</creatorcontrib><creatorcontrib>LEE, Boung-Chul</creatorcontrib><creatorcontrib>JIN SEUB HWANG</creatorcontrib><creatorcontrib>EUNJEONG PARK</creatorcontrib><creatorcontrib>SU JIN KWAK</creatorcontrib><creatorcontrib>KWON, Jin-Won</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of clinical pharmacology and therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>OH, Sung-Hee</au><au>KANG SEOB OH</au><au>LEE, Kyoung-Uk</au><au>WOO, Jong-Min</au><au>LEE, Boung-Chul</au><au>JIN SEUB HWANG</au><au>EUNJEONG PARK</au><au>SU JIN KWAK</au><au>KWON, Jin-Won</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In-depth investigation for prescribing trends of benzodiazepines in South Korea</atitle><jtitle>International journal of clinical pharmacology and therapeutics</jtitle><addtitle>Int J Clin Pharmacol Ther</addtitle><date>2014-06-01</date><risdate>2014</risdate><volume>52</volume><issue>6</issue><spage>460</spage><epage>470</epage><pages>460-470</pages><issn>0946-1965</issn><abstract>This study aimed to investigate national prescription trends of benzodiazepines (BZD) for adults between 2007 and 2011 using Health Insurance Review and Assessment Service (HIRA) database in South Korea. Data analysis was performed by claim unit or patient unit. For the analysis of patient unit, each claim was merged by the same patient. Defined daily dose (DDD) was used to analyze the data in terms of dose and periods of BZD prescription. We identified a total of 22,361,449 adult patients who had BZD prescription at least once in 1,989,263 claims during 5 years. The average national BZD prescription prevalence for 1 year was 23.7%, 7.9%, 4.7%, and 3.2% of >= 1 day supply, >= 30 days supply, >= 90 days supply, and >= 180 days supply, respectively. The trends for 5 years were very similar. Among study population, 87.7% visited only non-psychiatric departments and the most frequent indication was gastrointestinal related diseases. BZD consumption expressed as DDDs per 1,000 inhabitants per day was 109.2. BZD consumption tended to be ~ 4 x higher in elderly than that of non-elderly (268.6 vs. 60.0 in male and 367.7 vs. 90.9 in female). Our study indicated the possibilities for inappropriate prescription of BZD, and the limitation policy on continuous prescription over 30 days supply did not seem to be effective. The effective interventions including an educational program for appropriate prescription of BZD should be considered.</abstract><cop>München</cop><pub>Dustri</pub><pmid>24786014</pmid><doi>10.5414/CP202008</doi><tpages>11</tpages></addata></record> |
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subjects | Age Distribution Age Factors Benzodiazepines - adverse effects Benzodiazepines - therapeutic use Biological and medical sciences Central Nervous System Agents - adverse effects Central Nervous System Agents - therapeutic use Drug Prescriptions Drug Utilization Review - trends Female Gastrointestinal Agents - adverse effects Gastrointestinal Agents - therapeutic use Humans Inappropriate Prescribing - trends Insurance, Pharmaceutical Services - trends Male Medical sciences Patient Safety Pharmacology. Drug treatments Practice Patterns, Physicians' - trends Republic of Korea Sex Distribution Sex Factors Time Factors |
title | In-depth investigation for prescribing trends of benzodiazepines in South Korea |
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