Effect of aqueous extract of Dicranopteris linearis leaves against paracetamol and carbon tetrachloride-induced liver toxicity in rats
The present study aimed to determine the hepatoprotective activity of Dicranopteris linearis L. (family Gleicheniaceae) leaf aqueous extract (DLAE) using two models of liver injury in rats. Rats were divided into ten groups (n=6) and received dH2O (negative control), 200 mg/kg silymarin (positive co...
Gespeichert in:
| Veröffentlicht in: | Pakistan journal of pharmaceutical sciences 2014-07, Vol.27 (4), p.831-835 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 835 |
|---|---|
| container_issue | 4 |
| container_start_page | 831 |
| container_title | Pakistan journal of pharmaceutical sciences |
| container_volume | 27 |
| creator | Ismail, Noor Aisyah Shamsahal-Din, Nor Syafawati Mamat, Siti Syariah Zabidi, Zalina Wan Zainulddin, Wan-Noraziemah Kamisan, Farah Hidayah Yahya, Farhana Mohtarrudin, Norhafizah Mohd-Desa, Mohd Nasir Zakaria, Zainul Amiruddin |
| description | The present study aimed to determine the hepatoprotective activity of Dicranopteris linearis L. (family Gleicheniaceae) leaf aqueous extract (DLAE) using two models of liver injury in rats. Rats were divided into ten groups (n=6) and received dH2O (negative control), 200 mg/kg silymarin (positive control) or DLAE (50, 250 and 500 mg/kg) orally once daily for 7 consecutive days and on the 8th day subjected to the hepatotoxic induction either using carbon tetrachloride (CCl4) or paracetamol (PCM). The bloods and livers were collected and subjected to biochemical and microscopical analysis. From the data obtained, only the highest dose of DLAE significantly (P |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1545180269</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A377529584</galeid><sourcerecordid>A377529584</sourcerecordid><originalsourceid>FETCH-LOGICAL-g193t-e3ec53e8813dba7e527bd86e610c53bd7ad3282c0580ced3dad740ea0c022ff53</originalsourceid><addsrcrecordid>eNptkc1KAzEUhWeh2Fp9BQm4cTOSTCbzsyy1_kDBjYK74U5yp0ZmkpqkpX0Bn9vU1oUgd5Fw-HLuPbknyZhRxtKCsrdRcu79B6VFXtf1WTLKBGUiz6tx8jXvOpSB2I7A5xrt2hPcBgcH6U5LB8auAjrtSa8Nws8FYYOewBK08YGsIPIYYLA9AaOIBNdaQwLufd5767TCVBu1lqiiyQYdCXarpQ47og1xEPxFctpB7_HyeE6S1_v5y-wxXTw_PM2mi3TJah5S5CgFx6piXLVQosjKVlUFFoxGvVUlKJ5VmaSiorEZV6DKnCJQSbOs6wSfJDcH35WzMa4PzaC9xL4Hs8_exF8RrKJZUUf0-oAuocdGm87u4-zxZsrLUmS1qPJI3f5DxVI4aGkNdjrqfx5cHSdYtwOqZuX0AG7X_K6EfwMKEokW</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1545180269</pqid></control><display><type>article</type><title>Effect of aqueous extract of Dicranopteris linearis leaves against paracetamol and carbon tetrachloride-induced liver toxicity in rats</title><source>MEDLINE</source><source>Free E-Journal (出版社公開部分のみ）</source><creator>Ismail, Noor Aisyah ; Shamsahal-Din, Nor Syafawati ; Mamat, Siti Syariah ; Zabidi, Zalina ; Wan Zainulddin, Wan-Noraziemah ; Kamisan, Farah Hidayah ; Yahya, Farhana ; Mohtarrudin, Norhafizah ; Mohd-Desa, Mohd Nasir ; Zakaria, Zainul Amiruddin</creator><creatorcontrib>Ismail, Noor Aisyah ; Shamsahal-Din, Nor Syafawati ; Mamat, Siti Syariah ; Zabidi, Zalina ; Wan Zainulddin, Wan-Noraziemah ; Kamisan, Farah Hidayah ; Yahya, Farhana ; Mohtarrudin, Norhafizah ; Mohd-Desa, Mohd Nasir ; Zakaria, Zainul Amiruddin</creatorcontrib><description>The present study aimed to determine the hepatoprotective activity of Dicranopteris linearis L. (family Gleicheniaceae) leaf aqueous extract (DLAE) using two models of liver injury in rats. Rats were divided into ten groups (n=6) and received dH2O (negative control), 200 mg/kg silymarin (positive control) or DLAE (50, 250 and 500 mg/kg) orally once daily for 7 consecutive days and on the 8th day subjected to the hepatotoxic induction either using carbon tetrachloride (CCl4) or paracetamol (PCM). The bloods and livers were collected and subjected to biochemical and microscopical analysis. From the data obtained, only the highest dose of DLAE significantly (P<0.05) reduced the ALP, ALT and AST levels in CCl4-and PCM-induced hepatotoxic rats while the other doses caused significant (P<0.05) reduction only in the levels of ALT and AST. The histological results obtained were in line with the biochemical analysis wherein reduction in the CCl4- and PCM-induced tissue formation of necrosis, steatosis and inflammation occurred in a dose-dependent manner. In conclusion, the DLAE possesses hepatoprotective activity, which could be attributed to its free radicals scavenging and antioxidant activities, and high flavonoids content. Thus, in-depth studies regarding the hepatoprotective activity of DLAE are warranted.</description><identifier>ISSN: 1011-601X</identifier><identifier>PMID: 25015448</identifier><language>eng</language><publisher>Pakistan: Pakistan Journal of Pharmaceutical Sciences</publisher><subject>Acetaminophen ; Acetaminophen - toxicity ; Animals ; Carbon tetrachloride ; Carbon Tetrachloride - toxicity ; Chemical and Drug Induced Liver Injury - pathology ; Chemical and Drug Induced Liver Injury - prevention & control ; Ferns ; Liver - drug effects ; Liver - pathology ; Male ; Medicine, Botanic ; Medicine, Herbal ; Phytotherapy ; Plant Extracts - pharmacology ; Plant Leaves ; Rats ; Rats, Sprague-Dawley</subject><ispartof>Pakistan journal of pharmaceutical sciences, 2014-07, Vol.27 (4), p.831-835</ispartof><rights>COPYRIGHT 2014 Pakistan Journal of Pharmaceutical Sciences</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25015448$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ismail, Noor Aisyah</creatorcontrib><creatorcontrib>Shamsahal-Din, Nor Syafawati</creatorcontrib><creatorcontrib>Mamat, Siti Syariah</creatorcontrib><creatorcontrib>Zabidi, Zalina</creatorcontrib><creatorcontrib>Wan Zainulddin, Wan-Noraziemah</creatorcontrib><creatorcontrib>Kamisan, Farah Hidayah</creatorcontrib><creatorcontrib>Yahya, Farhana</creatorcontrib><creatorcontrib>Mohtarrudin, Norhafizah</creatorcontrib><creatorcontrib>Mohd-Desa, Mohd Nasir</creatorcontrib><creatorcontrib>Zakaria, Zainul Amiruddin</creatorcontrib><title>Effect of aqueous extract of Dicranopteris linearis leaves against paracetamol and carbon tetrachloride-induced liver toxicity in rats</title><title>Pakistan journal of pharmaceutical sciences</title><addtitle>Pak J Pharm Sci</addtitle><description>The present study aimed to determine the hepatoprotective activity of Dicranopteris linearis L. (family Gleicheniaceae) leaf aqueous extract (DLAE) using two models of liver injury in rats. Rats were divided into ten groups (n=6) and received dH2O (negative control), 200 mg/kg silymarin (positive control) or DLAE (50, 250 and 500 mg/kg) orally once daily for 7 consecutive days and on the 8th day subjected to the hepatotoxic induction either using carbon tetrachloride (CCl4) or paracetamol (PCM). The bloods and livers were collected and subjected to biochemical and microscopical analysis. From the data obtained, only the highest dose of DLAE significantly (P<0.05) reduced the ALP, ALT and AST levels in CCl4-and PCM-induced hepatotoxic rats while the other doses caused significant (P<0.05) reduction only in the levels of ALT and AST. The histological results obtained were in line with the biochemical analysis wherein reduction in the CCl4- and PCM-induced tissue formation of necrosis, steatosis and inflammation occurred in a dose-dependent manner. In conclusion, the DLAE possesses hepatoprotective activity, which could be attributed to its free radicals scavenging and antioxidant activities, and high flavonoids content. Thus, in-depth studies regarding the hepatoprotective activity of DLAE are warranted.</description><subject>Acetaminophen</subject><subject>Acetaminophen - toxicity</subject><subject>Animals</subject><subject>Carbon tetrachloride</subject><subject>Carbon Tetrachloride - toxicity</subject><subject>Chemical and Drug Induced Liver Injury - pathology</subject><subject>Chemical and Drug Induced Liver Injury - prevention & control</subject><subject>Ferns</subject><subject>Liver - drug effects</subject><subject>Liver - pathology</subject><subject>Male</subject><subject>Medicine, Botanic</subject><subject>Medicine, Herbal</subject><subject>Phytotherapy</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Leaves</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><issn>1011-601X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkc1KAzEUhWeh2Fp9BQm4cTOSTCbzsyy1_kDBjYK74U5yp0ZmkpqkpX0Bn9vU1oUgd5Fw-HLuPbknyZhRxtKCsrdRcu79B6VFXtf1WTLKBGUiz6tx8jXvOpSB2I7A5xrt2hPcBgcH6U5LB8auAjrtSa8Nws8FYYOewBK08YGsIPIYYLA9AaOIBNdaQwLufd5767TCVBu1lqiiyQYdCXarpQ47og1xEPxFctpB7_HyeE6S1_v5y-wxXTw_PM2mi3TJah5S5CgFx6piXLVQosjKVlUFFoxGvVUlKJ5VmaSiorEZV6DKnCJQSbOs6wSfJDcH35WzMa4PzaC9xL4Hs8_exF8RrKJZUUf0-oAuocdGm87u4-zxZsrLUmS1qPJI3f5DxVI4aGkNdjrqfx5cHSdYtwOqZuX0AG7X_K6EfwMKEokW</recordid><startdate>201407</startdate><enddate>201407</enddate><creator>Ismail, Noor Aisyah</creator><creator>Shamsahal-Din, Nor Syafawati</creator><creator>Mamat, Siti Syariah</creator><creator>Zabidi, Zalina</creator><creator>Wan Zainulddin, Wan-Noraziemah</creator><creator>Kamisan, Farah Hidayah</creator><creator>Yahya, Farhana</creator><creator>Mohtarrudin, Norhafizah</creator><creator>Mohd-Desa, Mohd Nasir</creator><creator>Zakaria, Zainul Amiruddin</creator><general>Pakistan Journal of Pharmaceutical Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201407</creationdate><title>Effect of aqueous extract of Dicranopteris linearis leaves against paracetamol and carbon tetrachloride-induced liver toxicity in rats</title><author>Ismail, Noor Aisyah ; Shamsahal-Din, Nor Syafawati ; Mamat, Siti Syariah ; Zabidi, Zalina ; Wan Zainulddin, Wan-Noraziemah ; Kamisan, Farah Hidayah ; Yahya, Farhana ; Mohtarrudin, Norhafizah ; Mohd-Desa, Mohd Nasir ; Zakaria, Zainul Amiruddin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g193t-e3ec53e8813dba7e527bd86e610c53bd7ad3282c0580ced3dad740ea0c022ff53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Acetaminophen</topic><topic>Acetaminophen - toxicity</topic><topic>Animals</topic><topic>Carbon tetrachloride</topic><topic>Carbon Tetrachloride - toxicity</topic><topic>Chemical and Drug Induced Liver Injury - pathology</topic><topic>Chemical and Drug Induced Liver Injury - prevention & control</topic><topic>Ferns</topic><topic>Liver - drug effects</topic><topic>Liver - pathology</topic><topic>Male</topic><topic>Medicine, Botanic</topic><topic>Medicine, Herbal</topic><topic>Phytotherapy</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Leaves</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ismail, Noor Aisyah</creatorcontrib><creatorcontrib>Shamsahal-Din, Nor Syafawati</creatorcontrib><creatorcontrib>Mamat, Siti Syariah</creatorcontrib><creatorcontrib>Zabidi, Zalina</creatorcontrib><creatorcontrib>Wan Zainulddin, Wan-Noraziemah</creatorcontrib><creatorcontrib>Kamisan, Farah Hidayah</creatorcontrib><creatorcontrib>Yahya, Farhana</creatorcontrib><creatorcontrib>Mohtarrudin, Norhafizah</creatorcontrib><creatorcontrib>Mohd-Desa, Mohd Nasir</creatorcontrib><creatorcontrib>Zakaria, Zainul Amiruddin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Pakistan journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ismail, Noor Aisyah</au><au>Shamsahal-Din, Nor Syafawati</au><au>Mamat, Siti Syariah</au><au>Zabidi, Zalina</au><au>Wan Zainulddin, Wan-Noraziemah</au><au>Kamisan, Farah Hidayah</au><au>Yahya, Farhana</au><au>Mohtarrudin, Norhafizah</au><au>Mohd-Desa, Mohd Nasir</au><au>Zakaria, Zainul Amiruddin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of aqueous extract of Dicranopteris linearis leaves against paracetamol and carbon tetrachloride-induced liver toxicity in rats</atitle><jtitle>Pakistan journal of pharmaceutical sciences</jtitle><addtitle>Pak J Pharm Sci</addtitle><date>2014-07</date><risdate>2014</risdate><volume>27</volume><issue>4</issue><spage>831</spage><epage>835</epage><pages>831-835</pages><issn>1011-601X</issn><abstract>The present study aimed to determine the hepatoprotective activity of Dicranopteris linearis L. (family Gleicheniaceae) leaf aqueous extract (DLAE) using two models of liver injury in rats. Rats were divided into ten groups (n=6) and received dH2O (negative control), 200 mg/kg silymarin (positive control) or DLAE (50, 250 and 500 mg/kg) orally once daily for 7 consecutive days and on the 8th day subjected to the hepatotoxic induction either using carbon tetrachloride (CCl4) or paracetamol (PCM). The bloods and livers were collected and subjected to biochemical and microscopical analysis. From the data obtained, only the highest dose of DLAE significantly (P<0.05) reduced the ALP, ALT and AST levels in CCl4-and PCM-induced hepatotoxic rats while the other doses caused significant (P<0.05) reduction only in the levels of ALT and AST. The histological results obtained were in line with the biochemical analysis wherein reduction in the CCl4- and PCM-induced tissue formation of necrosis, steatosis and inflammation occurred in a dose-dependent manner. In conclusion, the DLAE possesses hepatoprotective activity, which could be attributed to its free radicals scavenging and antioxidant activities, and high flavonoids content. Thus, in-depth studies regarding the hepatoprotective activity of DLAE are warranted.</abstract><cop>Pakistan</cop><pub>Pakistan Journal of Pharmaceutical Sciences</pub><pmid>25015448</pmid><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1011-601X |
| ispartof | Pakistan journal of pharmaceutical sciences, 2014-07, Vol.27 (4), p.831-835 |
| issn | 1011-601X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1545180269 |
| source | MEDLINE; Free E-Journal (出版社公開部分のみ） |
| subjects | Acetaminophen Acetaminophen - toxicity Animals Carbon tetrachloride Carbon Tetrachloride - toxicity Chemical and Drug Induced Liver Injury - pathology Chemical and Drug Induced Liver Injury - prevention & control Ferns Liver - drug effects Liver - pathology Male Medicine, Botanic Medicine, Herbal Phytotherapy Plant Extracts - pharmacology Plant Leaves Rats Rats, Sprague-Dawley |
| title | Effect of aqueous extract of Dicranopteris linearis leaves against paracetamol and carbon tetrachloride-induced liver toxicity in rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T07%3A19%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20aqueous%20extract%20of%20Dicranopteris%20linearis%20leaves%20against%20paracetamol%20and%20carbon%20tetrachloride-induced%20liver%20toxicity%20in%20rats&rft.jtitle=Pakistan%20journal%20of%20pharmaceutical%20sciences&rft.au=Ismail,%20Noor%20Aisyah&rft.date=2014-07&rft.volume=27&rft.issue=4&rft.spage=831&rft.epage=835&rft.pages=831-835&rft.issn=1011-601X&rft_id=info:doi/&rft_dat=%3Cgale_proqu%3EA377529584%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1545180269&rft_id=info:pmid/25015448&rft_galeid=A377529584&rfr_iscdi=true |