The heterogeneity of serologic findings and predisposing host factors in drug‐induced lupus erythematosus
Systemic lupus erythematosus (SLE) is a multifaceted disease in which the etiologic agent is unknown. Various factors associated with its pathogenesis include antinuclear antibodies (ANA) especially antinative DNA (a-nDNA) complement activation, an abnormal immunologic balance with decreased T lymph...
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| Veröffentlicht in: | Arthritis and rheumatism 1981-08, Vol.24 (8), p.1070-1073 |
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| container_title | Arthritis and rheumatism |
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| creator | Hughes, G. R. V. Rynes, R. I. Gharavi, A. Ryan, P. F. J. Sewell, J. Mansilla, R. |
| description | Systemic lupus erythematosus (SLE) is a multifaceted disease in which the etiologic agent is unknown. Various factors associated with its pathogenesis include antinuclear antibodies (ANA) especially antinative DNA (a-nDNA) complement activation, an abnormal immunologic balance with decreased T lymphocyte supressor activity and increased antibody production, and host factors such as gender and histocompatibility antigens. Because drug-induced lupus erythematosus (DLE) is triggered by a known agent, analysis of this type of lupus may lead to a better understanding of the development of SLE. Recent studies from this unit suggest that pathogenetic mechanisms in drug-induced lupus may also differ depending on the causative drug. By analogy, the diversity of clinical, laboratory, and immunologic findings in systemic lupus erythematosus may indicate that different etiologic factors are operative. |
| doi_str_mv | 10.1002/art.1780240814 |
| format | Article |
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R. V. ; Rynes, R. I. ; Gharavi, A. ; Ryan, P. F. J. ; Sewell, J. ; Mansilla, R.</creator><creatorcontrib>Hughes, G. R. V. ; Rynes, R. I. ; Gharavi, A. ; Ryan, P. F. J. ; Sewell, J. ; Mansilla, R.</creatorcontrib><description>Systemic lupus erythematosus (SLE) is a multifaceted disease in which the etiologic agent is unknown. Various factors associated with its pathogenesis include antinuclear antibodies (ANA) especially antinative DNA (a-nDNA) complement activation, an abnormal immunologic balance with decreased T lymphocyte supressor activity and increased antibody production, and host factors such as gender and histocompatibility antigens. Because drug-induced lupus erythematosus (DLE) is triggered by a known agent, analysis of this type of lupus may lead to a better understanding of the development of SLE. Recent studies from this unit suggest that pathogenetic mechanisms in drug-induced lupus may also differ depending on the causative drug. 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Because drug-induced lupus erythematosus (DLE) is triggered by a known agent, analysis of this type of lupus may lead to a better understanding of the development of SLE. Recent studies from this unit suggest that pathogenetic mechanisms in drug-induced lupus may also differ depending on the causative drug. 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| fulltext | fulltext |
| identifier | ISSN: 0004-3591 |
| ispartof | Arthritis and rheumatism, 1981-08, Vol.24 (8), p.1070-1073 |
| issn | 0004-3591 1529-0131 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Acetylation Antibodies, Antinuclear Antilymphocyte Serum Arthritis, Rheumatoid - immunology Complement Fixation Tests Female Histocompatibility Antigens Class II Humans Hydralazine - adverse effects Keratoconjunctivitis - immunology Lupus Erythematosus, Systemic - chemically induced Lupus Erythematosus, Systemic - immunology Male Penicillamine - adverse effects Time Factors |
| title | The heterogeneity of serologic findings and predisposing host factors in drug‐induced lupus erythematosus |
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