Abnormal cervical cytology after allogeneic bone marrow transplantation
Allogeneic bone marrow transplantation (BMT) is a procedure mostly used for high-risk hematologic malignances. In women, follow-up protocols after BMT include gynecologic checkups with Papanicolaou (Pap) smears. We evaluated 117 Pap smears in 54 women who underwent allogeneic BMT and correlated the...
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| Veröffentlicht in: | American journal of clinical pathology 2014-08, Vol.142 (2), p.222-226 |
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| creator | Negri, Giovanni Herz, Martina Deola, Sara Piccin, Andrea Casini, Marco Babich, Bianca Tauber, Martina Messini, Sergio Marucci, Maria Raffaella Vittadello, Fabio |
| description | Allogeneic bone marrow transplantation (BMT) is a procedure mostly used for high-risk hematologic malignances. In women, follow-up protocols after BMT include gynecologic checkups with Papanicolaou (Pap) smears.
We evaluated 117 Pap smears in 54 women who underwent allogeneic BMT and correlated the smear morphology with the BMT-related medical treatment.
Abnormal Pap smears after BMT were found in 13 (24.1%) women. Four (7.4%) women had at least one smear with atypical squamous cells of unknown significance, six (11.1%) had a low-grade squamous intraepithelial lesion, and three (5.6%) had atypical squamous cells/high-grade lesion cannot be excluded (ASC-H). The three patients with ASC-H showed high-grade atypia mimicking cancer but had a negative follow-up. Nine women, including the three with ASC-H, had undergone a conditioning therapy for BMT that included busulfan. No association between other drugs and therapy-related atypia was found.
Pap smears after BMT show a high incidence of dysplastic lesions. Moreover, conditioning including busulfan is often associated with therapy-related cytologic atypia, which may lead to unnecessary colposcopies and biopsies. Knowledge of the patient's history and a careful evaluation of the smears are mandatory in these cases. |
| doi_str_mv | 10.1309/AJCP4SKAUS9TOTJX |
| format | Article |
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We evaluated 117 Pap smears in 54 women who underwent allogeneic BMT and correlated the smear morphology with the BMT-related medical treatment.
Abnormal Pap smears after BMT were found in 13 (24.1%) women. Four (7.4%) women had at least one smear with atypical squamous cells of unknown significance, six (11.1%) had a low-grade squamous intraepithelial lesion, and three (5.6%) had atypical squamous cells/high-grade lesion cannot be excluded (ASC-H). The three patients with ASC-H showed high-grade atypia mimicking cancer but had a negative follow-up. Nine women, including the three with ASC-H, had undergone a conditioning therapy for BMT that included busulfan. No association between other drugs and therapy-related atypia was found.
Pap smears after BMT show a high incidence of dysplastic lesions. Moreover, conditioning including busulfan is often associated with therapy-related cytologic atypia, which may lead to unnecessary colposcopies and biopsies. Knowledge of the patient's history and a careful evaluation of the smears are mandatory in these cases.</description><identifier>ISSN: 0002-9173</identifier><identifier>EISSN: 1943-7722</identifier><identifier>DOI: 10.1309/AJCP4SKAUS9TOTJX</identifier><identifier>PMID: 25015864</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Adult ; Aged ; Bone Marrow Transplantation - methods ; Female ; Humans ; Middle Aged ; Neoplasm Grading ; Papanicolaou Test - methods ; Pregnancy ; Transplantation, Homologous - methods ; Treatment Outcome ; Uterine Cervical Dysplasia - pathology ; Uterine Cervical Dysplasia - therapy ; Uterine Cervical Neoplasms - pathology ; Uterine Cervical Neoplasms - therapy ; Vaginal Smears - methods ; Young Adult</subject><ispartof>American journal of clinical pathology, 2014-08, Vol.142 (2), p.222-226</ispartof><rights>Copyright© by the American Society for Clinical Pathology.</rights><rights>Copyright American Society for Clinical Pathology Aug 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-acb4f8b6c1c040fbf0ae228b3bb7a6d3b03ea9c1605b22b24e4251c144e24b203</citedby><cites>FETCH-LOGICAL-c435t-acb4f8b6c1c040fbf0ae228b3bb7a6d3b03ea9c1605b22b24e4251c144e24b203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25015864$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Negri, Giovanni</creatorcontrib><creatorcontrib>Herz, Martina</creatorcontrib><creatorcontrib>Deola, Sara</creatorcontrib><creatorcontrib>Piccin, Andrea</creatorcontrib><creatorcontrib>Casini, Marco</creatorcontrib><creatorcontrib>Babich, Bianca</creatorcontrib><creatorcontrib>Tauber, Martina</creatorcontrib><creatorcontrib>Messini, Sergio</creatorcontrib><creatorcontrib>Marucci, Maria Raffaella</creatorcontrib><creatorcontrib>Vittadello, Fabio</creatorcontrib><title>Abnormal cervical cytology after allogeneic bone marrow transplantation</title><title>American journal of clinical pathology</title><addtitle>Am J Clin Pathol</addtitle><description>Allogeneic bone marrow transplantation (BMT) is a procedure mostly used for high-risk hematologic malignances. In women, follow-up protocols after BMT include gynecologic checkups with Papanicolaou (Pap) smears.
We evaluated 117 Pap smears in 54 women who underwent allogeneic BMT and correlated the smear morphology with the BMT-related medical treatment.
Abnormal Pap smears after BMT were found in 13 (24.1%) women. Four (7.4%) women had at least one smear with atypical squamous cells of unknown significance, six (11.1%) had a low-grade squamous intraepithelial lesion, and three (5.6%) had atypical squamous cells/high-grade lesion cannot be excluded (ASC-H). The three patients with ASC-H showed high-grade atypia mimicking cancer but had a negative follow-up. Nine women, including the three with ASC-H, had undergone a conditioning therapy for BMT that included busulfan. No association between other drugs and therapy-related atypia was found.
Pap smears after BMT show a high incidence of dysplastic lesions. Moreover, conditioning including busulfan is often associated with therapy-related cytologic atypia, which may lead to unnecessary colposcopies and biopsies. Knowledge of the patient's history and a careful evaluation of the smears are mandatory in these cases.</description><subject>Adult</subject><subject>Aged</subject><subject>Bone Marrow Transplantation - methods</subject><subject>Female</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Neoplasm Grading</subject><subject>Papanicolaou Test - methods</subject><subject>Pregnancy</subject><subject>Transplantation, Homologous - methods</subject><subject>Treatment Outcome</subject><subject>Uterine Cervical Dysplasia - pathology</subject><subject>Uterine Cervical Dysplasia - therapy</subject><subject>Uterine Cervical Neoplasms - pathology</subject><subject>Uterine Cervical Neoplasms - therapy</subject><subject>Vaginal Smears - methods</subject><subject>Young Adult</subject><issn>0002-9173</issn><issn>1943-7722</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkM1LAzEQxYMotlbvnmTBi5fVyST7dVyKVmuhQlvwtiRpVrbsbmqyq_S_N6XVg6eZgd97vHmEXFO4pwyyh3w6fuOL13y1yJbz5fT9hAxpxlmYJIinZAgAGGY0YQNy4dwGgGIK_JwMMAIapTEfkkkuW2MbUQdK269K7ZddZ2rzsQtE2WkbiNofutWVCqRpddAIa8130FnRum0t2k50lWkvyVkpaqevjnNEVk-Py_FzOJtPXsb5LFScRV0olORlKmNFFXAoZQlCI6aSSZmIeM0kMC0yRWOIJKJErjlGVFHONXKJwEbk7uC7teaz164rmsopXfsg2vSuoBHnCcsQUo_e_kM3pretT-epCPdlZImn4EApa5yzuiy2tvI_7goKxb7k4n_JXnJzNO5lo9d_gt9W2Q9D53lO</recordid><startdate>201408</startdate><enddate>201408</enddate><creator>Negri, Giovanni</creator><creator>Herz, Martina</creator><creator>Deola, Sara</creator><creator>Piccin, Andrea</creator><creator>Casini, Marco</creator><creator>Babich, Bianca</creator><creator>Tauber, Martina</creator><creator>Messini, Sergio</creator><creator>Marucci, Maria Raffaella</creator><creator>Vittadello, Fabio</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>201408</creationdate><title>Abnormal cervical cytology after allogeneic bone marrow transplantation</title><author>Negri, Giovanni ; 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In women, follow-up protocols after BMT include gynecologic checkups with Papanicolaou (Pap) smears.
We evaluated 117 Pap smears in 54 women who underwent allogeneic BMT and correlated the smear morphology with the BMT-related medical treatment.
Abnormal Pap smears after BMT were found in 13 (24.1%) women. Four (7.4%) women had at least one smear with atypical squamous cells of unknown significance, six (11.1%) had a low-grade squamous intraepithelial lesion, and three (5.6%) had atypical squamous cells/high-grade lesion cannot be excluded (ASC-H). The three patients with ASC-H showed high-grade atypia mimicking cancer but had a negative follow-up. Nine women, including the three with ASC-H, had undergone a conditioning therapy for BMT that included busulfan. No association between other drugs and therapy-related atypia was found.
Pap smears after BMT show a high incidence of dysplastic lesions. Moreover, conditioning including busulfan is often associated with therapy-related cytologic atypia, which may lead to unnecessary colposcopies and biopsies. Knowledge of the patient's history and a careful evaluation of the smears are mandatory in these cases.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>25015864</pmid><doi>10.1309/AJCP4SKAUS9TOTJX</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Aged Bone Marrow Transplantation - methods Female Humans Middle Aged Neoplasm Grading Papanicolaou Test - methods Pregnancy Transplantation, Homologous - methods Treatment Outcome Uterine Cervical Dysplasia - pathology Uterine Cervical Dysplasia - therapy Uterine Cervical Neoplasms - pathology Uterine Cervical Neoplasms - therapy Vaginal Smears - methods Young Adult |
| title | Abnormal cervical cytology after allogeneic bone marrow transplantation |
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