Gadoxetic acid disodium (Gd-EOB-DTPA)-enhanced magnetic resonance imaging for the detection of hepatocellular carcinoma: A meta-analysis
Purpose To evaluate the diagnostic value of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd‐EOB‐DTPA)‐enhanced magnetic resonance imaging (MRI) for hepatocellular carcinoma (HCC). Materials and Methods A systematic, comprehensive literature search was conducted in PubMed (2004 [Gd‐EO...
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| Veröffentlicht in: | Journal of magnetic resonance imaging 2014-05, Vol.39 (5), p.1079-1087 |
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| creator | Junqiang, Lei Yinzhong, Wang Li, Zhang Shunlin, Guo Xiaohui, Wang Yanan, Zhai Kehu, Yang |
| description | Purpose
To evaluate the diagnostic value of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd‐EOB‐DTPA)‐enhanced magnetic resonance imaging (MRI) for hepatocellular carcinoma (HCC).
Materials and Methods
A systematic, comprehensive literature search was conducted in PubMed (2004 [Gd‐EOB‐DTPA was first approved in Europe in 2004] to April 2013), Embase (2004 to April 2013), Web of Science (2004 to April 2013), and the Cochrane Library (2004 to April 2013). The Quality Assessment of Diagnostic Studies (QUADAS) items was used to evaluate the quality of the included studies. Stata 12.0 was used to analyze the data. Pooled sensitivity (SEN), pooled specificity (SPE), pooled positive likelihood ratio (PLR), pooled negative likelihood ratio (NLR), pooled diagnostic odds ratio (dOR), and summary receiver operating characteristic (SROC) curves were calculated to assess the diagnostic value of the individual diagnostic tests.
Results
A total of 11 articles were included, involving 1578 nodules from four countries. The results of the meta‐analysis showed that the pooled SEN, SPE, and SROC curve values were 0.92 (95% confidence interval [CI]: 0.89‐0.94) 0.95 (95% CI: 0.93‐0.97), and 0.98 (95% CI: 0.95‐0.99), respectively, and subgroup analyses were performed.
Conclusion
Gd‐EOB‐DTPA‐enhanced MRI has value for the detection of HCC; in particular, it has high sensitivity for the detection of lesions larger than 10 mm. J. Magn. Reson. Imaging 2014;39:1079–1087 © 2013 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/jmri.24354 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1544321275</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3270804581</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4624-d556837442701dbed2b2b79a8a84da93f9c7bbc47b556aae7044fe2f6ad37c13</originalsourceid><addsrcrecordid>eNpdkc9u1DAQxiNERUvLhQdAlriUg4v_xgm3pZRtq9KuqpU4WhPb6XpJ4q2diO4b8Ngku6UHTjOa-X2jT_Nl2XtKzigh7PO6jf6MCS7Fq-yISsYwk0X-euyJ5JgWRB1mb1NaE0LKUsg32SGThOQ5U0fZnznY8OR6bxAYb5H1KVg_tOh0bvHF3Vf8bbmYfcKuW0FnnEUtPHQ7OroUummG_Djz3QOqQ0T9yiHremd6HzoUarRyG-iDcU0zNBCRgWh8F1r4gmaodT1g6KDZJp9OsoMamuTePdfjbPn9Ynl-iW_u5lfnsxtsRM4EtlLmBVdCMEWorZxlFatUCQUUwkLJ69KoqjJCVSMI4BQRonaszsFyZSg_zk73ZzcxPA4u9br1abIHnQtD0lQKwRllSo7ox__QdRjiaHeiqKBKKcFH6sMzNVSts3oTx3_Erf734hGge-C3b9z2ZU-JnsLTU3h6F56-_nF_tetGDd5rfOrd04sG4i-dK66k_nk717eLkpcLdq0L_hdPIpuP</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1514177743</pqid></control><display><type>article</type><title>Gadoxetic acid disodium (Gd-EOB-DTPA)-enhanced magnetic resonance imaging for the detection of hepatocellular carcinoma: A meta-analysis</title><source>Wiley Free Content</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Junqiang, Lei ; Yinzhong, Wang ; Li, Zhang ; Shunlin, Guo ; Xiaohui, Wang ; Yanan, Zhai ; Kehu, Yang</creator><creatorcontrib>Junqiang, Lei ; Yinzhong, Wang ; Li, Zhang ; Shunlin, Guo ; Xiaohui, Wang ; Yanan, Zhai ; Kehu, Yang</creatorcontrib><description>Purpose
To evaluate the diagnostic value of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd‐EOB‐DTPA)‐enhanced magnetic resonance imaging (MRI) for hepatocellular carcinoma (HCC).
Materials and Methods
A systematic, comprehensive literature search was conducted in PubMed (2004 [Gd‐EOB‐DTPA was first approved in Europe in 2004] to April 2013), Embase (2004 to April 2013), Web of Science (2004 to April 2013), and the Cochrane Library (2004 to April 2013). The Quality Assessment of Diagnostic Studies (QUADAS) items was used to evaluate the quality of the included studies. Stata 12.0 was used to analyze the data. Pooled sensitivity (SEN), pooled specificity (SPE), pooled positive likelihood ratio (PLR), pooled negative likelihood ratio (NLR), pooled diagnostic odds ratio (dOR), and summary receiver operating characteristic (SROC) curves were calculated to assess the diagnostic value of the individual diagnostic tests.
Results
A total of 11 articles were included, involving 1578 nodules from four countries. The results of the meta‐analysis showed that the pooled SEN, SPE, and SROC curve values were 0.92 (95% confidence interval [CI]: 0.89‐0.94) 0.95 (95% CI: 0.93‐0.97), and 0.98 (95% CI: 0.95‐0.99), respectively, and subgroup analyses were performed.
Conclusion
Gd‐EOB‐DTPA‐enhanced MRI has value for the detection of HCC; in particular, it has high sensitivity for the detection of lesions larger than 10 mm. J. Magn. Reson. Imaging 2014;39:1079–1087 © 2013 Wiley Periodicals, Inc.</description><identifier>ISSN: 1053-1807</identifier><identifier>EISSN: 1522-2586</identifier><identifier>DOI: 10.1002/jmri.24354</identifier><identifier>PMID: 25006627</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Carcinoma, Hepatocellular - epidemiology ; Carcinoma, Hepatocellular - pathology ; Contrast Media ; Female ; Gadolinium DTPA ; gadoxetic acid disodium ; Gd-EOB-DTPA ; HCC ; hepatocellular carcinoma ; Humans ; Internationality ; Liver Neoplasms - epidemiology ; Liver Neoplasms - pathology ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Male ; meta-analysis ; Observer Variation ; Prevalence ; Primovist ; Reproducibility of Results ; Risk Factors ; Sensitivity and Specificity</subject><ispartof>Journal of magnetic resonance imaging, 2014-05, Vol.39 (5), p.1079-1087</ispartof><rights>Copyright © 2013 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4624-d556837442701dbed2b2b79a8a84da93f9c7bbc47b556aae7044fe2f6ad37c13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmri.24354$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmri.24354$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25006627$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Junqiang, Lei</creatorcontrib><creatorcontrib>Yinzhong, Wang</creatorcontrib><creatorcontrib>Li, Zhang</creatorcontrib><creatorcontrib>Shunlin, Guo</creatorcontrib><creatorcontrib>Xiaohui, Wang</creatorcontrib><creatorcontrib>Yanan, Zhai</creatorcontrib><creatorcontrib>Kehu, Yang</creatorcontrib><title>Gadoxetic acid disodium (Gd-EOB-DTPA)-enhanced magnetic resonance imaging for the detection of hepatocellular carcinoma: A meta-analysis</title><title>Journal of magnetic resonance imaging</title><addtitle>J. Magn. Reson. Imaging</addtitle><description>Purpose
To evaluate the diagnostic value of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd‐EOB‐DTPA)‐enhanced magnetic resonance imaging (MRI) for hepatocellular carcinoma (HCC).
Materials and Methods
A systematic, comprehensive literature search was conducted in PubMed (2004 [Gd‐EOB‐DTPA was first approved in Europe in 2004] to April 2013), Embase (2004 to April 2013), Web of Science (2004 to April 2013), and the Cochrane Library (2004 to April 2013). The Quality Assessment of Diagnostic Studies (QUADAS) items was used to evaluate the quality of the included studies. Stata 12.0 was used to analyze the data. Pooled sensitivity (SEN), pooled specificity (SPE), pooled positive likelihood ratio (PLR), pooled negative likelihood ratio (NLR), pooled diagnostic odds ratio (dOR), and summary receiver operating characteristic (SROC) curves were calculated to assess the diagnostic value of the individual diagnostic tests.
Results
A total of 11 articles were included, involving 1578 nodules from four countries. The results of the meta‐analysis showed that the pooled SEN, SPE, and SROC curve values were 0.92 (95% confidence interval [CI]: 0.89‐0.94) 0.95 (95% CI: 0.93‐0.97), and 0.98 (95% CI: 0.95‐0.99), respectively, and subgroup analyses were performed.
Conclusion
Gd‐EOB‐DTPA‐enhanced MRI has value for the detection of HCC; in particular, it has high sensitivity for the detection of lesions larger than 10 mm. J. Magn. Reson. Imaging 2014;39:1079–1087 © 2013 Wiley Periodicals, Inc.</description><subject>Carcinoma, Hepatocellular - epidemiology</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Contrast Media</subject><subject>Female</subject><subject>Gadolinium DTPA</subject><subject>gadoxetic acid disodium</subject><subject>Gd-EOB-DTPA</subject><subject>HCC</subject><subject>hepatocellular carcinoma</subject><subject>Humans</subject><subject>Internationality</subject><subject>Liver Neoplasms - epidemiology</subject><subject>Liver Neoplasms - pathology</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>meta-analysis</subject><subject>Observer Variation</subject><subject>Prevalence</subject><subject>Primovist</subject><subject>Reproducibility of Results</subject><subject>Risk Factors</subject><subject>Sensitivity and Specificity</subject><issn>1053-1807</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc9u1DAQxiNERUvLhQdAlriUg4v_xgm3pZRtq9KuqpU4WhPb6XpJ4q2diO4b8Ngku6UHTjOa-X2jT_Nl2XtKzigh7PO6jf6MCS7Fq-yISsYwk0X-euyJ5JgWRB1mb1NaE0LKUsg32SGThOQ5U0fZnznY8OR6bxAYb5H1KVg_tOh0bvHF3Vf8bbmYfcKuW0FnnEUtPHQ7OroUummG_Djz3QOqQ0T9yiHremd6HzoUarRyG-iDcU0zNBCRgWh8F1r4gmaodT1g6KDZJp9OsoMamuTePdfjbPn9Ynl-iW_u5lfnsxtsRM4EtlLmBVdCMEWorZxlFatUCQUUwkLJ69KoqjJCVSMI4BQRonaszsFyZSg_zk73ZzcxPA4u9br1abIHnQtD0lQKwRllSo7ox__QdRjiaHeiqKBKKcFH6sMzNVSts3oTx3_Erf734hGge-C3b9z2ZU-JnsLTU3h6F56-_nF_tetGDd5rfOrd04sG4i-dK66k_nk717eLkpcLdq0L_hdPIpuP</recordid><startdate>201405</startdate><enddate>201405</enddate><creator>Junqiang, Lei</creator><creator>Yinzhong, Wang</creator><creator>Li, Zhang</creator><creator>Shunlin, Guo</creator><creator>Xiaohui, Wang</creator><creator>Yanan, Zhai</creator><creator>Kehu, Yang</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201405</creationdate><title>Gadoxetic acid disodium (Gd-EOB-DTPA)-enhanced magnetic resonance imaging for the detection of hepatocellular carcinoma: A meta-analysis</title><author>Junqiang, Lei ; Yinzhong, Wang ; Li, Zhang ; Shunlin, Guo ; Xiaohui, Wang ; Yanan, Zhai ; Kehu, Yang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4624-d556837442701dbed2b2b79a8a84da93f9c7bbc47b556aae7044fe2f6ad37c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Carcinoma, Hepatocellular - epidemiology</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Contrast Media</topic><topic>Female</topic><topic>Gadolinium DTPA</topic><topic>gadoxetic acid disodium</topic><topic>Gd-EOB-DTPA</topic><topic>HCC</topic><topic>hepatocellular carcinoma</topic><topic>Humans</topic><topic>Internationality</topic><topic>Liver Neoplasms - epidemiology</topic><topic>Liver Neoplasms - pathology</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>meta-analysis</topic><topic>Observer Variation</topic><topic>Prevalence</topic><topic>Primovist</topic><topic>Reproducibility of Results</topic><topic>Risk Factors</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Junqiang, Lei</creatorcontrib><creatorcontrib>Yinzhong, Wang</creatorcontrib><creatorcontrib>Li, Zhang</creatorcontrib><creatorcontrib>Shunlin, Guo</creatorcontrib><creatorcontrib>Xiaohui, Wang</creatorcontrib><creatorcontrib>Yanan, Zhai</creatorcontrib><creatorcontrib>Kehu, Yang</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Junqiang, Lei</au><au>Yinzhong, Wang</au><au>Li, Zhang</au><au>Shunlin, Guo</au><au>Xiaohui, Wang</au><au>Yanan, Zhai</au><au>Kehu, Yang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gadoxetic acid disodium (Gd-EOB-DTPA)-enhanced magnetic resonance imaging for the detection of hepatocellular carcinoma: A meta-analysis</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><addtitle>J. Magn. Reson. Imaging</addtitle><date>2014-05</date><risdate>2014</risdate><volume>39</volume><issue>5</issue><spage>1079</spage><epage>1087</epage><pages>1079-1087</pages><issn>1053-1807</issn><eissn>1522-2586</eissn><abstract>Purpose
To evaluate the diagnostic value of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd‐EOB‐DTPA)‐enhanced magnetic resonance imaging (MRI) for hepatocellular carcinoma (HCC).
Materials and Methods
A systematic, comprehensive literature search was conducted in PubMed (2004 [Gd‐EOB‐DTPA was first approved in Europe in 2004] to April 2013), Embase (2004 to April 2013), Web of Science (2004 to April 2013), and the Cochrane Library (2004 to April 2013). The Quality Assessment of Diagnostic Studies (QUADAS) items was used to evaluate the quality of the included studies. Stata 12.0 was used to analyze the data. Pooled sensitivity (SEN), pooled specificity (SPE), pooled positive likelihood ratio (PLR), pooled negative likelihood ratio (NLR), pooled diagnostic odds ratio (dOR), and summary receiver operating characteristic (SROC) curves were calculated to assess the diagnostic value of the individual diagnostic tests.
Results
A total of 11 articles were included, involving 1578 nodules from four countries. The results of the meta‐analysis showed that the pooled SEN, SPE, and SROC curve values were 0.92 (95% confidence interval [CI]: 0.89‐0.94) 0.95 (95% CI: 0.93‐0.97), and 0.98 (95% CI: 0.95‐0.99), respectively, and subgroup analyses were performed.
Conclusion
Gd‐EOB‐DTPA‐enhanced MRI has value for the detection of HCC; in particular, it has high sensitivity for the detection of lesions larger than 10 mm. J. Magn. Reson. Imaging 2014;39:1079–1087 © 2013 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>25006627</pmid><doi>10.1002/jmri.24354</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of magnetic resonance imaging, 2014-05, Vol.39 (5), p.1079-1087 |
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| subjects | Carcinoma, Hepatocellular - epidemiology Carcinoma, Hepatocellular - pathology Contrast Media Female Gadolinium DTPA gadoxetic acid disodium Gd-EOB-DTPA HCC hepatocellular carcinoma Humans Internationality Liver Neoplasms - epidemiology Liver Neoplasms - pathology Magnetic resonance imaging Magnetic Resonance Imaging - methods Male meta-analysis Observer Variation Prevalence Primovist Reproducibility of Results Risk Factors Sensitivity and Specificity |
| title | Gadoxetic acid disodium (Gd-EOB-DTPA)-enhanced magnetic resonance imaging for the detection of hepatocellular carcinoma: A meta-analysis |
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