A Single-Step Extraction for Screening Whole Blood for Basic Drugs by Capillary GC/NPD
Basic drugs were routinely extracted from whole blood under alkaline conditions into n-butyl acetate. An aliquot of the n-butyl acetate was injected into a gas chromatograph equipped with a nitrogen-phosphorous detector and a wide-bore cross-linked 50% phenylmethyl silicone capillary column. Absolut...
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| Veröffentlicht in: | Journal of analytical toxicology 1989-07, Vol.13 (4), p.224-228 |
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| container_end_page | 228 |
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| container_issue | 4 |
| container_start_page | 224 |
| container_title | Journal of analytical toxicology |
| container_volume | 13 |
| creator | Cox, Robert A. Crifasi, Joseph A. Dickey, Ralph E. Ketzler, Steven C. Pshak, Gary L. |
| description | Basic drugs were routinely extracted from whole blood under alkaline conditions into n-butyl acetate. An aliquot of the n-butyl acetate was injected into a gas chromatograph equipped with a nitrogen-phosphorous detector and a wide-bore cross-linked 50% phenylmethyl silicone capillary column. Absolute and relative retention times were recorded for more than 100 extracted drug standards. Recovery from whole blood was determined for some of the more frequently encountered drugs. This one-step extraction proved to be reliable for general screening and has been used routinely in forensic and clinical toxicological analyses. |
| doi_str_mv | 10.1093/jat/13.4.224 |
| format | Article |
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An aliquot of the n-butyl acetate was injected into a gas chromatograph equipped with a nitrogen-phosphorous detector and a wide-bore cross-linked 50% phenylmethyl silicone capillary column. Absolute and relative retention times were recorded for more than 100 extracted drug standards. Recovery from whole blood was determined for some of the more frequently encountered drugs. This one-step extraction proved to be reliable for general screening and has been used routinely in forensic and clinical toxicological analyses.</description><identifier>ISSN: 0146-4760</identifier><identifier>EISSN: 1945-2403</identifier><identifier>DOI: 10.1093/jat/13.4.224</identifier><identifier>PMID: 2779174</identifier><identifier>CODEN: JATOD3</identifier><language>eng</language><publisher>Niles, IL: Oxford University Press</publisher><subject>Acetic acid ; Analysis ; Biological and medical sciences ; Blood ; Chromatography, Gas - methods ; Drugs ; Forensic science ; General pharmacology ; Humans ; Medical sciences ; Pharmaceutical Preparations - blood ; Pharmacology. 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An aliquot of the n-butyl acetate was injected into a gas chromatograph equipped with a nitrogen-phosphorous detector and a wide-bore cross-linked 50% phenylmethyl silicone capillary column. Absolute and relative retention times were recorded for more than 100 extracted drug standards. Recovery from whole blood was determined for some of the more frequently encountered drugs. This one-step extraction proved to be reliable for general screening and has been used routinely in forensic and clinical toxicological analyses.</description><subject>Acetic acid</subject><subject>Analysis</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Chromatography, Gas - methods</subject><subject>Drugs</subject><subject>Forensic science</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Pharmaceutical Preparations - blood</subject><subject>Pharmacology. Drug treatments</subject><subject>Silicones</subject><issn>0146-4760</issn><issn>1945-2403</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90E1PGzEQBmCroqIp7Y1rJR8Q6qGb-GP8sUcINFSKWqS0tOJiTbxeWNjsBnsjwb-vS6Ice5rD-2g08xJyzNmYs1JOHnCYcDmGsRDwhox4CaoQwOQBGTEOugCj2TvyPqUHxri2Wh6SQ2FMyQ2MyM0ZXTTdXRuKxRDW9PJ5iOiHpu9o3Ue68DGELuf0933fBnre9n31mpxjajy9iJu7RJcvdIrrpm0xvtDZdPL9-uIDeVtjm8LH3Twiv75e_pxeFfMfs2_Ts3nhgZuh0ErUFq3VYmltKURZgzIIChlaQDRYQYXgl2WFWEtUtjQSlAdpjUdmjTwip9u969g_bUIa3KpJPuRTutBvkuMKgDMjMvz8f5ibBK2skJl-2VIf-5RiqN06Nqv8W0avzuXGHZcOXG4880-7zZvlKlR7vKs45ye7HJPHto7Y-SbtmTagNPv3SbFlTRrC8z7G-JiJNMpd_bl1djZX5c21dAv5F1rplZI</recordid><startdate>19890701</startdate><enddate>19890701</enddate><creator>Cox, Robert A.</creator><creator>Crifasi, Joseph A.</creator><creator>Dickey, Ralph E.</creator><creator>Ketzler, Steven C.</creator><creator>Pshak, Gary L.</creator><general>Oxford University Press</general><general>Preston</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19890701</creationdate><title>A Single-Step Extraction for Screening Whole Blood for Basic Drugs by Capillary GC/NPD</title><author>Cox, Robert A. ; Crifasi, Joseph A. ; Dickey, Ralph E. ; Ketzler, Steven C. ; Pshak, Gary L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-652f8a8862b889229f457a45a0a84aa7ad4da4cb9daaf3a5897345c4387ca0873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Acetic acid</topic><topic>Analysis</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Chromatography, Gas - methods</topic><topic>Drugs</topic><topic>Forensic science</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Pharmaceutical Preparations - blood</topic><topic>Pharmacology. Drug treatments</topic><topic>Silicones</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cox, Robert A.</creatorcontrib><creatorcontrib>Crifasi, Joseph A.</creatorcontrib><creatorcontrib>Dickey, Ralph E.</creatorcontrib><creatorcontrib>Ketzler, Steven C.</creatorcontrib><creatorcontrib>Pshak, Gary L.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of analytical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cox, Robert A.</au><au>Crifasi, Joseph A.</au><au>Dickey, Ralph E.</au><au>Ketzler, Steven C.</au><au>Pshak, Gary L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Single-Step Extraction for Screening Whole Blood for Basic Drugs by Capillary GC/NPD</atitle><jtitle>Journal of analytical toxicology</jtitle><addtitle>Journal of Analytical Toxicology</addtitle><date>1989-07-01</date><risdate>1989</risdate><volume>13</volume><issue>4</issue><spage>224</spage><epage>228</epage><pages>224-228</pages><issn>0146-4760</issn><eissn>1945-2403</eissn><coden>JATOD3</coden><abstract>Basic drugs were routinely extracted from whole blood under alkaline conditions into n-butyl acetate. 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| fulltext | fulltext |
| identifier | ISSN: 0146-4760 |
| ispartof | Journal of analytical toxicology, 1989-07, Vol.13 (4), p.224-228 |
| issn | 0146-4760 1945-2403 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_15441072 |
| source | MEDLINE; Alma/SFX Local Collection; Oxford University Press Journals Digital Archive Legacy |
| subjects | Acetic acid Analysis Biological and medical sciences Blood Chromatography, Gas - methods Drugs Forensic science General pharmacology Humans Medical sciences Pharmaceutical Preparations - blood Pharmacology. Drug treatments Silicones |
| title | A Single-Step Extraction for Screening Whole Blood for Basic Drugs by Capillary GC/NPD |
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