Evaluation of P(L)LA-PEG-P(L)LA as processing aid for biodegradable particles from gas saturated solutions (PGSS) process
[Display omitted] A series of biodegradable P(L)LA-PEG1.5kDa-P(L)LA copolymers have been synthesized and compared as processing aid versus Poloxamer 407 (PEO–PPO–PEO), in the formulation of protein encapsulated microparticles, using supercritical carbon dioxide (scCO2). Bovine serum albumin (BSA) lo...
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| Veröffentlicht in: | International journal of pharmaceutics 2014-07, Vol.468 (1-2), p.250-257 |
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| container_title | International journal of pharmaceutics |
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| creator | Perinelli, D.R. Bonacucina, G. Cespi, M. Naylor, A. Whitaker, M. Palmieri, G.F. Giorgioni, G. Casettari, L. |
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A series of biodegradable P(L)LA-PEG1.5kDa-P(L)LA copolymers have been synthesized and compared as processing aid versus Poloxamer 407 (PEO–PPO–PEO), in the formulation of protein encapsulated microparticles, using supercritical carbon dioxide (scCO2). Bovine serum albumin (BSA) loaded microcarriers were prepared applying the particles from the gas saturated solutions (PGSS) technique using scCO2 and thus, avoiding the standard practice of organic solvent encapsulation. Four triblock copolymers were synthesized and characterized, particularly in terms of thermal properties and behaviour when exposed to scCO2. The effects of the inclusion of these copolymers in the formulation of poly(α-hydroxy acids) based microparticles – e.g. poly(d,l-lactic-co-glycolic acid) (PLGA) and poly(d,l-lactide) (PLA) – were analysed in terms of yield, particle size, morphology and drug release. The use of P(L)LA-PEG1.5kDa-P(L)LA triblock copolymers were found to increase the yield of the PGSS-based process and to decrease the size of the microparticles produced, in comparison with the formulation containing the Poloxamer 407. Moreover the microparticles formulated with the triblock copolymers possessing the higher hydrophobic character were able to maintain a controlled drug release profile. |
| doi_str_mv | 10.1016/j.ijpharm.2014.04.031 |
| format | Article |
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A series of biodegradable P(L)LA-PEG1.5kDa-P(L)LA copolymers have been synthesized and compared as processing aid versus Poloxamer 407 (PEO–PPO–PEO), in the formulation of protein encapsulated microparticles, using supercritical carbon dioxide (scCO2). Bovine serum albumin (BSA) loaded microcarriers were prepared applying the particles from the gas saturated solutions (PGSS) technique using scCO2 and thus, avoiding the standard practice of organic solvent encapsulation. Four triblock copolymers were synthesized and characterized, particularly in terms of thermal properties and behaviour when exposed to scCO2. The effects of the inclusion of these copolymers in the formulation of poly(α-hydroxy acids) based microparticles – e.g. poly(d,l-lactic-co-glycolic acid) (PLGA) and poly(d,l-lactide) (PLA) – were analysed in terms of yield, particle size, morphology and drug release. The use of P(L)LA-PEG1.5kDa-P(L)LA triblock copolymers were found to increase the yield of the PGSS-based process and to decrease the size of the microparticles produced, in comparison with the formulation containing the Poloxamer 407. Moreover the microparticles formulated with the triblock copolymers possessing the higher hydrophobic character were able to maintain a controlled drug release profile.</description><identifier>ISSN: 0378-5173</identifier><identifier>EISSN: 1873-3476</identifier><identifier>DOI: 10.1016/j.ijpharm.2014.04.031</identifier><identifier>PMID: 24746690</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Biodegradable microparticles ; Block copolymers ; BSA ; Carbon Dioxide ; Chemistry, Pharmaceutical ; Chromatography, Supercritical Fluid ; Delayed-Action Preparations ; Drug Carriers ; Gases ; Hydrophobic and Hydrophilic Interactions ; Kinetics ; Lactic Acid - chemical synthesis ; PGSS ; Poloxamer - chemical synthesis ; Polyesters ; Polyethylene Glycols - chemical synthesis ; Polyglycolic Acid - chemical synthesis ; Polymers - chemical synthesis ; Porosity ; scCO2 ; Serum Albumin, Bovine - chemistry ; Solubility ; Technology, Pharmaceutical - methods ; Viscosity</subject><ispartof>International journal of pharmaceutics, 2014-07, Vol.468 (1-2), p.250-257</ispartof><rights>2014 Elsevier B.V.</rights><rights>Copyright © 2014 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-8b81b799fc90007dde6567609e67da8025b2f8f01e30397036dfa3f0a1d431df3</citedby><cites>FETCH-LOGICAL-c464t-8b81b799fc90007dde6567609e67da8025b2f8f01e30397036dfa3f0a1d431df3</cites><orcidid>0000-0002-8528-4166</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijpharm.2014.04.031$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24746690$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Perinelli, D.R.</creatorcontrib><creatorcontrib>Bonacucina, G.</creatorcontrib><creatorcontrib>Cespi, M.</creatorcontrib><creatorcontrib>Naylor, A.</creatorcontrib><creatorcontrib>Whitaker, M.</creatorcontrib><creatorcontrib>Palmieri, G.F.</creatorcontrib><creatorcontrib>Giorgioni, G.</creatorcontrib><creatorcontrib>Casettari, L.</creatorcontrib><title>Evaluation of P(L)LA-PEG-P(L)LA as processing aid for biodegradable particles from gas saturated solutions (PGSS) process</title><title>International journal of pharmaceutics</title><addtitle>Int J Pharm</addtitle><description>[Display omitted]
A series of biodegradable P(L)LA-PEG1.5kDa-P(L)LA copolymers have been synthesized and compared as processing aid versus Poloxamer 407 (PEO–PPO–PEO), in the formulation of protein encapsulated microparticles, using supercritical carbon dioxide (scCO2). Bovine serum albumin (BSA) loaded microcarriers were prepared applying the particles from the gas saturated solutions (PGSS) technique using scCO2 and thus, avoiding the standard practice of organic solvent encapsulation. Four triblock copolymers were synthesized and characterized, particularly in terms of thermal properties and behaviour when exposed to scCO2. The effects of the inclusion of these copolymers in the formulation of poly(α-hydroxy acids) based microparticles – e.g. poly(d,l-lactic-co-glycolic acid) (PLGA) and poly(d,l-lactide) (PLA) – were analysed in terms of yield, particle size, morphology and drug release. The use of P(L)LA-PEG1.5kDa-P(L)LA triblock copolymers were found to increase the yield of the PGSS-based process and to decrease the size of the microparticles produced, in comparison with the formulation containing the Poloxamer 407. Moreover the microparticles formulated with the triblock copolymers possessing the higher hydrophobic character were able to maintain a controlled drug release profile.</description><subject>Biodegradable microparticles</subject><subject>Block copolymers</subject><subject>BSA</subject><subject>Carbon Dioxide</subject><subject>Chemistry, Pharmaceutical</subject><subject>Chromatography, Supercritical Fluid</subject><subject>Delayed-Action Preparations</subject><subject>Drug Carriers</subject><subject>Gases</subject><subject>Hydrophobic and Hydrophilic Interactions</subject><subject>Kinetics</subject><subject>Lactic Acid - chemical synthesis</subject><subject>PGSS</subject><subject>Poloxamer - chemical synthesis</subject><subject>Polyesters</subject><subject>Polyethylene Glycols - chemical synthesis</subject><subject>Polyglycolic Acid - chemical synthesis</subject><subject>Polymers - chemical synthesis</subject><subject>Porosity</subject><subject>scCO2</subject><subject>Serum Albumin, Bovine - chemistry</subject><subject>Solubility</subject><subject>Technology, Pharmaceutical - methods</subject><subject>Viscosity</subject><issn>0378-5173</issn><issn>1873-3476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUFrGzEQhUVoSNy0P6FFR-ewzmillXZPJQTXKRhqSHsW2tXIldm1XGk3kH8fGTu9NjAwc_jee0KPkC8MFgyYvNst_O7wx8RhUQITC8jD2QWZsVrxggslP5AZcFUXFVP8mnxMaQcAsmT8ilyXQgkpG5iRl-Wz6Scz-rCnwdHNfH27vi82y1VxOqlJ9BBDhyn5_ZYab6kLkbY-WNxGY03bIz2YOPqux0RdDAPdZk0y4xTNiJam0E9H-0Tnm9XT0-2b3Sdy6Uyf8PN535Df35e_Hh6L9c_Vj4f7ddEJKcaibmvWqqZxXZPfr6xFWUkloUGprKmhrNrS1Q4YcuCNAi6tM9yBYVZwZh2_IfOTb879O2Ea9eBTh31v9himpFklBDDVVOIdaNnUgguQGa1OaBdDShGdPkQ_mPiiGehjQXqnzwXpY0Ea8nCWdV_PEVM7oP2nemskA99OAOY_efYYdeo87ju0PmI3ahv8fyJeAdheopk</recordid><startdate>20140701</startdate><enddate>20140701</enddate><creator>Perinelli, D.R.</creator><creator>Bonacucina, G.</creator><creator>Cespi, M.</creator><creator>Naylor, A.</creator><creator>Whitaker, M.</creator><creator>Palmieri, G.F.</creator><creator>Giorgioni, G.</creator><creator>Casettari, L.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><orcidid>https://orcid.org/0000-0002-8528-4166</orcidid></search><sort><creationdate>20140701</creationdate><title>Evaluation of P(L)LA-PEG-P(L)LA as processing aid for biodegradable particles from gas saturated solutions (PGSS) process</title><author>Perinelli, D.R. ; Bonacucina, G. ; Cespi, M. ; Naylor, A. ; Whitaker, M. ; Palmieri, G.F. ; Giorgioni, G. ; Casettari, L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-8b81b799fc90007dde6567609e67da8025b2f8f01e30397036dfa3f0a1d431df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Biodegradable microparticles</topic><topic>Block copolymers</topic><topic>BSA</topic><topic>Carbon Dioxide</topic><topic>Chemistry, Pharmaceutical</topic><topic>Chromatography, Supercritical Fluid</topic><topic>Delayed-Action Preparations</topic><topic>Drug Carriers</topic><topic>Gases</topic><topic>Hydrophobic and Hydrophilic Interactions</topic><topic>Kinetics</topic><topic>Lactic Acid - chemical synthesis</topic><topic>PGSS</topic><topic>Poloxamer - chemical synthesis</topic><topic>Polyesters</topic><topic>Polyethylene Glycols - chemical synthesis</topic><topic>Polyglycolic Acid - chemical synthesis</topic><topic>Polymers - chemical synthesis</topic><topic>Porosity</topic><topic>scCO2</topic><topic>Serum Albumin, Bovine - chemistry</topic><topic>Solubility</topic><topic>Technology, Pharmaceutical - methods</topic><topic>Viscosity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Perinelli, D.R.</creatorcontrib><creatorcontrib>Bonacucina, G.</creatorcontrib><creatorcontrib>Cespi, M.</creatorcontrib><creatorcontrib>Naylor, A.</creatorcontrib><creatorcontrib>Whitaker, M.</creatorcontrib><creatorcontrib>Palmieri, G.F.</creatorcontrib><creatorcontrib>Giorgioni, G.</creatorcontrib><creatorcontrib>Casettari, L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>International journal of pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Perinelli, D.R.</au><au>Bonacucina, G.</au><au>Cespi, M.</au><au>Naylor, A.</au><au>Whitaker, M.</au><au>Palmieri, G.F.</au><au>Giorgioni, G.</au><au>Casettari, L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of P(L)LA-PEG-P(L)LA as processing aid for biodegradable particles from gas saturated solutions (PGSS) process</atitle><jtitle>International journal of pharmaceutics</jtitle><addtitle>Int J Pharm</addtitle><date>2014-07-01</date><risdate>2014</risdate><volume>468</volume><issue>1-2</issue><spage>250</spage><epage>257</epage><pages>250-257</pages><issn>0378-5173</issn><eissn>1873-3476</eissn><abstract>[Display omitted]
A series of biodegradable P(L)LA-PEG1.5kDa-P(L)LA copolymers have been synthesized and compared as processing aid versus Poloxamer 407 (PEO–PPO–PEO), in the formulation of protein encapsulated microparticles, using supercritical carbon dioxide (scCO2). Bovine serum albumin (BSA) loaded microcarriers were prepared applying the particles from the gas saturated solutions (PGSS) technique using scCO2 and thus, avoiding the standard practice of organic solvent encapsulation. Four triblock copolymers were synthesized and characterized, particularly in terms of thermal properties and behaviour when exposed to scCO2. The effects of the inclusion of these copolymers in the formulation of poly(α-hydroxy acids) based microparticles – e.g. poly(d,l-lactic-co-glycolic acid) (PLGA) and poly(d,l-lactide) (PLA) – were analysed in terms of yield, particle size, morphology and drug release. The use of P(L)LA-PEG1.5kDa-P(L)LA triblock copolymers were found to increase the yield of the PGSS-based process and to decrease the size of the microparticles produced, in comparison with the formulation containing the Poloxamer 407. Moreover the microparticles formulated with the triblock copolymers possessing the higher hydrophobic character were able to maintain a controlled drug release profile.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>24746690</pmid><doi>10.1016/j.ijpharm.2014.04.031</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-8528-4166</orcidid></addata></record> |
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| ispartof | International journal of pharmaceutics, 2014-07, Vol.468 (1-2), p.250-257 |
| issn | 0378-5173 1873-3476 |
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| subjects | Biodegradable microparticles Block copolymers BSA Carbon Dioxide Chemistry, Pharmaceutical Chromatography, Supercritical Fluid Delayed-Action Preparations Drug Carriers Gases Hydrophobic and Hydrophilic Interactions Kinetics Lactic Acid - chemical synthesis PGSS Poloxamer - chemical synthesis Polyesters Polyethylene Glycols - chemical synthesis Polyglycolic Acid - chemical synthesis Polymers - chemical synthesis Porosity scCO2 Serum Albumin, Bovine - chemistry Solubility Technology, Pharmaceutical - methods Viscosity |
| title | Evaluation of P(L)LA-PEG-P(L)LA as processing aid for biodegradable particles from gas saturated solutions (PGSS) process |
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