α-Crystallin protects RGC survival and inhibits microglial activation after optic nerve crush

Activation of retinal microglial cells (RMCs) is known to contribute to retinal ganglion cell (RGC) death after optic nerve injury. The purpose of this study was to investigate the effects of intravenous injection of α-crystallin on RGC survival and RMC activation in a rat model of optic nerve crush...

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Veröffentlicht in:	Life sciences (1973) 2014-01, Vol.94 (1), p.17-23
Hauptverfasser:	Wu, Nan, Yu, Jia, Chen, Shaojun, Xu, Jiangning, Ying, Xi, Ye, Mao, Li, Yiru, Wang, Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Crystallins - administration & dosage alpha-Crystallins - pharmacology Animals Blotting, Western Cell Survival - drug effects Crystallin Disease Models, Animal Dose-Response Relationship, Drug Female Fluorescent Antibody Technique Injections, Intravenous Male Microglia - drug effects Microglia - metabolism Microscopy, Confocal Microscopy, Fluorescence Nerve Crush Nitric Oxide Synthase Type II - genetics Optic Nerve Injuries - drug therapy Optic Nerve Injuries - pathology Optic nerve injury Rats Rats, Long-Evans Retinal ganglion cell Retinal Ganglion Cells - drug effects Retinal Ganglion Cells - metabolism Retinal microglial activation Time Factors Tumor Necrosis Factor-alpha - genetics
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