Sinularosides A and B, Bioactive 9,11-Secosteroidal Glycosides from the South China Sea Soft Coral Sinularia humilis Ofwegen
Two new 9,11-secosteroidal glycosides, namely, sinularosides A and B (1, 2), together with the known pregnene glycoside 3β-(β-xylopyranosyloxy)-5α-pregna-20-ene (3), were isolated from the South China Sea soft coral Sinularia humilis Ofwegen. The structures of these compounds were elucidated by a co...
Gespeichert in:
| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 2012-09, Vol.75 (9), p.1656-1659 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1659 |
|---|---|
| container_issue | 9 |
| container_start_page | 1656 |
| container_title | Journal of natural products (Washington, D.C.) |
| container_volume | 75 |
| creator | Sun, Peng Meng, Li-Yuan Tang, Hua Liu, Bao-Shu Li, Ling Yi, Yanghua Zhang, Wen |
| description | Two new 9,11-secosteroidal glycosides, namely, sinularosides A and B (1, 2), together with the known pregnene glycoside 3β-(β-xylopyranosyloxy)-5α-pregna-20-ene (3), were isolated from the South China Sea soft coral Sinularia humilis Ofwegen. The structures of these compounds were elucidated by a combination of detailed spectroscopic analyses, chemical methods, and comparison with reported data. This is the first report of 9,11-secosteroidal glycosides from a soft coral and from nature. In in vitro bioassays, the new compounds exhibited potent antimicrobial activities and showed no growth inhibition activity against the tumor cells HepG2 and Caco-2. |
| doi_str_mv | 10.1021/np300475d |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1544017490</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1544017490</sourcerecordid><originalsourceid>FETCH-LOGICAL-a414t-8b2600782af484cdf39fdd600993141e57f88680920c21bea6e993d40916db193</originalsourceid><addsrcrecordid>eNqF0U1LHDEYB_AgLbq-HPwCJZeCgmOfvExmctRFrbCwh9XzkJ086UZmJttkpkXwwzdlt54KHkIg-eUfeP6EnDO4ZsDZt2ErAGRV2gMyYyWHQgEvP5EZMCUKUSt5RI5TegEAAbo8JEeca6mUkDPytvLD1JkYkreY6A01g6W3V_TWB9OO_hdSfcVYscI2pBFj8NZ09KF7bfcPXAw9HTdIV2EaN3S-8YOhK8wruJHOQ8x8_4U3dDP1vvOJLt1v_IHDKfnsTJfwbL-fkOf7u6f592KxfHic3ywKI5kci3rNFUBVc-NkLVvrhHbW5iOtBZMMy8rVtapBc2g5W6NRmG-sBM2UXTMtTsjFLncbw88J09j0PrXYdWbAMKWGlVICq6SGjynUTIpKSZnp5Y62eXopomu20fcmvmbU_O2lee8l2y_72Gndo32X_4rI4OsOmDY1L2GKQx7If4L-AN8mkiY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1081437644</pqid></control><display><type>article</type><title>Sinularosides A and B, Bioactive 9,11-Secosteroidal Glycosides from the South China Sea Soft Coral Sinularia humilis Ofwegen</title><source>ACS Publications</source><source>MEDLINE</source><creator>Sun, Peng ; Meng, Li-Yuan ; Tang, Hua ; Liu, Bao-Shu ; Li, Ling ; Yi, Yanghua ; Zhang, Wen</creator><creatorcontrib>Sun, Peng ; Meng, Li-Yuan ; Tang, Hua ; Liu, Bao-Shu ; Li, Ling ; Yi, Yanghua ; Zhang, Wen</creatorcontrib><description>Two new 9,11-secosteroidal glycosides, namely, sinularosides A and B (1, 2), together with the known pregnene glycoside 3β-(β-xylopyranosyloxy)-5α-pregna-20-ene (3), were isolated from the South China Sea soft coral Sinularia humilis Ofwegen. The structures of these compounds were elucidated by a combination of detailed spectroscopic analyses, chemical methods, and comparison with reported data. This is the first report of 9,11-secosteroidal glycosides from a soft coral and from nature. In in vitro bioassays, the new compounds exhibited potent antimicrobial activities and showed no growth inhibition activity against the tumor cells HepG2 and Caco-2.</description><identifier>ISSN: 0163-3864</identifier><identifier>EISSN: 1520-6025</identifier><identifier>DOI: 10.1021/np300475d</identifier><identifier>PMID: 22946634</identifier><language>eng</language><publisher>United States: American Chemical Society and American Society of Pharmacognosy</publisher><subject>Animals ; Anthozoa - chemistry ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - isolation & purification ; Antineoplastic Agents - pharmacology ; Caco-2 Cells ; China ; Drug Screening Assays, Antitumor ; Glycosides - chemistry ; Glycosides - isolation & purification ; Glycosides - pharmacology ; Hep G2 Cells ; Humans ; Molecular Structure ; Oceans and Seas ; Secosteroids - chemistry ; Secosteroids - isolation & purification ; Secosteroids - pharmacology ; Sinularia</subject><ispartof>Journal of natural products (Washington, D.C.), 2012-09, Vol.75 (9), p.1656-1659</ispartof><rights>Copyright © 2012 American Chemical Society and American Society of Pharmacognosy</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a414t-8b2600782af484cdf39fdd600993141e57f88680920c21bea6e993d40916db193</citedby><cites>FETCH-LOGICAL-a414t-8b2600782af484cdf39fdd600993141e57f88680920c21bea6e993d40916db193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/np300475d$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/np300475d$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22946634$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, Peng</creatorcontrib><creatorcontrib>Meng, Li-Yuan</creatorcontrib><creatorcontrib>Tang, Hua</creatorcontrib><creatorcontrib>Liu, Bao-Shu</creatorcontrib><creatorcontrib>Li, Ling</creatorcontrib><creatorcontrib>Yi, Yanghua</creatorcontrib><creatorcontrib>Zhang, Wen</creatorcontrib><title>Sinularosides A and B, Bioactive 9,11-Secosteroidal Glycosides from the South China Sea Soft Coral Sinularia humilis Ofwegen</title><title>Journal of natural products (Washington, D.C.)</title><addtitle>J. Nat. Prod</addtitle><description>Two new 9,11-secosteroidal glycosides, namely, sinularosides A and B (1, 2), together with the known pregnene glycoside 3β-(β-xylopyranosyloxy)-5α-pregna-20-ene (3), were isolated from the South China Sea soft coral Sinularia humilis Ofwegen. The structures of these compounds were elucidated by a combination of detailed spectroscopic analyses, chemical methods, and comparison with reported data. This is the first report of 9,11-secosteroidal glycosides from a soft coral and from nature. In in vitro bioassays, the new compounds exhibited potent antimicrobial activities and showed no growth inhibition activity against the tumor cells HepG2 and Caco-2.</description><subject>Animals</subject><subject>Anthozoa - chemistry</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - isolation & purification</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Caco-2 Cells</subject><subject>China</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Glycosides - chemistry</subject><subject>Glycosides - isolation & purification</subject><subject>Glycosides - pharmacology</subject><subject>Hep G2 Cells</subject><subject>Humans</subject><subject>Molecular Structure</subject><subject>Oceans and Seas</subject><subject>Secosteroids - chemistry</subject><subject>Secosteroids - isolation & purification</subject><subject>Secosteroids - pharmacology</subject><subject>Sinularia</subject><issn>0163-3864</issn><issn>1520-6025</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0U1LHDEYB_AgLbq-HPwCJZeCgmOfvExmctRFrbCwh9XzkJ086UZmJttkpkXwwzdlt54KHkIg-eUfeP6EnDO4ZsDZt2ErAGRV2gMyYyWHQgEvP5EZMCUKUSt5RI5TegEAAbo8JEeca6mUkDPytvLD1JkYkreY6A01g6W3V_TWB9OO_hdSfcVYscI2pBFj8NZ09KF7bfcPXAw9HTdIV2EaN3S-8YOhK8wruJHOQ8x8_4U3dDP1vvOJLt1v_IHDKfnsTJfwbL-fkOf7u6f592KxfHic3ywKI5kci3rNFUBVc-NkLVvrhHbW5iOtBZMMy8rVtapBc2g5W6NRmG-sBM2UXTMtTsjFLncbw88J09j0PrXYdWbAMKWGlVICq6SGjynUTIpKSZnp5Y62eXopomu20fcmvmbU_O2lee8l2y_72Gndo32X_4rI4OsOmDY1L2GKQx7If4L-AN8mkiY</recordid><startdate>20120928</startdate><enddate>20120928</enddate><creator>Sun, Peng</creator><creator>Meng, Li-Yuan</creator><creator>Tang, Hua</creator><creator>Liu, Bao-Shu</creator><creator>Li, Ling</creator><creator>Yi, Yanghua</creator><creator>Zhang, Wen</creator><general>American Chemical Society and American Society of Pharmacognosy</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TN</scope><scope>8FD</scope><scope>F1W</scope><scope>FR3</scope><scope>H95</scope><scope>H99</scope><scope>L.F</scope><scope>L.G</scope><scope>P64</scope></search><sort><creationdate>20120928</creationdate><title>Sinularosides A and B, Bioactive 9,11-Secosteroidal Glycosides from the South China Sea Soft Coral Sinularia humilis Ofwegen</title><author>Sun, Peng ; Meng, Li-Yuan ; Tang, Hua ; Liu, Bao-Shu ; Li, Ling ; Yi, Yanghua ; Zhang, Wen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a414t-8b2600782af484cdf39fdd600993141e57f88680920c21bea6e993d40916db193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Anthozoa - chemistry</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - isolation & purification</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Caco-2 Cells</topic><topic>China</topic><topic>Drug Screening Assays, Antitumor</topic><topic>Glycosides - chemistry</topic><topic>Glycosides - isolation & purification</topic><topic>Glycosides - pharmacology</topic><topic>Hep G2 Cells</topic><topic>Humans</topic><topic>Molecular Structure</topic><topic>Oceans and Seas</topic><topic>Secosteroids - chemistry</topic><topic>Secosteroids - isolation & purification</topic><topic>Secosteroids - pharmacology</topic><topic>Sinularia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Peng</creatorcontrib><creatorcontrib>Meng, Li-Yuan</creatorcontrib><creatorcontrib>Tang, Hua</creatorcontrib><creatorcontrib>Liu, Bao-Shu</creatorcontrib><creatorcontrib>Li, Ling</creatorcontrib><creatorcontrib>Yi, Yanghua</creatorcontrib><creatorcontrib>Zhang, Wen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Oceanic Abstracts</collection><collection>Technology Research Database</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>ASFA: Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of natural products (Washington, D.C.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Peng</au><au>Meng, Li-Yuan</au><au>Tang, Hua</au><au>Liu, Bao-Shu</au><au>Li, Ling</au><au>Yi, Yanghua</au><au>Zhang, Wen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sinularosides A and B, Bioactive 9,11-Secosteroidal Glycosides from the South China Sea Soft Coral Sinularia humilis Ofwegen</atitle><jtitle>Journal of natural products (Washington, D.C.)</jtitle><addtitle>J. Nat. Prod</addtitle><date>2012-09-28</date><risdate>2012</risdate><volume>75</volume><issue>9</issue><spage>1656</spage><epage>1659</epage><pages>1656-1659</pages><issn>0163-3864</issn><eissn>1520-6025</eissn><abstract>Two new 9,11-secosteroidal glycosides, namely, sinularosides A and B (1, 2), together with the known pregnene glycoside 3β-(β-xylopyranosyloxy)-5α-pregna-20-ene (3), were isolated from the South China Sea soft coral Sinularia humilis Ofwegen. The structures of these compounds were elucidated by a combination of detailed spectroscopic analyses, chemical methods, and comparison with reported data. This is the first report of 9,11-secosteroidal glycosides from a soft coral and from nature. In in vitro bioassays, the new compounds exhibited potent antimicrobial activities and showed no growth inhibition activity against the tumor cells HepG2 and Caco-2.</abstract><cop>United States</cop><pub>American Chemical Society and American Society of Pharmacognosy</pub><pmid>22946634</pmid><doi>10.1021/np300475d</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0163-3864 |
| ispartof | Journal of natural products (Washington, D.C.), 2012-09, Vol.75 (9), p.1656-1659 |
| issn | 0163-3864 1520-6025 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1544017490 |
| source | ACS Publications; MEDLINE |
| subjects | Animals Anthozoa - chemistry Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Caco-2 Cells China Drug Screening Assays, Antitumor Glycosides - chemistry Glycosides - isolation & purification Glycosides - pharmacology Hep G2 Cells Humans Molecular Structure Oceans and Seas Secosteroids - chemistry Secosteroids - isolation & purification Secosteroids - pharmacology Sinularia |
| title | Sinularosides A and B, Bioactive 9,11-Secosteroidal Glycosides from the South China Sea Soft Coral Sinularia humilis Ofwegen |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T02%3A26%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Sinularosides%20A%20and%20B,%20Bioactive%209,11-Secosteroidal%20Glycosides%20from%20the%20South%20China%20Sea%20Soft%20Coral%20Sinularia%20humilis%20Ofwegen&rft.jtitle=Journal%20of%20natural%20products%20(Washington,%20D.C.)&rft.au=Sun,%20Peng&rft.date=2012-09-28&rft.volume=75&rft.issue=9&rft.spage=1656&rft.epage=1659&rft.pages=1656-1659&rft.issn=0163-3864&rft.eissn=1520-6025&rft_id=info:doi/10.1021/np300475d&rft_dat=%3Cproquest_cross%3E1544017490%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1081437644&rft_id=info:pmid/22946634&rfr_iscdi=true |