Functional analysis of [methyl-3H]choline uptake in glioblastoma cells: Influence of anti-cancer and central nervous system drugs

Positron emission tomography (PET) and PET/computed tomography (PET-CT) studies with 11C- or 18F-labeled choline derivatives are used for PET imaging in glioblastoma patients. However, the nature of the choline transport system in glioblastoma is poorly understood. In this study, we performed a func...

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Veröffentlicht in:	Biochemical pharmacology 2014-04, Vol.88 (3), p.303-312
Hauptverfasser:	Taguchi, Chiaki, Inazu, Masato, Saiki, Iwao, Yara, Miki, Hara, Naomi, Yamanaka, Tsuyoshi, Uchino, Hiroyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD - genetics Antigens, CD - metabolism Antineoplastic Agents - pharmacology Astrocytes - metabolism Cell Line, Tumor Cell Survival - drug effects Central Nervous System Agents - pharmacology Choline Choline - metabolism Choline PET Extracellular Space - chemistry Glioblastoma - metabolism Glioblastoma cells Humans Hydrogen-Ion Concentration Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Membrane Transport Proteins - genetics Membrane Transport Proteins - metabolism Organic Cation Transport Proteins - genetics Organic Cation Transport Proteins - metabolism Radiopharmaceuticals - metabolism RNA, Messenger - metabolism Symporters - genetics Symporters - metabolism Transporter Tritium
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