SIRT6 Regulates Osteogenic Differentiation of Rat Bone Marrow Mesenchymal Stem Cells Partially via Suppressing the Nuclear Factor-[kappa]B Signaling Pathway

Sirtuin 6 (SIRT6) is a NAD-dependent deacetylase involved in lifespan regulation. To evaluate the effect of SIRT6 on osteogenesis, rat bone marrow mesenchymal stem cells (rBMSCs) with enhanced or reduced SIRT6 function were developed. We observed that SIRT6 knockdown significantly reduced the mRNA l...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 2014-07, Vol.32 (7), p.1943-1955
Hauptverfasser:	Sun, Hualing, Wu, Yanru, Fu, Dongjie, Liu, Yinchen, Huang, Cui
Format:	Artikel
Sprache:	eng
Schlagworte:	Bone marrow Stem cells
Online-Zugang:	Volltext
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