Feasibility of corneal drug delivery of cysteamine using vitamin E modified silicone hydrogel contact lenses

Cystinosis is an inherited genetic disease characterized by the accumulation of cystine crystals in several tissues including the cornea. The corneal manifestations of cystinosis are treated by hourly instillation of cysteamine eye drops each day while awake. The high frequency of eye drop instillat...

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Veröffentlicht in:	European journal of pharmaceutics and biopharmaceutics 2013-11, Vol.85 (3), p.531-540
Hauptverfasser:	Hsu, Kuan-Hui, Fentzke, Richard C., Chauhan, Anuj
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Ophthalmic Biological Availability Biological Transport Contact Lenses Cornea - metabolism Cysteamine Cysteamine - administration & dosage Cysteamine - pharmacokinetics Cystinosis Diffusion Drug Delivery Systems Drug Stability Extended drug delivery Feasibility Studies Hydrogels Models, Theoretical Ophthalmic Solutions Silicones - chemistry Time Factors Vitamin E Vitamin E - chemistry
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