Valproic acid suppresses lipopolysaccharide-induced cyclooxygenase-2 expression via MKP-1 in murine brain microvascular endothelial cells

Inflammation and vascular perturbations are increasingly implicated in the pathogenesis of neurodegenerative diseases. Prevailing evidence suggests that valproic acid (VPA), an antiepileptic and mood stabilizer, exhibits not only neuro-protective effects, but also anti-inflammatory effects in neurod...

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Veröffentlicht in:	Biochemical pharmacology 2014-04, Vol.88 (3), p.372-383
Hauptverfasser:	Chuang, Yu-Fan, Yang, Hung-Yu, Ko, Tsui-Ling, Hsu, Ya-Fen, Sheu, Joen-Rong, Ou, George, Hsu, Ming-Jen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Brain - blood supply Brain microvascular endothelial cells CCAAT-Enhancer-Binding Protein-beta - metabolism Cell Line Cyclooxygenase 2 - genetics Cyclooxygenase 2 - metabolism Cyclooxygenase-2 (COX-2) Dual Specificity Phosphatase 1 - metabolism Endothelial Cells - drug effects Endothelial Cells - enzymology JNK Mitogen-Activated Protein Kinases - metabolism Lipopolysaccharides - pharmacology Mice Microvessels - drug effects Microvessels - enzymology Mitogen-activated protein kinase phosphatase-1 (MKP-1) p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation Promoter Regions, Genetic Transcription Factor RelA - metabolism Valproic acid (VPA) Valproic Acid - pharmacology
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