S100B and NSE as useful postmortem biochemical markers of traumatic brain injury in autopsy cases
Postmortem analysis of relevant biomarkers might aid in characterizing causes of death and survival times in legal medicine. However, there are still no sufficiently established results of practical postmortem biochemical investigations in cases of traumatic brain injury (TBI). The two biomarkers--S...
Gespeichert in:
| Veröffentlicht in: | Journal of neurotrauma 2013-11, Vol.30 (22), p.1862-1871 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1871 |
|---|---|
| container_issue | 22 |
| container_start_page | 1862 |
| container_title | Journal of neurotrauma |
| container_volume | 30 |
| creator | Ondruschka, Benjamin Pohlers, Dirk Sommer, Gerald Schober, Kristin Teupser, Daniel Franke, Heike Dressler, Jan |
| description | Postmortem analysis of relevant biomarkers might aid in characterizing causes of death and survival times in legal medicine. However, there are still no sufficiently established results of practical postmortem biochemical investigations in cases of traumatic brain injury (TBI). The two biomarkers--S100 protein subunit B (S100B) and neuronal specific enolase (NSE)--could be of special interest. Therefore, the aim of the present study was to investigate changes in their postmortem levels for further determination of brain damage in TBI. In 17 cases of TBI (average age, 58 years) and in 23 controls with different causes of death (average age, 59 years), serum and cerebrospinal fluid (CSF) samples were analyzed with a chemiluminescence immunoassay for marker expression. An increase in serum S100B, as well as a subsequent decrease after survival times>4 days, were detected in TBI cases (p6,000 ng/mL and CSF S100B levels >10,000 ng/mL seem to indicate a TBI survival time of at least 15 min (p |
| doi_str_mv | 10.1089/neu.2013.2895 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1544014809</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1544014809</sourcerecordid><originalsourceid>FETCH-LOGICAL-c354t-e48a1bd16442683a198a1f523ca4da296bbdee2458f394d381ee7a97cdafcba13</originalsourceid><addsrcrecordid>eNqF0TFv1DAUwHELFdFrYWRFlrqw5PCzndgeaVXaSlUZCnP04ryIHEl82PFw3x6fWhi6dHqy_NOT7D9jH0FsQVj3ZaG8lQLUVlpXv2EbqGtTOaHlCduUe1MZqOGUnaW0E4U10rxjp1IZ14A1G4aPIMQlx6XnD4_XHBPPiYY88X1I6xziSjPvxuB_0Tx6nPiM8TfFxMPA14h5xnX0vIs4LnxcdjkeyuCY17BPB-4xUXrP3g44JfrwPM_Zz2_XP65uq_vvN3dXX-8rr2q9VqQtQtdDo7VsrEJw5TzUUnnUPUrXdF1PJHVtB-V0rywQGXTG9zj4DkGds89Pe_cx_MmU1nYek6dpwoVCTi3UWgvQVrjXqdZWAgjdFHrxgu5Cjkt5SFGN0UrKxhRVPSkfQ0qRhnYfx_JVhxZEe8zUlkztMVN7zFT8p-etuZup_6__dVF_ASP3jRc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1467432267</pqid></control><display><type>article</type><title>S100B and NSE as useful postmortem biochemical markers of traumatic brain injury in autopsy cases</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Ondruschka, Benjamin ; Pohlers, Dirk ; Sommer, Gerald ; Schober, Kristin ; Teupser, Daniel ; Franke, Heike ; Dressler, Jan</creator><creatorcontrib>Ondruschka, Benjamin ; Pohlers, Dirk ; Sommer, Gerald ; Schober, Kristin ; Teupser, Daniel ; Franke, Heike ; Dressler, Jan</creatorcontrib><description>Postmortem analysis of relevant biomarkers might aid in characterizing causes of death and survival times in legal medicine. However, there are still no sufficiently established results of practical postmortem biochemical investigations in cases of traumatic brain injury (TBI). The two biomarkers--S100 protein subunit B (S100B) and neuronal specific enolase (NSE)--could be of special interest. Therefore, the aim of the present study was to investigate changes in their postmortem levels for further determination of brain damage in TBI. In 17 cases of TBI (average age, 58 years) and in 23 controls with different causes of death (average age, 59 years), serum and cerebrospinal fluid (CSF) samples were analyzed with a chemiluminescence immunoassay for marker expression. An increase in serum S100B, as well as a subsequent decrease after survival times>4 days, were detected in TBI cases (p<0.01). CSF NSE values >6,000 ng/mL and CSF S100B levels >10,000 ng/mL seem to indicate a TBI survival time of at least 15 min (p<0.01). It is of particular interest that CSF S100B levels (p<0.01) and serum S100B levels (p<0.05) as well as CSF NSE values (p<0.01) were significantly higher in TBI cases in comparison to the controls, especially when compared with fatal non-head injuries. In conclusion, the present findings emphasize that S100B and NSE are useful markers in postmortem biochemistry in cases of suspected TBI. Further, S100B may be helpful to estimate the survival time of fatal injuries in legal medicine.</description><identifier>ISSN: 0897-7151</identifier><identifier>EISSN: 1557-9042</identifier><identifier>DOI: 10.1089/neu.2013.2895</identifier><identifier>PMID: 23796187</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Autopsies ; Autopsy ; Biochemistry ; Biomarkers ; Brain damage ; Brain Injuries - blood ; Brain Injuries - cerebrospinal fluid ; Brain Injuries - pathology ; Cause of Death ; Female ; Humans ; Male ; Middle Aged ; Phosphopyruvate Hydratase - blood ; Phosphopyruvate Hydratase - cerebrospinal fluid ; S100 Calcium Binding Protein beta Subunit - blood ; S100 Calcium Binding Protein beta Subunit - cerebrospinal fluid ; Survival Analysis ; Time Factors ; Trauma ; Young Adult</subject><ispartof>Journal of neurotrauma, 2013-11, Vol.30 (22), p.1862-1871</ispartof><rights>(©) Copyright 2013, Mary Ann Liebert, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-e48a1bd16442683a198a1f523ca4da296bbdee2458f394d381ee7a97cdafcba13</citedby><cites>FETCH-LOGICAL-c354t-e48a1bd16442683a198a1f523ca4da296bbdee2458f394d381ee7a97cdafcba13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23796187$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ondruschka, Benjamin</creatorcontrib><creatorcontrib>Pohlers, Dirk</creatorcontrib><creatorcontrib>Sommer, Gerald</creatorcontrib><creatorcontrib>Schober, Kristin</creatorcontrib><creatorcontrib>Teupser, Daniel</creatorcontrib><creatorcontrib>Franke, Heike</creatorcontrib><creatorcontrib>Dressler, Jan</creatorcontrib><title>S100B and NSE as useful postmortem biochemical markers of traumatic brain injury in autopsy cases</title><title>Journal of neurotrauma</title><addtitle>J Neurotrauma</addtitle><description>Postmortem analysis of relevant biomarkers might aid in characterizing causes of death and survival times in legal medicine. However, there are still no sufficiently established results of practical postmortem biochemical investigations in cases of traumatic brain injury (TBI). The two biomarkers--S100 protein subunit B (S100B) and neuronal specific enolase (NSE)--could be of special interest. Therefore, the aim of the present study was to investigate changes in their postmortem levels for further determination of brain damage in TBI. In 17 cases of TBI (average age, 58 years) and in 23 controls with different causes of death (average age, 59 years), serum and cerebrospinal fluid (CSF) samples were analyzed with a chemiluminescence immunoassay for marker expression. An increase in serum S100B, as well as a subsequent decrease after survival times>4 days, were detected in TBI cases (p<0.01). CSF NSE values >6,000 ng/mL and CSF S100B levels >10,000 ng/mL seem to indicate a TBI survival time of at least 15 min (p<0.01). It is of particular interest that CSF S100B levels (p<0.01) and serum S100B levels (p<0.05) as well as CSF NSE values (p<0.01) were significantly higher in TBI cases in comparison to the controls, especially when compared with fatal non-head injuries. In conclusion, the present findings emphasize that S100B and NSE are useful markers in postmortem biochemistry in cases of suspected TBI. Further, S100B may be helpful to estimate the survival time of fatal injuries in legal medicine.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Autopsies</subject><subject>Autopsy</subject><subject>Biochemistry</subject><subject>Biomarkers</subject><subject>Brain damage</subject><subject>Brain Injuries - blood</subject><subject>Brain Injuries - cerebrospinal fluid</subject><subject>Brain Injuries - pathology</subject><subject>Cause of Death</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Phosphopyruvate Hydratase - blood</subject><subject>Phosphopyruvate Hydratase - cerebrospinal fluid</subject><subject>S100 Calcium Binding Protein beta Subunit - blood</subject><subject>S100 Calcium Binding Protein beta Subunit - cerebrospinal fluid</subject><subject>Survival Analysis</subject><subject>Time Factors</subject><subject>Trauma</subject><subject>Young Adult</subject><issn>0897-7151</issn><issn>1557-9042</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqF0TFv1DAUwHELFdFrYWRFlrqw5PCzndgeaVXaSlUZCnP04ryIHEl82PFw3x6fWhi6dHqy_NOT7D9jH0FsQVj3ZaG8lQLUVlpXv2EbqGtTOaHlCduUe1MZqOGUnaW0E4U10rxjp1IZ14A1G4aPIMQlx6XnD4_XHBPPiYY88X1I6xziSjPvxuB_0Tx6nPiM8TfFxMPA14h5xnX0vIs4LnxcdjkeyuCY17BPB-4xUXrP3g44JfrwPM_Zz2_XP65uq_vvN3dXX-8rr2q9VqQtQtdDo7VsrEJw5TzUUnnUPUrXdF1PJHVtB-V0rywQGXTG9zj4DkGds89Pe_cx_MmU1nYek6dpwoVCTi3UWgvQVrjXqdZWAgjdFHrxgu5Cjkt5SFGN0UrKxhRVPSkfQ0qRhnYfx_JVhxZEe8zUlkztMVN7zFT8p-etuZup_6__dVF_ASP3jRc</recordid><startdate>20131115</startdate><enddate>20131115</enddate><creator>Ondruschka, Benjamin</creator><creator>Pohlers, Dirk</creator><creator>Sommer, Gerald</creator><creator>Schober, Kristin</creator><creator>Teupser, Daniel</creator><creator>Franke, Heike</creator><creator>Dressler, Jan</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20131115</creationdate><title>S100B and NSE as useful postmortem biochemical markers of traumatic brain injury in autopsy cases</title><author>Ondruschka, Benjamin ; Pohlers, Dirk ; Sommer, Gerald ; Schober, Kristin ; Teupser, Daniel ; Franke, Heike ; Dressler, Jan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-e48a1bd16442683a198a1f523ca4da296bbdee2458f394d381ee7a97cdafcba13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Autopsies</topic><topic>Autopsy</topic><topic>Biochemistry</topic><topic>Biomarkers</topic><topic>Brain damage</topic><topic>Brain Injuries - blood</topic><topic>Brain Injuries - cerebrospinal fluid</topic><topic>Brain Injuries - pathology</topic><topic>Cause of Death</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Phosphopyruvate Hydratase - blood</topic><topic>Phosphopyruvate Hydratase - cerebrospinal fluid</topic><topic>S100 Calcium Binding Protein beta Subunit - blood</topic><topic>S100 Calcium Binding Protein beta Subunit - cerebrospinal fluid</topic><topic>Survival Analysis</topic><topic>Time Factors</topic><topic>Trauma</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ondruschka, Benjamin</creatorcontrib><creatorcontrib>Pohlers, Dirk</creatorcontrib><creatorcontrib>Sommer, Gerald</creatorcontrib><creatorcontrib>Schober, Kristin</creatorcontrib><creatorcontrib>Teupser, Daniel</creatorcontrib><creatorcontrib>Franke, Heike</creatorcontrib><creatorcontrib>Dressler, Jan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurotrauma</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ondruschka, Benjamin</au><au>Pohlers, Dirk</au><au>Sommer, Gerald</au><au>Schober, Kristin</au><au>Teupser, Daniel</au><au>Franke, Heike</au><au>Dressler, Jan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>S100B and NSE as useful postmortem biochemical markers of traumatic brain injury in autopsy cases</atitle><jtitle>Journal of neurotrauma</jtitle><addtitle>J Neurotrauma</addtitle><date>2013-11-15</date><risdate>2013</risdate><volume>30</volume><issue>22</issue><spage>1862</spage><epage>1871</epage><pages>1862-1871</pages><issn>0897-7151</issn><eissn>1557-9042</eissn><abstract>Postmortem analysis of relevant biomarkers might aid in characterizing causes of death and survival times in legal medicine. However, there are still no sufficiently established results of practical postmortem biochemical investigations in cases of traumatic brain injury (TBI). The two biomarkers--S100 protein subunit B (S100B) and neuronal specific enolase (NSE)--could be of special interest. Therefore, the aim of the present study was to investigate changes in their postmortem levels for further determination of brain damage in TBI. In 17 cases of TBI (average age, 58 years) and in 23 controls with different causes of death (average age, 59 years), serum and cerebrospinal fluid (CSF) samples were analyzed with a chemiluminescence immunoassay for marker expression. An increase in serum S100B, as well as a subsequent decrease after survival times>4 days, were detected in TBI cases (p<0.01). CSF NSE values >6,000 ng/mL and CSF S100B levels >10,000 ng/mL seem to indicate a TBI survival time of at least 15 min (p<0.01). It is of particular interest that CSF S100B levels (p<0.01) and serum S100B levels (p<0.05) as well as CSF NSE values (p<0.01) were significantly higher in TBI cases in comparison to the controls, especially when compared with fatal non-head injuries. In conclusion, the present findings emphasize that S100B and NSE are useful markers in postmortem biochemistry in cases of suspected TBI. Further, S100B may be helpful to estimate the survival time of fatal injuries in legal medicine.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>23796187</pmid><doi>10.1089/neu.2013.2895</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0897-7151 |
| ispartof | Journal of neurotrauma, 2013-11, Vol.30 (22), p.1862-1871 |
| issn | 0897-7151 1557-9042 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1544014809 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Aged Aged, 80 and over Autopsies Autopsy Biochemistry Biomarkers Brain damage Brain Injuries - blood Brain Injuries - cerebrospinal fluid Brain Injuries - pathology Cause of Death Female Humans Male Middle Aged Phosphopyruvate Hydratase - blood Phosphopyruvate Hydratase - cerebrospinal fluid S100 Calcium Binding Protein beta Subunit - blood S100 Calcium Binding Protein beta Subunit - cerebrospinal fluid Survival Analysis Time Factors Trauma Young Adult |
| title | S100B and NSE as useful postmortem biochemical markers of traumatic brain injury in autopsy cases |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-19T06%3A41%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=S100B%20and%20NSE%20as%20useful%20postmortem%20biochemical%20markers%20of%20traumatic%20brain%20injury%20in%20autopsy%20cases&rft.jtitle=Journal%20of%20neurotrauma&rft.au=Ondruschka,%20Benjamin&rft.date=2013-11-15&rft.volume=30&rft.issue=22&rft.spage=1862&rft.epage=1871&rft.pages=1862-1871&rft.issn=0897-7151&rft.eissn=1557-9042&rft_id=info:doi/10.1089/neu.2013.2895&rft_dat=%3Cproquest_cross%3E1544014809%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1467432267&rft_id=info:pmid/23796187&rfr_iscdi=true |