PTEN inhibition enhances neurite outgrowth in human embryonic stem cell-derived neuronal progenitor cells

ABSTRACT We investigated the role of PTEN (phosphatase and tensin homolog deleted on chromosome 10) during neurite outgrowth of human embryonic stem cell (hESC)‐derived neuronal progenitors. PTEN inhibits phosphoinositide 3‐kinase (PI3K)/Akt signaling, a common and central outgrowth and survival pat...

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Veröffentlicht in:	Journal of comparative neurology (1911) 2014-08, Vol.522 (12), p.2741-2755
Hauptverfasser:	Wyatt, Lindsey A., Filbin, Marie T., Keirstead, Hans S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals axon Cell Differentiation - drug effects Cell Differentiation - physiology central nervous system CHO Cells Coculture Techniques Cricetulus - physiology Cyclic AMP - analogs & derivatives Cyclic AMP - metabolism Cyclic AMP - pharmacology Dose-Response Relationship, Drug Embryonic Stem Cells - drug effects Enzyme Inhibitors - pharmacology Humans Nerve Tissue Proteins - metabolism Neurites - drug effects Neurites - metabolism neuron Neurons - cytology Neurons - drug effects neuroregeneration Organometallic Compounds - pharmacology PTEN PTEN Phosphohydrolase - antagonists & inhibitors PTEN Phosphohydrolase - metabolism Ribosomal Protein S6 - metabolism Stem Cells - drug effects Stem Cells - physiology Thionucleotides - pharmacology Time Factors TOR Serine-Threonine Kinases - metabolism
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