Molecular mechanisms of HPV induced carcinogenesis in head and neck
Abstract A growing subgroup of oropharyngeal cancers is initiated by infection with high-risk human papillomaviruses (HPVs). In parallel to mounting epidemiological evidence, solid experimental data support a causal association between HPV and a subset of oropharyngeal cancers. This Review summarize...
Gespeichert in:
| Veröffentlicht in: | Oral oncology 2014-05, Vol.50 (5), p.356-363 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 363 |
|---|---|
| container_issue | 5 |
| container_start_page | 356 |
| container_title | Oral oncology |
| container_volume | 50 |
| creator | Rampias, Theodoros Sasaki, Clarence Psyrri, Amanda |
| description | Abstract A growing subgroup of oropharyngeal cancers is initiated by infection with high-risk human papillomaviruses (HPVs). In parallel to mounting epidemiological evidence, solid experimental data support a causal association between HPV and a subset of oropharyngeal cancers. This Review summarizes the main events of the HPV life cycle, the functions of the viral oncoproteins, and the implications of HPV infection on their hosts, with an emphasis on carcinogenic mechanisms in oropharyngeal cancer. The demonstration that HPVs have a role in head and neck carcinogenesis has fuelled the expectation that HPV-targeted therapeutic strategies may prove curative in these cancers. |
| doi_str_mv | 10.1016/j.oraloncology.2013.07.011 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1544014066</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1368837513006428</els_id><sourcerecordid>1544014066</sourcerecordid><originalsourceid>FETCH-LOGICAL-c468t-8663746e869b78e40e2d1282cbac9c02f01ea5df9637ad3344a7930fecc0e5e83</originalsourceid><addsrcrecordid>eNqNkU9v1DAQxS0EomXhK6CIE5eEcezEDgcktBSKVAQSf66WdzxpvU3sYm8q7bevV1sQ6onTjEbvzdP8hrFXHBoOvH-zbWKyUwwYp3i5b1rgogHVAOeP2CnXaqihG8Tj0ote11qo7oQ9y3kLAB3v4Ck7acXQCaX6U7b-EifCZbKpmgmvbPB5zlUcq_Nvvyof3ILkKrQJfYiXFCj7XMbVFVlX2eCqQHj9nD0Z7ZTpxX1dsZ8fz36sz-uLr58-r99f1Ch7vat13wsle9L9sFGaJFDreKtb3FgcENoRONnOjUORWSeElFYNAkZCBOpIixV7fdx7k-LvhfLOzD4jTZMNFJdseCclcAklZ8XeHqWYYs6JRnOT_GzT3nAwB4hma_6FaA4QDShTIBbzy_ucZTOT-2v9Q60IPhwFVK699ZRMRk-hoPKJcGdc9P-X8-7BGpx88Gina9pT3sYlhcLTcJNbA-b74Z2Hb3IB0MtWizvGgp5o</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1544014066</pqid></control><display><type>article</type><title>Molecular mechanisms of HPV induced carcinogenesis in head and neck</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Rampias, Theodoros ; Sasaki, Clarence ; Psyrri, Amanda</creator><creatorcontrib>Rampias, Theodoros ; Sasaki, Clarence ; Psyrri, Amanda</creatorcontrib><description>Abstract A growing subgroup of oropharyngeal cancers is initiated by infection with high-risk human papillomaviruses (HPVs). In parallel to mounting epidemiological evidence, solid experimental data support a causal association between HPV and a subset of oropharyngeal cancers. This Review summarizes the main events of the HPV life cycle, the functions of the viral oncoproteins, and the implications of HPV infection on their hosts, with an emphasis on carcinogenic mechanisms in oropharyngeal cancer. The demonstration that HPVs have a role in head and neck carcinogenesis has fuelled the expectation that HPV-targeted therapeutic strategies may prove curative in these cancers.</description><identifier>ISSN: 1368-8375</identifier><identifier>EISSN: 1879-0593</identifier><identifier>DOI: 10.1016/j.oraloncology.2013.07.011</identifier><identifier>PMID: 23953776</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Genome, Viral ; Head and Neck Neoplasms - virology ; Hematology, Oncology and Palliative Medicine ; HPV ; Human papillomavirus ; Humans ; Notch ; Oropharynx cancer ; Otolaryngology ; Papillomaviridae - genetics ; Papillomaviridae - isolation & purification ; Papillomaviridae - pathogenicity ; Tumor suppressor pathways ; Wnt</subject><ispartof>Oral oncology, 2014-05, Vol.50 (5), p.356-363</ispartof><rights>Elsevier Ltd</rights><rights>2013 Elsevier Ltd</rights><rights>Copyright © 2013 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c468t-8663746e869b78e40e2d1282cbac9c02f01ea5df9637ad3344a7930fecc0e5e83</citedby><cites>FETCH-LOGICAL-c468t-8663746e869b78e40e2d1282cbac9c02f01ea5df9637ad3344a7930fecc0e5e83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1368837513006428$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23953776$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rampias, Theodoros</creatorcontrib><creatorcontrib>Sasaki, Clarence</creatorcontrib><creatorcontrib>Psyrri, Amanda</creatorcontrib><title>Molecular mechanisms of HPV induced carcinogenesis in head and neck</title><title>Oral oncology</title><addtitle>Oral Oncol</addtitle><description>Abstract A growing subgroup of oropharyngeal cancers is initiated by infection with high-risk human papillomaviruses (HPVs). In parallel to mounting epidemiological evidence, solid experimental data support a causal association between HPV and a subset of oropharyngeal cancers. This Review summarizes the main events of the HPV life cycle, the functions of the viral oncoproteins, and the implications of HPV infection on their hosts, with an emphasis on carcinogenic mechanisms in oropharyngeal cancer. The demonstration that HPVs have a role in head and neck carcinogenesis has fuelled the expectation that HPV-targeted therapeutic strategies may prove curative in these cancers.</description><subject>Genome, Viral</subject><subject>Head and Neck Neoplasms - virology</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>HPV</subject><subject>Human papillomavirus</subject><subject>Humans</subject><subject>Notch</subject><subject>Oropharynx cancer</subject><subject>Otolaryngology</subject><subject>Papillomaviridae - genetics</subject><subject>Papillomaviridae - isolation & purification</subject><subject>Papillomaviridae - pathogenicity</subject><subject>Tumor suppressor pathways</subject><subject>Wnt</subject><issn>1368-8375</issn><issn>1879-0593</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9v1DAQxS0EomXhK6CIE5eEcezEDgcktBSKVAQSf66WdzxpvU3sYm8q7bevV1sQ6onTjEbvzdP8hrFXHBoOvH-zbWKyUwwYp3i5b1rgogHVAOeP2CnXaqihG8Tj0ote11qo7oQ9y3kLAB3v4Ck7acXQCaX6U7b-EifCZbKpmgmvbPB5zlUcq_Nvvyof3ILkKrQJfYiXFCj7XMbVFVlX2eCqQHj9nD0Z7ZTpxX1dsZ8fz36sz-uLr58-r99f1Ch7vat13wsle9L9sFGaJFDreKtb3FgcENoRONnOjUORWSeElFYNAkZCBOpIixV7fdx7k-LvhfLOzD4jTZMNFJdseCclcAklZ8XeHqWYYs6JRnOT_GzT3nAwB4hma_6FaA4QDShTIBbzy_ucZTOT-2v9Q60IPhwFVK699ZRMRk-hoPKJcGdc9P-X8-7BGpx88Gina9pT3sYlhcLTcJNbA-b74Z2Hb3IB0MtWizvGgp5o</recordid><startdate>20140501</startdate><enddate>20140501</enddate><creator>Rampias, Theodoros</creator><creator>Sasaki, Clarence</creator><creator>Psyrri, Amanda</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>20140501</creationdate><title>Molecular mechanisms of HPV induced carcinogenesis in head and neck</title><author>Rampias, Theodoros ; Sasaki, Clarence ; Psyrri, Amanda</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-8663746e869b78e40e2d1282cbac9c02f01ea5df9637ad3344a7930fecc0e5e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Genome, Viral</topic><topic>Head and Neck Neoplasms - virology</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>HPV</topic><topic>Human papillomavirus</topic><topic>Humans</topic><topic>Notch</topic><topic>Oropharynx cancer</topic><topic>Otolaryngology</topic><topic>Papillomaviridae - genetics</topic><topic>Papillomaviridae - isolation & purification</topic><topic>Papillomaviridae - pathogenicity</topic><topic>Tumor suppressor pathways</topic><topic>Wnt</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rampias, Theodoros</creatorcontrib><creatorcontrib>Sasaki, Clarence</creatorcontrib><creatorcontrib>Psyrri, Amanda</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Oral oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rampias, Theodoros</au><au>Sasaki, Clarence</au><au>Psyrri, Amanda</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular mechanisms of HPV induced carcinogenesis in head and neck</atitle><jtitle>Oral oncology</jtitle><addtitle>Oral Oncol</addtitle><date>2014-05-01</date><risdate>2014</risdate><volume>50</volume><issue>5</issue><spage>356</spage><epage>363</epage><pages>356-363</pages><issn>1368-8375</issn><eissn>1879-0593</eissn><abstract>Abstract A growing subgroup of oropharyngeal cancers is initiated by infection with high-risk human papillomaviruses (HPVs). In parallel to mounting epidemiological evidence, solid experimental data support a causal association between HPV and a subset of oropharyngeal cancers. This Review summarizes the main events of the HPV life cycle, the functions of the viral oncoproteins, and the implications of HPV infection on their hosts, with an emphasis on carcinogenic mechanisms in oropharyngeal cancer. The demonstration that HPVs have a role in head and neck carcinogenesis has fuelled the expectation that HPV-targeted therapeutic strategies may prove curative in these cancers.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>23953776</pmid><doi>10.1016/j.oraloncology.2013.07.011</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1368-8375 |
| ispartof | Oral oncology, 2014-05, Vol.50 (5), p.356-363 |
| issn | 1368-8375 1879-0593 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1544014066 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Genome, Viral Head and Neck Neoplasms - virology Hematology, Oncology and Palliative Medicine HPV Human papillomavirus Humans Notch Oropharynx cancer Otolaryngology Papillomaviridae - genetics Papillomaviridae - isolation & purification Papillomaviridae - pathogenicity Tumor suppressor pathways Wnt |
| title | Molecular mechanisms of HPV induced carcinogenesis in head and neck |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T22%3A09%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Molecular%20mechanisms%20of%20HPV%20induced%20carcinogenesis%20in%20head%20and%20neck&rft.jtitle=Oral%20oncology&rft.au=Rampias,%20Theodoros&rft.date=2014-05-01&rft.volume=50&rft.issue=5&rft.spage=356&rft.epage=363&rft.pages=356-363&rft.issn=1368-8375&rft.eissn=1879-0593&rft_id=info:doi/10.1016/j.oraloncology.2013.07.011&rft_dat=%3Cproquest_cross%3E1544014066%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1544014066&rft_id=info:pmid/23953776&rft_els_id=S1368837513006428&rfr_iscdi=true |