Development of biodegradable in situ implant and microparticle injectable formulations for sustained delivery of haloperidol

The objective of this study is to formulate injectable, biodegradable sustained release in situ implant (ISI), and in situ microparticle (ISM) formulations of haloperidol. Factors affecting the in vitro drug release, pharmacokinetics, and stability of the formulations were investigated. The concentr...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2012-10, Vol.101 (10), p.3753-3762
Hauptverfasser:	Ahmed, Tarek A., Ibrahim, Hany M., Ibrahim, Fathy, Samy, Ahmed M., Kaseem, Alaa, H. Nutan, Mohammad T., Hussain, Muhammad Delwar
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorbable Implants Animals biodegradable polymers Biological and medical sciences Chemistry, Pharmaceutical - methods Delayed-Action Preparations Drug Delivery Systems - methods Drug Stability General pharmacology haloperidol Haloperidol - administration & dosage Haloperidol - chemistry Haloperidol - pharmacokinetics in situ implants in situ microparticles injectables Injections - methods Lactic Acid - administration & dosage Lactic Acid - chemistry Male Medical sciences Molecular Weight Pharmaceutical technology. Pharmaceutical industry pharmacokinetics Pharmacology. Drug treatments PLGA Polyglycolic Acid - administration & dosage Polyglycolic Acid - chemistry Polymers - administration & dosage Polymers - chemistry Rats Rats, Sprague-Dawley Solvents - chemistry stability sustained release
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