Synthesis, insecticidal, and fungicidal screening of some new quinoline derivatives

This paper describes the synthesis of a series of quinolines graphted with hydrazones, pyrazoles, pyridazine, phthalazine, triazepinone, semicarbazide, and thiomorpholide moieties and four metal complexes. These derivatives were screened against Fusarium oxysporum and the red palm weevil (RPW) Rhync...

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Veröffentlicht in:Russian journal of bioorganic chemistry 2014-03, Vol.40 (2), p.214-227
Hauptverfasser: Aly, M. R. E., Ibrahim, M. M., Okael, A. M., Gherbawy, Y. A. M. H.
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container_title Russian journal of bioorganic chemistry
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creator Aly, M. R. E.
Ibrahim, M. M.
Okael, A. M.
Gherbawy, Y. A. M. H.
description This paper describes the synthesis of a series of quinolines graphted with hydrazones, pyrazoles, pyridazine, phthalazine, triazepinone, semicarbazide, and thiomorpholide moieties and four metal complexes. These derivatives were screened against Fusarium oxysporum and the red palm weevil (RPW) Rhynchophorus ferrugineus Oliver (coleopteran: Curculionidae) as palm pathogens. Only chlorinated quinolines were active against these organisms with hydrazones being good fungicides, while those modified with pyrazoles and pyrazines showed moderate insecticidal activity. A unique trihydroxylated hydrazone was active against both organisms, while another hydrazone, the most potent fungicide in this series, exhibited insecticidal activity only upon complexation with Zn 2+ ions.
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subjects Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Curculionidae
Fusarium oxysporum
Life Sciences
Organic Chemistry
Rhynchophorus ferrugineus
title Synthesis, insecticidal, and fungicidal screening of some new quinoline derivatives
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