Mechanistic Studies Unravel the Complexity Inherent in Tau Aggregation Leading to Alzheimer’s Disease and the Tauopathies

The aggregation of the protein tau into amyloid fibrils is known to be involved in the causation of the neurodegenerative tauopathies and the progression of cognitive decline in Alzheimer’s disease. This review surveys the mechanism of tau aggregation with special emphasis on the information obtaine...

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Veröffentlicht in:	Biochemistry (Easton) 2013-06, Vol.52 (24), p.4107-4126
Hauptverfasser:	Ramachandran, Gayathri, Udgaonkar, Jayant B
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Amyloid - metabolism Amyloidogenic Proteins - chemistry Animals Brain - metabolism DNA - chemistry Humans Kinetics Mutation Neurodegenerative Diseases - drug therapy Neurofibrillary Tangles - metabolism Phosphorylation Protein Binding Protein Conformation Structure-Activity Relationship tau Proteins - chemistry Tauopathies - metabolism Time Factors
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