Neuroprotective and antioxidant effects of curcumin in a ketamine-induced model of mania in rats

Bipolar disorder (BD) is a chronic and debilitating illness characterized by recurrent manic and depressive episodes. Our research investigates the protective effects of curcumin, the main curcuminoid of the Indian spice turmeric, in a model of mania induced by ketamine administration in rats. Our r...

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Veröffentlicht in:	European journal of pharmacology 2014-02, Vol.724, p.132-139
Hauptverfasser:	Gazal, Marta, Valente, Matheus R., Acosta, Bruna A., Kaufmann, Fernanda N., Braganhol, Elizandra, Lencina, Claiton L., Stefanello, Francieli M., Ghisleni, Gabriele, Kaster, Manuella P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimanic Agents - pharmacology Antimanic Agents - therapeutic use Antioxidant Antioxidants - pharmacology Antioxidants - therapeutic use Behavior, Animal - drug effects Bipolar Disorder - chemically induced Bipolar Disorder - drug therapy Bipolar Disorder - metabolism Catalase - metabolism Curcuma longa Curcumin Curcumin - pharmacology Curcumin - therapeutic use Female Hippocampus - drug effects Hippocampus - metabolism Ketamine Mania Motor Activity - drug effects Neuroprotective Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Oxidative Stress - drug effects Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism Rats Rats, Wistar Superoxide Dismutase - metabolism Thiobarbituric Acid Reactive Substances - metabolism
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