Inner retinal layer comparisons of eyes with exudative age-related macular degeneration and eyes with age-related macular degeneration and glaucoma
Background The incidence of glaucoma increases with age, as does age-related macular degeneration (AMD), with the reported incidence of glaucoma among AMD subjects being 5.4 %. Optical coherence tomography (OCT) can detect glaucomatous changes in the inner retina with high sensitivity. The purpose o...
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| Veröffentlicht in: | Graefe's archive for clinical and experimental ophthalmology 2014-04, Vol.252 (4), p.563-570 |
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| creator | Rimayanti, Ulfah Kiuchi, Yoshiaki Yamane, Ken Latief, Miftahul Akhyar Mochizuki, Hideki Hirata, Junko Akita, Tomoyuki Tanaka, Junko |
| description | Background
The incidence of glaucoma increases with age, as does age-related macular degeneration (AMD), with the reported incidence of glaucoma among AMD subjects being 5.4 %. Optical coherence tomography (OCT) can detect glaucomatous changes in the inner retina with high sensitivity. The purpose of this study was to compare ganglion cell complex (GCC) parameters and the thickness of the peripapillary retinal nerve fiber layer (RNFL) in normal eyes to that observed in eyes with age-related macular degeneration (AMD) and eyes with both AMD and glaucoma.
Methods
The GCC components [GCC thickness, focal loss volume (FLV), and global loss volume (GLV)] and peripapillary RNFL thickness were measured using RTVue spectral-domain OCT (SD-OCT). The GCC and RNFL parameters of normal eyes, AMD eyes treated with different types of therapy, and AMD eyes with and without glaucoma were evaluated using nonparametric tests. Univariate and multivariate analyses were used to determine whether the GCC and RNFL parameters could be used to differentiate AMD eyes with glaucoma from those without glaucoma.
Results
Seventy-one normal eyes, 120 eyes with AMD, and 23 eyes with AMD and glaucoma were studied. The values of all GCC components were significantly different in the normal eyes from those observed in the eyes with AMD, except for the RNFL thicknesses. The GCC and RNFL parameters were not significantly different between the eyes receiving different types of therapy among the AMD groups. The RNFL thickness was significantly correlated with glaucoma diagnosis in AMD eyes.
Conclusions
These findings indicate that there is damage to the inner retinal layers in eyes with AMD. The RNFL thickness can be a useful parameter for differentiating eyes with AMD from eyes with both AMD and glaucoma. |
| doi_str_mv | 10.1007/s00417-013-2496-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1544008343</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1544008343</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-d78e73f33e03d4a565f71c801e8185018519b93ce8450aada220afd5152e8bde3</originalsourceid><addsrcrecordid>eNqNkcuKFDEUhoMoTjv6AG4k4MZN9JxcOlVLGbwMDLhRmF04XTnV1lCXNqly7HkNX9i0PcogCLMIIeT7_wPnE-I5wmsE8G8ygEWvAI3Stl6rmwdihdY45UFfPhQr8BpVZfTliXiS8xUU3Dh8LE60RbvWXq_Ez_Nx5CQTz91IvexpX17NNOwodXkas5xayXvO8rqbv0r-sUSau-8sacsqcU8zRzlQs_SUZOQtl7ICTKOkMd4J3gvf9rSU0fRUPGqpz_zs9j4VX96_-3z2UV18-nB-9vZCNRbcrKKv2JvWGAYTLbm1az02FSBXWDkoB-tNbRqurAOiSFoDtdGh01xtIptT8erYu0vTt4XzHIYuN9z3NPK05IDOWoDKWHMPFNHU2tUH9OU_6NW0pLLc3xR4U3tfFwqPVJOmnBO3YZe6gdI-IISD3HCUG4rccJAbbkrmxW3zshk4_k38sVkAfQRy-Rq3nO6M_m_rL-o9saQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1510739779</pqid></control><display><type>article</type><title>Inner retinal layer comparisons of eyes with exudative age-related macular degeneration and eyes with age-related macular degeneration and glaucoma</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Rimayanti, Ulfah ; Kiuchi, Yoshiaki ; Yamane, Ken ; Latief, Miftahul Akhyar ; Mochizuki, Hideki ; Hirata, Junko ; Akita, Tomoyuki ; Tanaka, Junko</creator><creatorcontrib>Rimayanti, Ulfah ; Kiuchi, Yoshiaki ; Yamane, Ken ; Latief, Miftahul Akhyar ; Mochizuki, Hideki ; Hirata, Junko ; Akita, Tomoyuki ; Tanaka, Junko</creatorcontrib><description>Background
The incidence of glaucoma increases with age, as does age-related macular degeneration (AMD), with the reported incidence of glaucoma among AMD subjects being 5.4 %. Optical coherence tomography (OCT) can detect glaucomatous changes in the inner retina with high sensitivity. The purpose of this study was to compare ganglion cell complex (GCC) parameters and the thickness of the peripapillary retinal nerve fiber layer (RNFL) in normal eyes to that observed in eyes with age-related macular degeneration (AMD) and eyes with both AMD and glaucoma.
Methods
The GCC components [GCC thickness, focal loss volume (FLV), and global loss volume (GLV)] and peripapillary RNFL thickness were measured using RTVue spectral-domain OCT (SD-OCT). The GCC and RNFL parameters of normal eyes, AMD eyes treated with different types of therapy, and AMD eyes with and without glaucoma were evaluated using nonparametric tests. Univariate and multivariate analyses were used to determine whether the GCC and RNFL parameters could be used to differentiate AMD eyes with glaucoma from those without glaucoma.
Results
Seventy-one normal eyes, 120 eyes with AMD, and 23 eyes with AMD and glaucoma were studied. The values of all GCC components were significantly different in the normal eyes from those observed in the eyes with AMD, except for the RNFL thicknesses. The GCC and RNFL parameters were not significantly different between the eyes receiving different types of therapy among the AMD groups. The RNFL thickness was significantly correlated with glaucoma diagnosis in AMD eyes.
Conclusions
These findings indicate that there is damage to the inner retinal layers in eyes with AMD. The RNFL thickness can be a useful parameter for differentiating eyes with AMD from eyes with both AMD and glaucoma.</description><identifier>ISSN: 0721-832X</identifier><identifier>EISSN: 1435-702X</identifier><identifier>DOI: 10.1007/s00417-013-2496-z</identifier><identifier>PMID: 24146272</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aged ; Angiogenesis Inhibitors - therapeutic use ; Exudates and Transudates ; Female ; Fluorescein Angiography ; Glaucoma ; Glaucoma - diagnosis ; Humans ; Intraocular Pressure ; Macular degeneration ; Male ; Medicine ; Medicine & Public Health ; Nerve Fibers - pathology ; Ophthalmology ; Photochemotherapy ; Retinal Disorders ; Retinal Ganglion Cells - pathology ; Tomography, Optical Coherence ; Tonometry, Ocular ; Visual Acuity - physiology ; Wet Macular Degeneration - diagnosis ; Wet Macular Degeneration - drug therapy</subject><ispartof>Graefe's archive for clinical and experimental ophthalmology, 2014-04, Vol.252 (4), p.563-570</ispartof><rights>Springer-Verlag Berlin Heidelberg 2013</rights><rights>Springer-Verlag Berlin Heidelberg 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-d78e73f33e03d4a565f71c801e8185018519b93ce8450aada220afd5152e8bde3</citedby><cites>FETCH-LOGICAL-c405t-d78e73f33e03d4a565f71c801e8185018519b93ce8450aada220afd5152e8bde3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00417-013-2496-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00417-013-2496-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24146272$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rimayanti, Ulfah</creatorcontrib><creatorcontrib>Kiuchi, Yoshiaki</creatorcontrib><creatorcontrib>Yamane, Ken</creatorcontrib><creatorcontrib>Latief, Miftahul Akhyar</creatorcontrib><creatorcontrib>Mochizuki, Hideki</creatorcontrib><creatorcontrib>Hirata, Junko</creatorcontrib><creatorcontrib>Akita, Tomoyuki</creatorcontrib><creatorcontrib>Tanaka, Junko</creatorcontrib><title>Inner retinal layer comparisons of eyes with exudative age-related macular degeneration and eyes with age-related macular degeneration and glaucoma</title><title>Graefe's archive for clinical and experimental ophthalmology</title><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><description>Background
The incidence of glaucoma increases with age, as does age-related macular degeneration (AMD), with the reported incidence of glaucoma among AMD subjects being 5.4 %. Optical coherence tomography (OCT) can detect glaucomatous changes in the inner retina with high sensitivity. The purpose of this study was to compare ganglion cell complex (GCC) parameters and the thickness of the peripapillary retinal nerve fiber layer (RNFL) in normal eyes to that observed in eyes with age-related macular degeneration (AMD) and eyes with both AMD and glaucoma.
Methods
The GCC components [GCC thickness, focal loss volume (FLV), and global loss volume (GLV)] and peripapillary RNFL thickness were measured using RTVue spectral-domain OCT (SD-OCT). The GCC and RNFL parameters of normal eyes, AMD eyes treated with different types of therapy, and AMD eyes with and without glaucoma were evaluated using nonparametric tests. Univariate and multivariate analyses were used to determine whether the GCC and RNFL parameters could be used to differentiate AMD eyes with glaucoma from those without glaucoma.
Results
Seventy-one normal eyes, 120 eyes with AMD, and 23 eyes with AMD and glaucoma were studied. The values of all GCC components were significantly different in the normal eyes from those observed in the eyes with AMD, except for the RNFL thicknesses. The GCC and RNFL parameters were not significantly different between the eyes receiving different types of therapy among the AMD groups. The RNFL thickness was significantly correlated with glaucoma diagnosis in AMD eyes.
Conclusions
These findings indicate that there is damage to the inner retinal layers in eyes with AMD. The RNFL thickness can be a useful parameter for differentiating eyes with AMD from eyes with both AMD and glaucoma.</description><subject>Aged</subject><subject>Angiogenesis Inhibitors - therapeutic use</subject><subject>Exudates and Transudates</subject><subject>Female</subject><subject>Fluorescein Angiography</subject><subject>Glaucoma</subject><subject>Glaucoma - diagnosis</subject><subject>Humans</subject><subject>Intraocular Pressure</subject><subject>Macular degeneration</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nerve Fibers - pathology</subject><subject>Ophthalmology</subject><subject>Photochemotherapy</subject><subject>Retinal Disorders</subject><subject>Retinal Ganglion Cells - pathology</subject><subject>Tomography, Optical Coherence</subject><subject>Tonometry, Ocular</subject><subject>Visual Acuity - physiology</subject><subject>Wet Macular Degeneration - diagnosis</subject><subject>Wet Macular Degeneration - drug therapy</subject><issn>0721-832X</issn><issn>1435-702X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkcuKFDEUhoMoTjv6AG4k4MZN9JxcOlVLGbwMDLhRmF04XTnV1lCXNqly7HkNX9i0PcogCLMIIeT7_wPnE-I5wmsE8G8ygEWvAI3Stl6rmwdihdY45UFfPhQr8BpVZfTliXiS8xUU3Dh8LE60RbvWXq_Ez_Nx5CQTz91IvexpX17NNOwodXkas5xayXvO8rqbv0r-sUSau-8sacsqcU8zRzlQs_SUZOQtl7ICTKOkMd4J3gvf9rSU0fRUPGqpz_zs9j4VX96_-3z2UV18-nB-9vZCNRbcrKKv2JvWGAYTLbm1az02FSBXWDkoB-tNbRqurAOiSFoDtdGh01xtIptT8erYu0vTt4XzHIYuN9z3NPK05IDOWoDKWHMPFNHU2tUH9OU_6NW0pLLc3xR4U3tfFwqPVJOmnBO3YZe6gdI-IISD3HCUG4rccJAbbkrmxW3zshk4_k38sVkAfQRy-Rq3nO6M_m_rL-o9saQ</recordid><startdate>20140401</startdate><enddate>20140401</enddate><creator>Rimayanti, Ulfah</creator><creator>Kiuchi, Yoshiaki</creator><creator>Yamane, Ken</creator><creator>Latief, Miftahul Akhyar</creator><creator>Mochizuki, Hideki</creator><creator>Hirata, Junko</creator><creator>Akita, Tomoyuki</creator><creator>Tanaka, Junko</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20140401</creationdate><title>Inner retinal layer comparisons of eyes with exudative age-related macular degeneration and eyes with age-related macular degeneration and glaucoma</title><author>Rimayanti, Ulfah ; Kiuchi, Yoshiaki ; Yamane, Ken ; Latief, Miftahul Akhyar ; Mochizuki, Hideki ; Hirata, Junko ; Akita, Tomoyuki ; Tanaka, Junko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-d78e73f33e03d4a565f71c801e8185018519b93ce8450aada220afd5152e8bde3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Angiogenesis Inhibitors - therapeutic use</topic><topic>Exudates and Transudates</topic><topic>Female</topic><topic>Fluorescein Angiography</topic><topic>Glaucoma</topic><topic>Glaucoma - diagnosis</topic><topic>Humans</topic><topic>Intraocular Pressure</topic><topic>Macular degeneration</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nerve Fibers - pathology</topic><topic>Ophthalmology</topic><topic>Photochemotherapy</topic><topic>Retinal Disorders</topic><topic>Retinal Ganglion Cells - pathology</topic><topic>Tomography, Optical Coherence</topic><topic>Tonometry, Ocular</topic><topic>Visual Acuity - physiology</topic><topic>Wet Macular Degeneration - diagnosis</topic><topic>Wet Macular Degeneration - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rimayanti, Ulfah</creatorcontrib><creatorcontrib>Kiuchi, Yoshiaki</creatorcontrib><creatorcontrib>Yamane, Ken</creatorcontrib><creatorcontrib>Latief, Miftahul Akhyar</creatorcontrib><creatorcontrib>Mochizuki, Hideki</creatorcontrib><creatorcontrib>Hirata, Junko</creatorcontrib><creatorcontrib>Akita, Tomoyuki</creatorcontrib><creatorcontrib>Tanaka, Junko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rimayanti, Ulfah</au><au>Kiuchi, Yoshiaki</au><au>Yamane, Ken</au><au>Latief, Miftahul Akhyar</au><au>Mochizuki, Hideki</au><au>Hirata, Junko</au><au>Akita, Tomoyuki</au><au>Tanaka, Junko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inner retinal layer comparisons of eyes with exudative age-related macular degeneration and eyes with age-related macular degeneration and glaucoma</atitle><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle><stitle>Graefes Arch Clin Exp Ophthalmol</stitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><date>2014-04-01</date><risdate>2014</risdate><volume>252</volume><issue>4</issue><spage>563</spage><epage>570</epage><pages>563-570</pages><issn>0721-832X</issn><eissn>1435-702X</eissn><abstract>Background
The incidence of glaucoma increases with age, as does age-related macular degeneration (AMD), with the reported incidence of glaucoma among AMD subjects being 5.4 %. Optical coherence tomography (OCT) can detect glaucomatous changes in the inner retina with high sensitivity. The purpose of this study was to compare ganglion cell complex (GCC) parameters and the thickness of the peripapillary retinal nerve fiber layer (RNFL) in normal eyes to that observed in eyes with age-related macular degeneration (AMD) and eyes with both AMD and glaucoma.
Methods
The GCC components [GCC thickness, focal loss volume (FLV), and global loss volume (GLV)] and peripapillary RNFL thickness were measured using RTVue spectral-domain OCT (SD-OCT). The GCC and RNFL parameters of normal eyes, AMD eyes treated with different types of therapy, and AMD eyes with and without glaucoma were evaluated using nonparametric tests. Univariate and multivariate analyses were used to determine whether the GCC and RNFL parameters could be used to differentiate AMD eyes with glaucoma from those without glaucoma.
Results
Seventy-one normal eyes, 120 eyes with AMD, and 23 eyes with AMD and glaucoma were studied. The values of all GCC components were significantly different in the normal eyes from those observed in the eyes with AMD, except for the RNFL thicknesses. The GCC and RNFL parameters were not significantly different between the eyes receiving different types of therapy among the AMD groups. The RNFL thickness was significantly correlated with glaucoma diagnosis in AMD eyes.
Conclusions
These findings indicate that there is damage to the inner retinal layers in eyes with AMD. The RNFL thickness can be a useful parameter for differentiating eyes with AMD from eyes with both AMD and glaucoma.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>24146272</pmid><doi>10.1007/s00417-013-2496-z</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0721-832X |
| ispartof | Graefe's archive for clinical and experimental ophthalmology, 2014-04, Vol.252 (4), p.563-570 |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Aged Angiogenesis Inhibitors - therapeutic use Exudates and Transudates Female Fluorescein Angiography Glaucoma Glaucoma - diagnosis Humans Intraocular Pressure Macular degeneration Male Medicine Medicine & Public Health Nerve Fibers - pathology Ophthalmology Photochemotherapy Retinal Disorders Retinal Ganglion Cells - pathology Tomography, Optical Coherence Tonometry, Ocular Visual Acuity - physiology Wet Macular Degeneration - diagnosis Wet Macular Degeneration - drug therapy |
| title | Inner retinal layer comparisons of eyes with exudative age-related macular degeneration and eyes with age-related macular degeneration and glaucoma |
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