trans-Caryophyllene is a natural agonistic ligand for peroxisome proliferator-activated receptor-α

Intake of dietary aroma compounds may regulate cellular lipid metabolism. We demonstrated that trans-caryophyllene, a flavor compound in plant foods and teas, activates peroxisome proliferator-activated receptor (PPAR)-α through direct interaction with the ligand-binding domain of PPAR-α. The agonis...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2014-07, Vol.24 (14), p.3168-3174
Hauptverfasser:	Wu, Chunyan, Jia, Yaoyao, Lee, Ji Hae, Jun, Hee-jin, Lee, Hae-Seung, Hwang, Kwang-Yeon, Lee, Sung-Joon
Format:	Artikel
Sprache:	eng
Schlagworte:	Dose-Response Relationship, Drug Hepatocyte Humans Ligands Lipid metabolism Models, Molecular Molecular Conformation PPAR alpha - agonists PPAR-α Sesquiterpenes - chemistry Sesquiterpenes - pharmacology Stereoisomerism Structure-Activity Relationship trans-Caryophyllene
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