An Evolutionarily Conserved Mechanism of Calcium-Dependent Neurotoxicity in a Zebrafish Model of Fetal Alcohol Spectrum Disorders

Background Fetal alcohol spectrum disorders (FASD) are a leading cause of neurodevelopmental disability. Nonhuman animal models offer novel insights into its underlying mechanisms. Although the developing zebrafish has great promise for FASD research, a significant challenge to its wider adoption is...

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Veröffentlicht in:	Alcoholism, clinical and experimental research clinical and experimental research, 2014-05, Vol.38 (5), p.1255-1265
Hauptverfasser:	Flentke, George R., Klingler, Rebekah H., Tanguay, Robert L., Carvan III, Michael J., Smith, Susan M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amniota Animals Apoptosis Apoptosis - drug effects Calcium Signaling Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism Danio rerio Disease Models, Animal Dose-Response Relationship, Drug Enzyme Activation - drug effects Ethanol Ethanol - pharmacology Fetal Alcohol Spectrum Disorders Fetal Alcohol Spectrum Disorders - etiology In Situ Nick-End Labeling Neural Crest Neural Crest - drug effects Neural Crest - embryology Neurogenesis - drug effects Neurotoxicity Syndromes - embryology Neurotoxicity Syndromes - etiology Teleostei Zebrafish
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