Thiazolidine-2,4-diones derivatives as PPAR-γ agonists: Synthesis, molecular docking, in vitro and in vivo antidiabetic activity with hepatotoxicity risk evaluation and effect on PPAR-γ gene expression

A library of 2,4-thiazolidinedione analogues have been synthesized which exhibited potent in vitro PPAR-γ and in vivo antidiabetic activity without causing any toxicity to liver. A library of conjugates of chromones and 2,4-thiazolidinedione has been synthesized by Knoevenagel condensation followed...

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