Amantadine improves cognitive outcome and increases neuronal survival after fluid percussion traumatic brain injury in rats

This study evaluated the effects of clinically relevant concentrations of amantadine (AMT) on cognitive outcome and hippocampal cell survival in adult rats after lateral fluid percussion traumatic brain injury (TBI). AMT is an antagonist of the N-methyl-D-aspartate-type glutamate receptor, increases...

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Veröffentlicht in:	Journal of neurotrauma 2014-02, Vol.31 (4), p.370-377
Hauptverfasser:	Wang, Tao, Huang, Xian-Jian, Van, Ken C, Went, Gregory T, Nguyen, Jack T, Lyeth, Bruce G
Format:	Artikel
Sprache:	eng
Schlagworte:	Amantadine - pharmacokinetics Amantadine - therapeutic use Analysis of Variance Animal cognition Animals Body Weight - drug effects Brain damage Brain Injuries - drug therapy Brain Injuries - psychology CA2 Region, Hippocampal - pathology CA3 Region, Hippocampal - pathology Cell Count Cell Survival - drug effects Cognition - drug effects Dopamine Agents - pharmacokinetics Dopamine Agents - therapeutic use Dose-Response Relationship, Drug Drug therapy Learning - drug effects Male Maze Learning - drug effects Memory - drug effects Neurons Neurons - drug effects Pharmacology Rats Rats, Sprague-Dawley Rodents Trauma Treatment Outcome
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