Synthesis and biological evaluation of 68Ga-bis-DOTA-PA as a potential agent for positron emission tomography imaging of necrosis

Necrosis is a form of cell death that occurs in a variety of pathological conditions but can also be the result of therapy in cancer treatment. A radiotracer that could image necrotic cell death using PET could therefore be a useful tool to provide relevant information on the disease activity or the...

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Veröffentlicht in:	Nuclear medicine and biology 2013-08, Vol.40 (6), p.816-822
Hauptverfasser:	Prinsen, Kristof, Cona, Marlein M., Cleynhens, Bernard J., Li, Junjie, Vanbilloen, Hubert, Dyubankova, Natalia, Lescrinier, Eveline, Ni, Yicheng, Bormans, Guy M., Verbruggen, Alfons M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell death Chemistry Techniques, Synthetic Gallium Radioisotopes Gallium-68 Heterocyclic Compounds, 1-Ring - chemistry Heterocyclic Compounds, 1-Ring - pharmacokinetics Liver - diagnostic imaging Liver - pathology Male Mice Naphthols - chemistry Necrosis Necrosis - diagnostic imaging Pamoic acid PET Positron-Emission Tomography - methods Radiochemistry Rats
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