Chemical proteomics reveals HSP70 1A as a target for the anticancer diterpene oridonin in Jurkat cells

Oridonin, an ent-kaurane diterpene isolated from well known Chinese medicinal plant Isodon rubescens, has been shown to have multiple biological activities. Among them, the anticancer activity has been repeatedly reported by many research groups. The chemopreventive and antitumor effects of oridonin...

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Veröffentlicht in:	Journal of proteomics 2013-04, Vol.82, p.14-26
Hauptverfasser:	Dal Piaz, Fabrizio, Cotugno, Roberta, Lepore, Laura, Vassallo, Antonio, Malafronte, Nicola, Lauro, Gianluigi, Bifulco, Giuseppe, Belisario, Maria Antonietta, De Tommasi, Nunziatina
Format:	Artikel
Sprache:	eng
Schlagworte:	adverse effects anticarcinogenic activity Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology apoptosis autophagy binding sites cell cycle cell proliferation Chemical proteomics chemoprevention clinical trials Diterpenes, Kaurane - chemistry Diterpenes, Kaurane - pharmacology drugs heat-shock protein 70 HSP70 1A HSP70 Heat-Shock Proteins - antagonists & inhibitors HSP70 Heat-Shock Proteins - chemistry HSP70 Heat-Shock Proteins - genetics HSP70 Heat-Shock Proteins - metabolism Humans Jurkat Cells Leukemia - drug therapy Leukemia - metabolism mechanism of action medicinal plants molecular dynamics Molecular Dynamics Simulation Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - chemistry Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Oridonin patients Proteomics survival rate Target discovery
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