Evaluation of brain iron content in idiopathic REM sleep behavior disorder using quantitative magnetic resonance imaging
Abstract Background Neuroimaging studies in patients with idiopathic rapid eye movement sleep behavior disorder (iRBD) show similar structural and functional changes to alpha-synucleinopathies, including PD. Until now, there have been few attempts to characterize brain iron deposition in iRBD. The a...
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| Veröffentlicht in: | Parkinsonism & related disorders 2014-07, Vol.20 (7), p.776-778 |
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| creator | Lee, Jae-Hyeok Han, Yong-Hee Cho, Jae-Wook Lee, Jin-Seong Lee, Sang-Jae Kim, Dae-Jin Kim, Tae-Hyoung Kang, Bok-Man Kim, Tae-Hyung Mun, Chi-Woong |
| description | Abstract Background Neuroimaging studies in patients with idiopathic rapid eye movement sleep behavior disorder (iRBD) show similar structural and functional changes to alpha-synucleinopathies, including PD. Until now, there have been few attempts to characterize brain iron deposition in iRBD. The aim of this study was to investigate brain iron content in patients with iRBD using quantitative magnetic resonance imaging (MRI). Methods 3-T MRI was performed in 15 patients with iRBD and 20 age-matched healthy control subjects. In order to evaluate the iron-related neurodegenerative changes, we assessed volume and transverse relaxation rate (R2*) simultaneously. We used both region-based and voxel-based analysis. Results No significant differences in R2* values were found between iRBD groups and healthy control subjects. There were no areas of significantly reduced or increased gray matter and white matter volume in the iRBD group. Instead, lateral ventricle volumes measured automatically by FreeSurfer were significantly larger in patients with iRBD than in healthy controls ( P |
| doi_str_mv | 10.1016/j.parkreldis.2014.03.023 |
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Until now, there have been few attempts to characterize brain iron deposition in iRBD. The aim of this study was to investigate brain iron content in patients with iRBD using quantitative magnetic resonance imaging (MRI). Methods 3-T MRI was performed in 15 patients with iRBD and 20 age-matched healthy control subjects. In order to evaluate the iron-related neurodegenerative changes, we assessed volume and transverse relaxation rate (R2*) simultaneously. We used both region-based and voxel-based analysis. Results No significant differences in R2* values were found between iRBD groups and healthy control subjects. There were no areas of significantly reduced or increased gray matter and white matter volume in the iRBD group. Instead, lateral ventricle volumes measured automatically by FreeSurfer were significantly larger in patients with iRBD than in healthy controls ( P < 0.05). Conclusion The present study suggests that iron-related R2* values may not be an imaging biomarker for neurodegeneration in iRBD.</description><identifier>ISSN: 1353-8020</identifier><identifier>EISSN: 1873-5126</identifier><identifier>DOI: 10.1016/j.parkreldis.2014.03.023</identifier><identifier>PMID: 24731528</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Aged ; Biomarkers - metabolism ; Brain - metabolism ; Brain Chemistry - physiology ; Cross-Sectional Studies ; Female ; Humans ; Idiopathic REM sleep behavior disorder ; Iron ; Iron - analysis ; Iron - metabolism ; Magnetic Resonance Imaging - methods ; Male ; Middle Aged ; MRI ; Neurology ; Parkinson Disease - diagnosis ; Parkinson Disease - metabolism ; REM Sleep Behavior Disorder - diagnosis ; REM Sleep Behavior Disorder - metabolism ; Volume</subject><ispartof>Parkinsonism & related disorders, 2014-07, Vol.20 (7), p.776-778</ispartof><rights>Elsevier Ltd</rights><rights>2014 Elsevier Ltd</rights><rights>Copyright © 2014 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c462t-4229c4dfa70eb8571be0ab4e83163434b82139898e00976e10d574f74887ee2f3</citedby><cites>FETCH-LOGICAL-c462t-4229c4dfa70eb8571be0ab4e83163434b82139898e00976e10d574f74887ee2f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1353802014001333$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24731528$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Jae-Hyeok</creatorcontrib><creatorcontrib>Han, Yong-Hee</creatorcontrib><creatorcontrib>Cho, Jae-Wook</creatorcontrib><creatorcontrib>Lee, Jin-Seong</creatorcontrib><creatorcontrib>Lee, Sang-Jae</creatorcontrib><creatorcontrib>Kim, Dae-Jin</creatorcontrib><creatorcontrib>Kim, Tae-Hyoung</creatorcontrib><creatorcontrib>Kang, Bok-Man</creatorcontrib><creatorcontrib>Kim, Tae-Hyung</creatorcontrib><creatorcontrib>Mun, Chi-Woong</creatorcontrib><title>Evaluation of brain iron content in idiopathic REM sleep behavior disorder using quantitative magnetic resonance imaging</title><title>Parkinsonism & related disorders</title><addtitle>Parkinsonism Relat Disord</addtitle><description>Abstract Background Neuroimaging studies in patients with idiopathic rapid eye movement sleep behavior disorder (iRBD) show similar structural and functional changes to alpha-synucleinopathies, including PD. Until now, there have been few attempts to characterize brain iron deposition in iRBD. The aim of this study was to investigate brain iron content in patients with iRBD using quantitative magnetic resonance imaging (MRI). Methods 3-T MRI was performed in 15 patients with iRBD and 20 age-matched healthy control subjects. In order to evaluate the iron-related neurodegenerative changes, we assessed volume and transverse relaxation rate (R2*) simultaneously. We used both region-based and voxel-based analysis. Results No significant differences in R2* values were found between iRBD groups and healthy control subjects. There were no areas of significantly reduced or increased gray matter and white matter volume in the iRBD group. Instead, lateral ventricle volumes measured automatically by FreeSurfer were significantly larger in patients with iRBD than in healthy controls ( P < 0.05). Conclusion The present study suggests that iron-related R2* values may not be an imaging biomarker for neurodegeneration in iRBD.</description><subject>Aged</subject><subject>Biomarkers - metabolism</subject><subject>Brain - metabolism</subject><subject>Brain Chemistry - physiology</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Idiopathic REM sleep behavior disorder</subject><subject>Iron</subject><subject>Iron - analysis</subject><subject>Iron - metabolism</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>MRI</subject><subject>Neurology</subject><subject>Parkinson Disease - diagnosis</subject><subject>Parkinson Disease - metabolism</subject><subject>REM Sleep Behavior Disorder - diagnosis</subject><subject>REM Sleep Behavior Disorder - metabolism</subject><subject>Volume</subject><issn>1353-8020</issn><issn>1873-5126</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUstu1DAUjRCIPuAXkJdsEq4fcTwbJKgGqFSExGNtOc5N62nGTm1n1P49jqaAxKre2Nc651z7nFtVhEJDgcp3u2Y28TbiNLjUMKCiAd4A48-qU6o6XreUyeflzFteK2BwUp2ltAOArgX-sjphouO0Zeq0ut8ezLSY7IInYSR9NM4TF0tlg8_oM1nrwYXZ5BtnyfftV5ImxJn0eGMOLkRS3hDigJEsyflrcrcYn10ukgcke3PtMRdexBS88RaJK3cF96p6MZop4evH_bz69Wn78-JLffXt8-XFh6vaCslyLRjbWDGMpgPsVdvRHsH0AhWnkgsuesUo36iNQoBNJ5HC0HZi7IRSHSIb-Xn19qg7x3C3YMp675LFaTIew5I0bYUAYILJJ0C5lIpJRQtUHaE2hpQijnqO5WPxQVPQa0R6p_9FpNeINHBdIirUN49dln6Pw1_in0wK4OMRgMWWg8Ook3VYrBtcRJv1ENxTurz_T8ROzjtrplt8wLQLS_TFdk11Yhr0j3VU1kmhxQzKy_oNAze9Jg</recordid><startdate>20140701</startdate><enddate>20140701</enddate><creator>Lee, Jae-Hyeok</creator><creator>Han, Yong-Hee</creator><creator>Cho, Jae-Wook</creator><creator>Lee, Jin-Seong</creator><creator>Lee, Sang-Jae</creator><creator>Kim, Dae-Jin</creator><creator>Kim, Tae-Hyoung</creator><creator>Kang, Bok-Man</creator><creator>Kim, Tae-Hyung</creator><creator>Mun, Chi-Woong</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20140701</creationdate><title>Evaluation of brain iron content in idiopathic REM sleep behavior disorder using quantitative magnetic resonance imaging</title><author>Lee, Jae-Hyeok ; Han, Yong-Hee ; Cho, Jae-Wook ; Lee, Jin-Seong ; Lee, Sang-Jae ; Kim, Dae-Jin ; Kim, Tae-Hyoung ; Kang, Bok-Man ; Kim, Tae-Hyung ; Mun, Chi-Woong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-4229c4dfa70eb8571be0ab4e83163434b82139898e00976e10d574f74887ee2f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Biomarkers - metabolism</topic><topic>Brain - metabolism</topic><topic>Brain Chemistry - physiology</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Idiopathic REM sleep behavior disorder</topic><topic>Iron</topic><topic>Iron - analysis</topic><topic>Iron - metabolism</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>MRI</topic><topic>Neurology</topic><topic>Parkinson Disease - diagnosis</topic><topic>Parkinson Disease - metabolism</topic><topic>REM Sleep Behavior Disorder - diagnosis</topic><topic>REM Sleep Behavior Disorder - metabolism</topic><topic>Volume</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Jae-Hyeok</creatorcontrib><creatorcontrib>Han, Yong-Hee</creatorcontrib><creatorcontrib>Cho, Jae-Wook</creatorcontrib><creatorcontrib>Lee, Jin-Seong</creatorcontrib><creatorcontrib>Lee, Sang-Jae</creatorcontrib><creatorcontrib>Kim, Dae-Jin</creatorcontrib><creatorcontrib>Kim, Tae-Hyoung</creatorcontrib><creatorcontrib>Kang, Bok-Man</creatorcontrib><creatorcontrib>Kim, Tae-Hyung</creatorcontrib><creatorcontrib>Mun, Chi-Woong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Parkinsonism & related disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Jae-Hyeok</au><au>Han, Yong-Hee</au><au>Cho, Jae-Wook</au><au>Lee, Jin-Seong</au><au>Lee, Sang-Jae</au><au>Kim, Dae-Jin</au><au>Kim, Tae-Hyoung</au><au>Kang, Bok-Man</au><au>Kim, Tae-Hyung</au><au>Mun, Chi-Woong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of brain iron content in idiopathic REM sleep behavior disorder using quantitative magnetic resonance imaging</atitle><jtitle>Parkinsonism & related disorders</jtitle><addtitle>Parkinsonism Relat Disord</addtitle><date>2014-07-01</date><risdate>2014</risdate><volume>20</volume><issue>7</issue><spage>776</spage><epage>778</epage><pages>776-778</pages><issn>1353-8020</issn><eissn>1873-5126</eissn><abstract>Abstract Background Neuroimaging studies in patients with idiopathic rapid eye movement sleep behavior disorder (iRBD) show similar structural and functional changes to alpha-synucleinopathies, including PD. Until now, there have been few attempts to characterize brain iron deposition in iRBD. The aim of this study was to investigate brain iron content in patients with iRBD using quantitative magnetic resonance imaging (MRI). Methods 3-T MRI was performed in 15 patients with iRBD and 20 age-matched healthy control subjects. In order to evaluate the iron-related neurodegenerative changes, we assessed volume and transverse relaxation rate (R2*) simultaneously. We used both region-based and voxel-based analysis. Results No significant differences in R2* values were found between iRBD groups and healthy control subjects. There were no areas of significantly reduced or increased gray matter and white matter volume in the iRBD group. Instead, lateral ventricle volumes measured automatically by FreeSurfer were significantly larger in patients with iRBD than in healthy controls ( P < 0.05). Conclusion The present study suggests that iron-related R2* values may not be an imaging biomarker for neurodegeneration in iRBD.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>24731528</pmid><doi>10.1016/j.parkreldis.2014.03.023</doi><tpages>3</tpages></addata></record> |
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| subjects | Aged Biomarkers - metabolism Brain - metabolism Brain Chemistry - physiology Cross-Sectional Studies Female Humans Idiopathic REM sleep behavior disorder Iron Iron - analysis Iron - metabolism Magnetic Resonance Imaging - methods Male Middle Aged MRI Neurology Parkinson Disease - diagnosis Parkinson Disease - metabolism REM Sleep Behavior Disorder - diagnosis REM Sleep Behavior Disorder - metabolism Volume |
| title | Evaluation of brain iron content in idiopathic REM sleep behavior disorder using quantitative magnetic resonance imaging |
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