Gray Matter Volume in Left Rostral Middle Frontal and Left Cerebellar Cortices Predicts Frontal Executive Performance in Alcoholic Subjects
Background Alcoholic subjects manifest important deficits in frontal executive function, yet maintain cognitive mental status within normal range. Methods This study searched for volumetric measurements of segmented brain structures obtained from magnetic resonance imaging (MRI) that would predict e...
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| Veröffentlicht in: | Alcoholism, clinical and experimental research clinical and experimental research, 2014-04, Vol.38 (4), p.1126-1133 |
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| creator | Nakamura-Palacios, Ester M. Souza, Rodrigo S. M. Zago-Gomes, Maria P. de Melo, Adriana M. F. Braga, Flávia S. Kubo, Tadeu T. A. Gasparetto, Emerson L. |
| description | Background
Alcoholic subjects manifest important deficits in frontal executive function, yet maintain cognitive mental status within normal range.
Methods
This study searched for volumetric measurements of segmented brain structures obtained from magnetic resonance imaging (MRI) that would predict executive functions and cognitive mental status in alcoholic subjects. The frontal assessment battery (FAB) and the Mini‐Mental State Examination (MMSE) were applied to alcoholic subjects who underwent MRI. Cortical and subcortical segmentation and corrections were performed using FreeSurfer. Multiple linear regressions analyses having volumetric measures of segmented brain structures as predictors for FAB or MMSE scores as dependent measures were conducted. Sixty alcoholic subjects, 52 males, mean age of 47.2 ± SD 10.4 years, with heavy use of alcohol (mean 284.4 ± SD 275.9 g of alcohol/d) over a long time (mean 32.4 ± SD 11.1 years), showed FAB 11.1 ± SD 3.2 and MMSE of 25.2 ± SD 4.1.
Results
Multiple regression analyses having left and right side of each segment as predictors showed that gray matter volumes of rostral middle frontal cortex and cerebellar cortex (p |
| doi_str_mv | 10.1111/acer.12308 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1544001751</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1544001751</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5158-844c1013c133ee895480db512140949bb592b9aaeede146ba653dbd83a9906de3</originalsourceid><addsrcrecordid>eNqN0ctu1DAUBuAIgehQ2PAAyBIbhJTiE1_iLEdhOiClUIZLl5ZjnxEZMnFrJ23nGXhpMk07CxYIbyzL3_kt60-Sl0BPYFzvjMVwAhmj6lEyA8FoSrM8f5zMKHCRSkrVUfIsxg2llCspnyZHGc-ElBnMkt_LYHbkzPQ9BvLDt8MWSdORCtc9WfnYB9OSs8a5Fslp8F0_Hk3npvsSA9bYtiaQ0oe-sRjJeUDX2D4e9OIW7dA310jOMax92JrO3j0xb63_6dvGkq9DvcFx5nnyZG3aiC_u9-Pk--niW_khrT4vP5bzKrUChEoV5xYoMAuMIapCcEVdLSADTgte1LUosrowBtEhcFkbKZirnWKmKKh0yI6TN1PuZfBXA8Zeb5to9x_p0A9Rg-CcUsgF_AcFIbmUXI309V9044fQjR_ZK6ayAoCP6u2kbPAxBlzry9BsTdhpoHrfpt63qe_aHPGr-8ih3qI70If6RgATuGla3P0jSs_LxeohNJ1mmtjj7WHGhF9a5iwX-uLTUlfy4sv7VSX1iv0Bfcu4mg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1513829114</pqid></control><display><type>article</type><title>Gray Matter Volume in Left Rostral Middle Frontal and Left Cerebellar Cortices Predicts Frontal Executive Performance in Alcoholic Subjects</title><source>Journals@Ovid Ovid Autoload</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Nakamura-Palacios, Ester M. ; Souza, Rodrigo S. M. ; Zago-Gomes, Maria P. ; de Melo, Adriana M. F. ; Braga, Flávia S. ; Kubo, Tadeu T. A. ; Gasparetto, Emerson L.</creator><creatorcontrib>Nakamura-Palacios, Ester M. ; Souza, Rodrigo S. M. ; Zago-Gomes, Maria P. ; de Melo, Adriana M. F. ; Braga, Flávia S. ; Kubo, Tadeu T. A. ; Gasparetto, Emerson L.</creatorcontrib><description>Background
Alcoholic subjects manifest important deficits in frontal executive function, yet maintain cognitive mental status within normal range.
Methods
This study searched for volumetric measurements of segmented brain structures obtained from magnetic resonance imaging (MRI) that would predict executive functions and cognitive mental status in alcoholic subjects. The frontal assessment battery (FAB) and the Mini‐Mental State Examination (MMSE) were applied to alcoholic subjects who underwent MRI. Cortical and subcortical segmentation and corrections were performed using FreeSurfer. Multiple linear regressions analyses having volumetric measures of segmented brain structures as predictors for FAB or MMSE scores as dependent measures were conducted. Sixty alcoholic subjects, 52 males, mean age of 47.2 ± SD 10.4 years, with heavy use of alcohol (mean 284.4 ± SD 275.9 g of alcohol/d) over a long time (mean 32.4 ± SD 11.1 years), showed FAB 11.1 ± SD 3.2 and MMSE of 25.2 ± SD 4.1.
Results
Multiple regression analyses having left and right side of each segment as predictors showed that gray matter volumes of rostral middle frontal cortex and cerebellar cortex (p < 0.001), in which only the left side of these structures showed significant partial effects in the full model (p < 0.05), showed to predict FAB performance. They were even more predictive when considered together (p < 0.001), in which both left rostral middle frontal cortex (p < 0.05) and left cerebellar cortex (p < 0.01) predictors had significant partial effects in the full model. None of brain structures was predictive of MMSE performance.
Conclusions
We have concluded that volumetric measurements of left rostral middle frontal and cerebellar cortices seem to be able to predict the frontal executive performance but not the cognitive mental status in alcoholic subjects.</description><identifier>ISSN: 0145-6008</identifier><identifier>EISSN: 1530-0277</identifier><identifier>DOI: 10.1111/acer.12308</identifier><identifier>PMID: 24256621</identifier><identifier>CODEN: ACRSDM</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Alcoholism ; Alcoholism - diagnosis ; Alcoholism - psychology ; Brief Psychiatric Rating Scale ; Cerebellar Cortex - pathology ; Cognition ; Executive Function ; Executive Function - physiology ; Female ; Frontal Lobe - pathology ; Gray Matter - pathology ; Humans ; Magnetic Resonance Imaging ; Magnetic Resonance Imaging - methods ; Male ; Middle Aged ; Organ Size ; Predictive Value of Tests ; Prefrontal Cortex ; Young Adult</subject><ispartof>Alcoholism, clinical and experimental research, 2014-04, Vol.38 (4), p.1126-1133</ispartof><rights>Copyright © 2013 by the Research Society on Alcoholism</rights><rights>Copyright © 2013 by the Research Society on Alcoholism.</rights><rights>2014 Research Society on Alcoholism</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5158-844c1013c133ee895480db512140949bb592b9aaeede146ba653dbd83a9906de3</citedby><cites>FETCH-LOGICAL-c5158-844c1013c133ee895480db512140949bb592b9aaeede146ba653dbd83a9906de3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Facer.12308$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Facer.12308$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24256621$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakamura-Palacios, Ester M.</creatorcontrib><creatorcontrib>Souza, Rodrigo S. M.</creatorcontrib><creatorcontrib>Zago-Gomes, Maria P.</creatorcontrib><creatorcontrib>de Melo, Adriana M. F.</creatorcontrib><creatorcontrib>Braga, Flávia S.</creatorcontrib><creatorcontrib>Kubo, Tadeu T. A.</creatorcontrib><creatorcontrib>Gasparetto, Emerson L.</creatorcontrib><title>Gray Matter Volume in Left Rostral Middle Frontal and Left Cerebellar Cortices Predicts Frontal Executive Performance in Alcoholic Subjects</title><title>Alcoholism, clinical and experimental research</title><addtitle>Alcohol Clin Exp Res</addtitle><description>Background
Alcoholic subjects manifest important deficits in frontal executive function, yet maintain cognitive mental status within normal range.
Methods
This study searched for volumetric measurements of segmented brain structures obtained from magnetic resonance imaging (MRI) that would predict executive functions and cognitive mental status in alcoholic subjects. The frontal assessment battery (FAB) and the Mini‐Mental State Examination (MMSE) were applied to alcoholic subjects who underwent MRI. Cortical and subcortical segmentation and corrections were performed using FreeSurfer. Multiple linear regressions analyses having volumetric measures of segmented brain structures as predictors for FAB or MMSE scores as dependent measures were conducted. Sixty alcoholic subjects, 52 males, mean age of 47.2 ± SD 10.4 years, with heavy use of alcohol (mean 284.4 ± SD 275.9 g of alcohol/d) over a long time (mean 32.4 ± SD 11.1 years), showed FAB 11.1 ± SD 3.2 and MMSE of 25.2 ± SD 4.1.
Results
Multiple regression analyses having left and right side of each segment as predictors showed that gray matter volumes of rostral middle frontal cortex and cerebellar cortex (p < 0.001), in which only the left side of these structures showed significant partial effects in the full model (p < 0.05), showed to predict FAB performance. They were even more predictive when considered together (p < 0.001), in which both left rostral middle frontal cortex (p < 0.05) and left cerebellar cortex (p < 0.01) predictors had significant partial effects in the full model. None of brain structures was predictive of MMSE performance.
Conclusions
We have concluded that volumetric measurements of left rostral middle frontal and cerebellar cortices seem to be able to predict the frontal executive performance but not the cognitive mental status in alcoholic subjects.</description><subject>Adult</subject><subject>Aged</subject><subject>Alcoholism</subject><subject>Alcoholism - diagnosis</subject><subject>Alcoholism - psychology</subject><subject>Brief Psychiatric Rating Scale</subject><subject>Cerebellar Cortex - pathology</subject><subject>Cognition</subject><subject>Executive Function</subject><subject>Executive Function - physiology</subject><subject>Female</subject><subject>Frontal Lobe - pathology</subject><subject>Gray Matter - pathology</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Organ Size</subject><subject>Predictive Value of Tests</subject><subject>Prefrontal Cortex</subject><subject>Young Adult</subject><issn>0145-6008</issn><issn>1530-0277</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0ctu1DAUBuAIgehQ2PAAyBIbhJTiE1_iLEdhOiClUIZLl5ZjnxEZMnFrJ23nGXhpMk07CxYIbyzL3_kt60-Sl0BPYFzvjMVwAhmj6lEyA8FoSrM8f5zMKHCRSkrVUfIsxg2llCspnyZHGc-ElBnMkt_LYHbkzPQ9BvLDt8MWSdORCtc9WfnYB9OSs8a5Fslp8F0_Hk3npvsSA9bYtiaQ0oe-sRjJeUDX2D4e9OIW7dA310jOMax92JrO3j0xb63_6dvGkq9DvcFx5nnyZG3aiC_u9-Pk--niW_khrT4vP5bzKrUChEoV5xYoMAuMIapCcEVdLSADTgte1LUosrowBtEhcFkbKZirnWKmKKh0yI6TN1PuZfBXA8Zeb5to9x_p0A9Rg-CcUsgF_AcFIbmUXI309V9044fQjR_ZK6ayAoCP6u2kbPAxBlzry9BsTdhpoHrfpt63qe_aHPGr-8ih3qI70If6RgATuGla3P0jSs_LxeohNJ1mmtjj7WHGhF9a5iwX-uLTUlfy4sv7VSX1iv0Bfcu4mg</recordid><startdate>201404</startdate><enddate>201404</enddate><creator>Nakamura-Palacios, Ester M.</creator><creator>Souza, Rodrigo S. M.</creator><creator>Zago-Gomes, Maria P.</creator><creator>de Melo, Adriana M. F.</creator><creator>Braga, Flávia S.</creator><creator>Kubo, Tadeu T. A.</creator><creator>Gasparetto, Emerson L.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K7.</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201404</creationdate><title>Gray Matter Volume in Left Rostral Middle Frontal and Left Cerebellar Cortices Predicts Frontal Executive Performance in Alcoholic Subjects</title><author>Nakamura-Palacios, Ester M. ; Souza, Rodrigo S. M. ; Zago-Gomes, Maria P. ; de Melo, Adriana M. F. ; Braga, Flávia S. ; Kubo, Tadeu T. A. ; Gasparetto, Emerson L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5158-844c1013c133ee895480db512140949bb592b9aaeede146ba653dbd83a9906de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Alcoholism</topic><topic>Alcoholism - diagnosis</topic><topic>Alcoholism - psychology</topic><topic>Brief Psychiatric Rating Scale</topic><topic>Cerebellar Cortex - pathology</topic><topic>Cognition</topic><topic>Executive Function</topic><topic>Executive Function - physiology</topic><topic>Female</topic><topic>Frontal Lobe - pathology</topic><topic>Gray Matter - pathology</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Organ Size</topic><topic>Predictive Value of Tests</topic><topic>Prefrontal Cortex</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakamura-Palacios, Ester M.</creatorcontrib><creatorcontrib>Souza, Rodrigo S. M.</creatorcontrib><creatorcontrib>Zago-Gomes, Maria P.</creatorcontrib><creatorcontrib>de Melo, Adriana M. F.</creatorcontrib><creatorcontrib>Braga, Flávia S.</creatorcontrib><creatorcontrib>Kubo, Tadeu T. A.</creatorcontrib><creatorcontrib>Gasparetto, Emerson L.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Criminal Justice (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Alcoholism, clinical and experimental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakamura-Palacios, Ester M.</au><au>Souza, Rodrigo S. M.</au><au>Zago-Gomes, Maria P.</au><au>de Melo, Adriana M. F.</au><au>Braga, Flávia S.</au><au>Kubo, Tadeu T. A.</au><au>Gasparetto, Emerson L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gray Matter Volume in Left Rostral Middle Frontal and Left Cerebellar Cortices Predicts Frontal Executive Performance in Alcoholic Subjects</atitle><jtitle>Alcoholism, clinical and experimental research</jtitle><addtitle>Alcohol Clin Exp Res</addtitle><date>2014-04</date><risdate>2014</risdate><volume>38</volume><issue>4</issue><spage>1126</spage><epage>1133</epage><pages>1126-1133</pages><issn>0145-6008</issn><eissn>1530-0277</eissn><coden>ACRSDM</coden><abstract>Background
Alcoholic subjects manifest important deficits in frontal executive function, yet maintain cognitive mental status within normal range.
Methods
This study searched for volumetric measurements of segmented brain structures obtained from magnetic resonance imaging (MRI) that would predict executive functions and cognitive mental status in alcoholic subjects. The frontal assessment battery (FAB) and the Mini‐Mental State Examination (MMSE) were applied to alcoholic subjects who underwent MRI. Cortical and subcortical segmentation and corrections were performed using FreeSurfer. Multiple linear regressions analyses having volumetric measures of segmented brain structures as predictors for FAB or MMSE scores as dependent measures were conducted. Sixty alcoholic subjects, 52 males, mean age of 47.2 ± SD 10.4 years, with heavy use of alcohol (mean 284.4 ± SD 275.9 g of alcohol/d) over a long time (mean 32.4 ± SD 11.1 years), showed FAB 11.1 ± SD 3.2 and MMSE of 25.2 ± SD 4.1.
Results
Multiple regression analyses having left and right side of each segment as predictors showed that gray matter volumes of rostral middle frontal cortex and cerebellar cortex (p < 0.001), in which only the left side of these structures showed significant partial effects in the full model (p < 0.05), showed to predict FAB performance. They were even more predictive when considered together (p < 0.001), in which both left rostral middle frontal cortex (p < 0.05) and left cerebellar cortex (p < 0.01) predictors had significant partial effects in the full model. None of brain structures was predictive of MMSE performance.
Conclusions
We have concluded that volumetric measurements of left rostral middle frontal and cerebellar cortices seem to be able to predict the frontal executive performance but not the cognitive mental status in alcoholic subjects.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>24256621</pmid><doi>10.1111/acer.12308</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0145-6008 |
| ispartof | Alcoholism, clinical and experimental research, 2014-04, Vol.38 (4), p.1126-1133 |
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| language | eng |
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| source | Journals@Ovid Ovid Autoload; MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Aged Alcoholism Alcoholism - diagnosis Alcoholism - psychology Brief Psychiatric Rating Scale Cerebellar Cortex - pathology Cognition Executive Function Executive Function - physiology Female Frontal Lobe - pathology Gray Matter - pathology Humans Magnetic Resonance Imaging Magnetic Resonance Imaging - methods Male Middle Aged Organ Size Predictive Value of Tests Prefrontal Cortex Young Adult |
| title | Gray Matter Volume in Left Rostral Middle Frontal and Left Cerebellar Cortices Predicts Frontal Executive Performance in Alcoholic Subjects |
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