Discovery of Heterocyclic Nonacetamide Synaptic Vesicle Protein2A (SV2A) Ligands with Single-Digit Nanomolar Potency: Opening Avenues towards the First SV2A Positron Emission Tomography (PET) Ligands

The role of the synaptic vesicle protein2A (SV2A) protein, target of the antiepileptic drug levetiracetam, is still mostly unknown. Considering its potential to provide in vivo functional insights into the role of SV2A in epileptic patients, the development of an SV2A positron emission tomography (P...

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Veröffentlicht in:	ChemMedChem 2014-04, Vol.9 (4), p.693-698
Hauptverfasser:	Mercier, Joël, Archen, Laurence, Bollu, Véronique, Carre, Stéphane, Evrard, Yves, Jnoff, Eric, Kenda, Benoît, Lallemand, Bénédicte, Michel, Philippe, Montel, Florian, Moureau, Florence, Price, Nathalie, Quesnel, Yannick, Sauvage, Xavier, Valade, Anne, Provins, Laurent
Format:	Artikel
Sprache:	eng ; ger
Schlagworte:	Epilepsy Ligands Tomography
Online-Zugang:	Volltext
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