Combination of 2-methoxy-3-phenylsulfonylaminobenzamide and 2-aminobenzothiazole to discover novel anticancer agents

The structure of benzamide can replace the complex of the pyridine in compound A with water molecule to design novel anticancer agents based on bioisostere. The fragment of 2-substituted-3-sulfonylaminobenzamide has been proposed to replace the fragment of 2-substituted-3-sulfonylaminopyridine in PI...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2014-07, Vol.22 (14), p.3739-3748
Hauptverfasser:	Li, Huan, Wang, Xiao-Meng, Wang, Juan, Shao, Teng, Li, Yi-Ping, Mei, Qi-Bing, Lu, She-Min, Zhang, San-Qi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticancer effect Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Benzamide Benzothiazole Benzothiazoles - chemistry Benzothiazoles - pharmacology Bioisostere Cell Proliferation - drug effects Dose-Response Relationship, Drug Drug Screening Assays, Antitumor HCT116 Cells Humans MCF-7 Cells Mice Mice, Inbred BALB C Mice, Nude Models, Molecular Molecular Structure Neoplasms, Experimental - drug therapy Neoplasms, Experimental - pathology Structure-Activity Relationship Sulfonamides - chemistry Sulfonamides - pharmacology Synthesis Tumor Cells, Cultured
Online-Zugang:	Volltext
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