Increased endothelial activation in recently symptomatic versus asymptomatic carotid artery stenosis and in cerebral microembolic-signal-negative patient subgroups
Background and purpose von Willebrand factor propeptide (VWF:Ag II) is potentially a more sensitive marker of acute endothelial activation than von Willebrand factor antigen (VWF:Ag). These biomarkers have not been simultaneously assessed in asymptomatic versus symptomatic carotid stenosis patients....
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| Veröffentlicht in: | European journal of neurology 2014-07, Vol.21 (7), p.969-e55 |
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| creator | Kinsella, J. A. Tobin, W. O. Kavanagh, G. F. O'Donnell, J. S. McGrath, R. T. Tierney, S. Feeley, T. M. Egan, B. O'Neill, D. Collins, R. D. Coughlan, T. Harbison, J. A. Doherty, C. P. Madhavan, P. Moore, D. J. O'Neill, S. M. Colgan, M.-P. Saqqur, M. Murphy, R. P. Moran, N. Hamilton, G. McCabe, D. J. H. |
| description | Background and purpose
von Willebrand factor propeptide (VWF:Ag II) is potentially a more sensitive marker of acute endothelial activation than von Willebrand factor antigen (VWF:Ag). These biomarkers have not been simultaneously assessed in asymptomatic versus symptomatic carotid stenosis patients. The relationship between endothelial activation and cerebral microembolic signals (MESs) detected on transcranial Doppler ultrasound is unknown.
Methods
In this multicentre observational analytical study, plasma VWF:Ag and VWF:Ag II levels in patients with ≥50% asymptomatic carotid stenosis were compared with those from patients with ≥50% symptomatic carotid stenosis in the ‘early’ (≤4 weeks) and ‘late’ (≥3 months) phases after transient ischaemic attack or ischaemic stroke. Endothelial activation was also longitudinally assessed in symptomatic patients during follow‐up. Transcranial Doppler ultrasound monitoring classified patients as MES‐positive or MES‐negative.
Results
Data from 31 asymptomatic patients were compared with those from 46 early symptomatic and 35 late phase symptomatic carotid stenosis patients, 23 of whom had undergone carotid intervention. VWF:Ag II levels were higher in early (12.8 μg/ml; P |
| doi_str_mv | 10.1111/ene.12403 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1544000462</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3331540421</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5253-48875fc3e748d0a776b4147082e81e3be011c68afcf6b7ff79f2ce4d0091377a3</originalsourceid><addsrcrecordid>eNqNkctu1DAUhi0EoqWw4AWQJTZlkdbX2FmiaiiVqqELLkvLcU4Gl8QOdjIwz8OL4nbaCiEh4c2x7O98ls-P0EtKTmhZpxDghDJB-CN0SEWtK8o5fVz2XNJKUkIP0LOcrwkhTDHyFB0woSirhT5Evy6CS2AzdBhCF-evMHg7YOtmv7WzjwH7gBM4CPOww3k3TnMcy4XDW0h5ydj-eeZsirPvsE0zpILPEGL2BQrdjcdBgjYV_ehdijC2cfCuyn4T7FAF2BTHFvBUSnkO56XdpLhM-Tl60tshw4u7eoQ-vVt9PHtfXX44vzh7e1k5ySSvhNZK9o6DErojVqm6FVQoohloCrwFQqmrte1dX7eq71XTMweiI6ShXCnLj9Dx3jul-H2BPJvRZwfDYAPEJRsqhSgzFDX7D5TLmmmhVUFf_4VexyWVH99SQolGsqZQb_ZUGUzOCXozJT_atDOUmJuQTQnZ3IZc2Fd3xqUdoXsg71MtwOke-OEH2P3bZFbr1b2y2nf4ktnPhw6bvplacSXNl_W5EWv6ubm6koby36Ycw1U</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1534749529</pqid></control><display><type>article</type><title>Increased endothelial activation in recently symptomatic versus asymptomatic carotid artery stenosis and in cerebral microembolic-signal-negative patient subgroups</title><source>Wiley Online Library - AutoHoldings Journals</source><source>MEDLINE</source><creator>Kinsella, J. A. ; Tobin, W. O. ; Kavanagh, G. F. ; O'Donnell, J. S. ; McGrath, R. T. ; Tierney, S. ; Feeley, T. M. ; Egan, B. ; O'Neill, D. ; Collins, R. D. ; Coughlan, T. ; Harbison, J. A. ; Doherty, C. P. ; Madhavan, P. ; Moore, D. J. ; O'Neill, S. M. ; Colgan, M.-P. ; Saqqur, M. ; Murphy, R. P. ; Moran, N. ; Hamilton, G. ; McCabe, D. J. H.</creator><creatorcontrib>Kinsella, J. A. ; Tobin, W. O. ; Kavanagh, G. F. ; O'Donnell, J. S. ; McGrath, R. T. ; Tierney, S. ; Feeley, T. M. ; Egan, B. ; O'Neill, D. ; Collins, R. D. ; Coughlan, T. ; Harbison, J. A. ; Doherty, C. P. ; Madhavan, P. ; Moore, D. J. ; O'Neill, S. M. ; Colgan, M.-P. ; Saqqur, M. ; Murphy, R. P. ; Moran, N. ; Hamilton, G. ; McCabe, D. J. H.</creatorcontrib><description>Background and purpose
von Willebrand factor propeptide (VWF:Ag II) is potentially a more sensitive marker of acute endothelial activation than von Willebrand factor antigen (VWF:Ag). These biomarkers have not been simultaneously assessed in asymptomatic versus symptomatic carotid stenosis patients. The relationship between endothelial activation and cerebral microembolic signals (MESs) detected on transcranial Doppler ultrasound is unknown.
Methods
In this multicentre observational analytical study, plasma VWF:Ag and VWF:Ag II levels in patients with ≥50% asymptomatic carotid stenosis were compared with those from patients with ≥50% symptomatic carotid stenosis in the ‘early’ (≤4 weeks) and ‘late’ (≥3 months) phases after transient ischaemic attack or ischaemic stroke. Endothelial activation was also longitudinally assessed in symptomatic patients during follow‐up. Transcranial Doppler ultrasound monitoring classified patients as MES‐positive or MES‐negative.
Results
Data from 31 asymptomatic patients were compared with those from 46 early symptomatic and 35 late phase symptomatic carotid stenosis patients, 23 of whom had undergone carotid intervention. VWF:Ag II levels were higher in early (12.8 μg/ml; P < 0.001), late (10.6 μg/ml; P = 0.01) and late post‐intervention (10.6 μg/ml; P = 0.038) symptomatic patients than asymptomatic patients (8.9 μg/ml). VWF:Ag levels decreased in symptomatic patients followed up from the early to late phase after symptom onset (P = 0.048). Early symptomatic MES‐negative patients had higher VWF: Ag II levels (13.3 vs. 9.0 μg/ml; P < 0.001) than asymptomatic MES‐negative patients.
Conclusions
Endothelial activation is enhanced in symptomatic versus asymptomatic carotid stenosis patients, in early symptomatic versus asymptomatic MES‐negative patients, and decreases over time in symptomatic patients. VWF:Ag II levels are a more sensitive marker of endothelial activation than VWF:Ag levels in carotid stenosis. The potential value of endothelial biomarkers and concurrent cerebral MES detection at predicting stroke risk in carotid stenosis warrants further study.</description><identifier>ISSN: 1351-5101</identifier><identifier>EISSN: 1468-1331</identifier><identifier>DOI: 10.1111/ene.12403</identifier><identifier>PMID: 24712648</identifier><identifier>CODEN: EJNEFL</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Aged ; Angioplasty ; Biomarkers ; Biomarkers - blood ; Brain Ischemia - etiology ; carotid stenosis ; Carotid Stenosis - blood ; Carotid Stenosis - complications ; Carotid Stenosis - diagnostic imaging ; cerebral microemboli ; Endothelium - metabolism ; Endothelium - secretion ; Humans ; Intracranial Embolism - blood ; Intracranial Embolism - diagnostic imaging ; Ischemic Attack, Transient - etiology ; Male ; Middle Aged ; Older people ; stroke ; Stroke - etiology ; transient ischaemic attack ; Ultrasonography ; von Willebrand Factor</subject><ispartof>European journal of neurology, 2014-07, Vol.21 (7), p.969-e55</ispartof><rights>2014 The Author(s) European Journal of Neurology © 2014 EAN</rights><rights>2014 The Author(s) European Journal of Neurology © 2014 EAN.</rights><rights>European Journal of Neurology © 2014 European Federation of Neurological Societies</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5253-48875fc3e748d0a776b4147082e81e3be011c68afcf6b7ff79f2ce4d0091377a3</citedby><cites>FETCH-LOGICAL-c5253-48875fc3e748d0a776b4147082e81e3be011c68afcf6b7ff79f2ce4d0091377a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fene.12403$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fene.12403$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24712648$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kinsella, J. A.</creatorcontrib><creatorcontrib>Tobin, W. O.</creatorcontrib><creatorcontrib>Kavanagh, G. F.</creatorcontrib><creatorcontrib>O'Donnell, J. S.</creatorcontrib><creatorcontrib>McGrath, R. T.</creatorcontrib><creatorcontrib>Tierney, S.</creatorcontrib><creatorcontrib>Feeley, T. M.</creatorcontrib><creatorcontrib>Egan, B.</creatorcontrib><creatorcontrib>O'Neill, D.</creatorcontrib><creatorcontrib>Collins, R. D.</creatorcontrib><creatorcontrib>Coughlan, T.</creatorcontrib><creatorcontrib>Harbison, J. A.</creatorcontrib><creatorcontrib>Doherty, C. P.</creatorcontrib><creatorcontrib>Madhavan, P.</creatorcontrib><creatorcontrib>Moore, D. J.</creatorcontrib><creatorcontrib>O'Neill, S. M.</creatorcontrib><creatorcontrib>Colgan, M.-P.</creatorcontrib><creatorcontrib>Saqqur, M.</creatorcontrib><creatorcontrib>Murphy, R. P.</creatorcontrib><creatorcontrib>Moran, N.</creatorcontrib><creatorcontrib>Hamilton, G.</creatorcontrib><creatorcontrib>McCabe, D. J. H.</creatorcontrib><title>Increased endothelial activation in recently symptomatic versus asymptomatic carotid artery stenosis and in cerebral microembolic-signal-negative patient subgroups</title><title>European journal of neurology</title><addtitle>Eur J Neurol</addtitle><description>Background and purpose
von Willebrand factor propeptide (VWF:Ag II) is potentially a more sensitive marker of acute endothelial activation than von Willebrand factor antigen (VWF:Ag). These biomarkers have not been simultaneously assessed in asymptomatic versus symptomatic carotid stenosis patients. The relationship between endothelial activation and cerebral microembolic signals (MESs) detected on transcranial Doppler ultrasound is unknown.
Methods
In this multicentre observational analytical study, plasma VWF:Ag and VWF:Ag II levels in patients with ≥50% asymptomatic carotid stenosis were compared with those from patients with ≥50% symptomatic carotid stenosis in the ‘early’ (≤4 weeks) and ‘late’ (≥3 months) phases after transient ischaemic attack or ischaemic stroke. Endothelial activation was also longitudinally assessed in symptomatic patients during follow‐up. Transcranial Doppler ultrasound monitoring classified patients as MES‐positive or MES‐negative.
Results
Data from 31 asymptomatic patients were compared with those from 46 early symptomatic and 35 late phase symptomatic carotid stenosis patients, 23 of whom had undergone carotid intervention. VWF:Ag II levels were higher in early (12.8 μg/ml; P < 0.001), late (10.6 μg/ml; P = 0.01) and late post‐intervention (10.6 μg/ml; P = 0.038) symptomatic patients than asymptomatic patients (8.9 μg/ml). VWF:Ag levels decreased in symptomatic patients followed up from the early to late phase after symptom onset (P = 0.048). Early symptomatic MES‐negative patients had higher VWF: Ag II levels (13.3 vs. 9.0 μg/ml; P < 0.001) than asymptomatic MES‐negative patients.
Conclusions
Endothelial activation is enhanced in symptomatic versus asymptomatic carotid stenosis patients, in early symptomatic versus asymptomatic MES‐negative patients, and decreases over time in symptomatic patients. VWF:Ag II levels are a more sensitive marker of endothelial activation than VWF:Ag levels in carotid stenosis. The potential value of endothelial biomarkers and concurrent cerebral MES detection at predicting stroke risk in carotid stenosis warrants further study.</description><subject>Aged</subject><subject>Angioplasty</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Brain Ischemia - etiology</subject><subject>carotid stenosis</subject><subject>Carotid Stenosis - blood</subject><subject>Carotid Stenosis - complications</subject><subject>Carotid Stenosis - diagnostic imaging</subject><subject>cerebral microemboli</subject><subject>Endothelium - metabolism</subject><subject>Endothelium - secretion</subject><subject>Humans</subject><subject>Intracranial Embolism - blood</subject><subject>Intracranial Embolism - diagnostic imaging</subject><subject>Ischemic Attack, Transient - etiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Older people</subject><subject>stroke</subject><subject>Stroke - etiology</subject><subject>transient ischaemic attack</subject><subject>Ultrasonography</subject><subject>von Willebrand Factor</subject><issn>1351-5101</issn><issn>1468-1331</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkctu1DAUhi0EoqWw4AWQJTZlkdbX2FmiaiiVqqELLkvLcU4Gl8QOdjIwz8OL4nbaCiEh4c2x7O98ls-P0EtKTmhZpxDghDJB-CN0SEWtK8o5fVz2XNJKUkIP0LOcrwkhTDHyFB0woSirhT5Evy6CS2AzdBhCF-evMHg7YOtmv7WzjwH7gBM4CPOww3k3TnMcy4XDW0h5ydj-eeZsirPvsE0zpILPEGL2BQrdjcdBgjYV_ehdijC2cfCuyn4T7FAF2BTHFvBUSnkO56XdpLhM-Tl60tshw4u7eoQ-vVt9PHtfXX44vzh7e1k5ySSvhNZK9o6DErojVqm6FVQoohloCrwFQqmrte1dX7eq71XTMweiI6ShXCnLj9Dx3jul-H2BPJvRZwfDYAPEJRsqhSgzFDX7D5TLmmmhVUFf_4VexyWVH99SQolGsqZQb_ZUGUzOCXozJT_atDOUmJuQTQnZ3IZc2Fd3xqUdoXsg71MtwOke-OEH2P3bZFbr1b2y2nf4ktnPhw6bvplacSXNl_W5EWv6ubm6koby36Ycw1U</recordid><startdate>201407</startdate><enddate>201407</enddate><creator>Kinsella, J. A.</creator><creator>Tobin, W. O.</creator><creator>Kavanagh, G. F.</creator><creator>O'Donnell, J. S.</creator><creator>McGrath, R. T.</creator><creator>Tierney, S.</creator><creator>Feeley, T. M.</creator><creator>Egan, B.</creator><creator>O'Neill, D.</creator><creator>Collins, R. D.</creator><creator>Coughlan, T.</creator><creator>Harbison, J. A.</creator><creator>Doherty, C. P.</creator><creator>Madhavan, P.</creator><creator>Moore, D. J.</creator><creator>O'Neill, S. M.</creator><creator>Colgan, M.-P.</creator><creator>Saqqur, M.</creator><creator>Murphy, R. P.</creator><creator>Moran, N.</creator><creator>Hamilton, G.</creator><creator>McCabe, D. J. H.</creator><general>Blackwell Publishing Ltd</general><general>John Wiley & Sons, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201407</creationdate><title>Increased endothelial activation in recently symptomatic versus asymptomatic carotid artery stenosis and in cerebral microembolic-signal-negative patient subgroups</title><author>Kinsella, J. A. ; Tobin, W. O. ; Kavanagh, G. F. ; O'Donnell, J. S. ; McGrath, R. T. ; Tierney, S. ; Feeley, T. M. ; Egan, B. ; O'Neill, D. ; Collins, R. D. ; Coughlan, T. ; Harbison, J. A. ; Doherty, C. P. ; Madhavan, P. ; Moore, D. J. ; O'Neill, S. M. ; Colgan, M.-P. ; Saqqur, M. ; Murphy, R. P. ; Moran, N. ; Hamilton, G. ; McCabe, D. J. H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5253-48875fc3e748d0a776b4147082e81e3be011c68afcf6b7ff79f2ce4d0091377a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Angioplasty</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Brain Ischemia - etiology</topic><topic>carotid stenosis</topic><topic>Carotid Stenosis - blood</topic><topic>Carotid Stenosis - complications</topic><topic>Carotid Stenosis - diagnostic imaging</topic><topic>cerebral microemboli</topic><topic>Endothelium - metabolism</topic><topic>Endothelium - secretion</topic><topic>Humans</topic><topic>Intracranial Embolism - blood</topic><topic>Intracranial Embolism - diagnostic imaging</topic><topic>Ischemic Attack, Transient - etiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Older people</topic><topic>stroke</topic><topic>Stroke - etiology</topic><topic>transient ischaemic attack</topic><topic>Ultrasonography</topic><topic>von Willebrand Factor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kinsella, J. A.</creatorcontrib><creatorcontrib>Tobin, W. O.</creatorcontrib><creatorcontrib>Kavanagh, G. F.</creatorcontrib><creatorcontrib>O'Donnell, J. S.</creatorcontrib><creatorcontrib>McGrath, R. T.</creatorcontrib><creatorcontrib>Tierney, S.</creatorcontrib><creatorcontrib>Feeley, T. M.</creatorcontrib><creatorcontrib>Egan, B.</creatorcontrib><creatorcontrib>O'Neill, D.</creatorcontrib><creatorcontrib>Collins, R. D.</creatorcontrib><creatorcontrib>Coughlan, T.</creatorcontrib><creatorcontrib>Harbison, J. A.</creatorcontrib><creatorcontrib>Doherty, C. P.</creatorcontrib><creatorcontrib>Madhavan, P.</creatorcontrib><creatorcontrib>Moore, D. J.</creatorcontrib><creatorcontrib>O'Neill, S. M.</creatorcontrib><creatorcontrib>Colgan, M.-P.</creatorcontrib><creatorcontrib>Saqqur, M.</creatorcontrib><creatorcontrib>Murphy, R. P.</creatorcontrib><creatorcontrib>Moran, N.</creatorcontrib><creatorcontrib>Hamilton, G.</creatorcontrib><creatorcontrib>McCabe, D. J. H.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kinsella, J. A.</au><au>Tobin, W. O.</au><au>Kavanagh, G. F.</au><au>O'Donnell, J. S.</au><au>McGrath, R. T.</au><au>Tierney, S.</au><au>Feeley, T. M.</au><au>Egan, B.</au><au>O'Neill, D.</au><au>Collins, R. D.</au><au>Coughlan, T.</au><au>Harbison, J. A.</au><au>Doherty, C. P.</au><au>Madhavan, P.</au><au>Moore, D. J.</au><au>O'Neill, S. M.</au><au>Colgan, M.-P.</au><au>Saqqur, M.</au><au>Murphy, R. P.</au><au>Moran, N.</au><au>Hamilton, G.</au><au>McCabe, D. J. H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased endothelial activation in recently symptomatic versus asymptomatic carotid artery stenosis and in cerebral microembolic-signal-negative patient subgroups</atitle><jtitle>European journal of neurology</jtitle><addtitle>Eur J Neurol</addtitle><date>2014-07</date><risdate>2014</risdate><volume>21</volume><issue>7</issue><spage>969</spage><epage>e55</epage><pages>969-e55</pages><issn>1351-5101</issn><eissn>1468-1331</eissn><coden>EJNEFL</coden><abstract>Background and purpose
von Willebrand factor propeptide (VWF:Ag II) is potentially a more sensitive marker of acute endothelial activation than von Willebrand factor antigen (VWF:Ag). These biomarkers have not been simultaneously assessed in asymptomatic versus symptomatic carotid stenosis patients. The relationship between endothelial activation and cerebral microembolic signals (MESs) detected on transcranial Doppler ultrasound is unknown.
Methods
In this multicentre observational analytical study, plasma VWF:Ag and VWF:Ag II levels in patients with ≥50% asymptomatic carotid stenosis were compared with those from patients with ≥50% symptomatic carotid stenosis in the ‘early’ (≤4 weeks) and ‘late’ (≥3 months) phases after transient ischaemic attack or ischaemic stroke. Endothelial activation was also longitudinally assessed in symptomatic patients during follow‐up. Transcranial Doppler ultrasound monitoring classified patients as MES‐positive or MES‐negative.
Results
Data from 31 asymptomatic patients were compared with those from 46 early symptomatic and 35 late phase symptomatic carotid stenosis patients, 23 of whom had undergone carotid intervention. VWF:Ag II levels were higher in early (12.8 μg/ml; P < 0.001), late (10.6 μg/ml; P = 0.01) and late post‐intervention (10.6 μg/ml; P = 0.038) symptomatic patients than asymptomatic patients (8.9 μg/ml). VWF:Ag levels decreased in symptomatic patients followed up from the early to late phase after symptom onset (P = 0.048). Early symptomatic MES‐negative patients had higher VWF: Ag II levels (13.3 vs. 9.0 μg/ml; P < 0.001) than asymptomatic MES‐negative patients.
Conclusions
Endothelial activation is enhanced in symptomatic versus asymptomatic carotid stenosis patients, in early symptomatic versus asymptomatic MES‐negative patients, and decreases over time in symptomatic patients. VWF:Ag II levels are a more sensitive marker of endothelial activation than VWF:Ag levels in carotid stenosis. The potential value of endothelial biomarkers and concurrent cerebral MES detection at predicting stroke risk in carotid stenosis warrants further study.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>24712648</pmid><doi>10.1111/ene.12403</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1351-5101 |
| ispartof | European journal of neurology, 2014-07, Vol.21 (7), p.969-e55 |
| issn | 1351-5101 1468-1331 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1544000462 |
| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Aged Angioplasty Biomarkers Biomarkers - blood Brain Ischemia - etiology carotid stenosis Carotid Stenosis - blood Carotid Stenosis - complications Carotid Stenosis - diagnostic imaging cerebral microemboli Endothelium - metabolism Endothelium - secretion Humans Intracranial Embolism - blood Intracranial Embolism - diagnostic imaging Ischemic Attack, Transient - etiology Male Middle Aged Older people stroke Stroke - etiology transient ischaemic attack Ultrasonography von Willebrand Factor |
| title | Increased endothelial activation in recently symptomatic versus asymptomatic carotid artery stenosis and in cerebral microembolic-signal-negative patient subgroups |
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