Brain gene expression patterns differentiate mild cognitive impairment from normal aged and Alzheimer's disease

Abstract Mild cognitive impairment (MCI) represents a cognitive state intermediate between normal aging and early Alzheimer's disease (AD). To investigate if the molecular signature of MCI parallels the clinical picture, we use microarrays to extensively profile gene expression in 4 cortical br...

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Veröffentlicht in:	Neurobiology of aging 2014-09, Vol.35 (9), p.1961-1972
Hauptverfasser:	Berchtold, Nicole C, Sabbagh, Marwan N, Beach, Thomas G, Kim, Ronald C, Cribbs, David H, Cotman, Carl W
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Aging - genetics Aging - metabolism Aging - pathology Aging - psychology Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer Disease - psychology Brain - metabolism Brain - pathology Brain - physiopathology Cognitive Dysfunction - genetics Cognitive Dysfunction - metabolism Cognitive Dysfunction - pathology Cognitive Dysfunction - psychology Electron transport Energy Metabolism - genetics Entorhinal cortex Female Gene Expression - genetics Gene Expression Profiling Hippocampus Humans Internal Medicine Male Metabolism - genetics Microarray Microarray Analysis Mitochondria Mitochondria - genetics Mitochondria - metabolism Myelin Sheath - metabolism Neurology Neuronal Plasticity - genetics Neuropsychological Tests Neurotransmitter receptor Protein Biosynthesis - genetics Protein Transport - genetics SNARE Somatosensory cortex Superior frontal gyrus Synapse Synaptic Transmission - genetics Transcription, Genetic - genetics
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