The therapeutic potential of a novel PSMA antibody and its IL-2 conjugate in prostate cancer

Prostate-specific membrane antigen (PSMA) is an attractive target for treatment of prostate cancer. Using the PSMA-recognizing mouse monoclonal antibody 2C9 obtained in our previous study, the biological activities of PSMA antibody were evaluated. Mouse-human chimeric IgG1 of 2C9 (KM2777) showed ant...

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Veröffentlicht in:	Anticancer research 2014-01, Vol.34 (1), p.89-97
Hauptverfasser:	Sugimoto, Yoshiyuki, Hirota, Maiko, Yoshikawa, Kazuhiro, Sumitomo, Makoto, Nakamura, Kogenta, Ueda, Ryuzo, Niwa, Rinpei, Suzawa, Toshiyuki, Yamasaki, Motoo, Shitara, Kenya, Kato, Takashi, Nakamura, Kazuyasu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - therapeutic use Antibody-Dependent Cell Cytotoxicity Antigens, Surface - immunology Cytotoxicity, Immunologic - immunology Flow Cytometry Glutamate Carboxypeptidase II - antagonists & inhibitors Glutamate Carboxypeptidase II - immunology Humans Interleukin-2 - immunology Interleukin-2 - metabolism Leukocytes, Mononuclear Male Membrane Glycoproteins - antagonists & inhibitors Membrane Glycoproteins - immunology Mice Mice, SCID Prostatic Neoplasms - immunology Prostatic Neoplasms - pathology Prostatic Neoplasms - therapy T-Lymphocytes Tumor Cells, Cultured Xenograft Model Antitumor Assays
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