Montreal Cognitive Assessment Memory Index Score (MoCA-MIS) as a Predictor of Conversion from Mild Cognitive Impairment to Alzheimer's Disease
Objectives To assess the usefulness of the Montreal Cognitive Assessment (MoCA) total score (MoCA‐TS) and Memory Index Score (MoCA‐MIS) in predicting conversion to Alzheimer's disease (AD) in individuals with mild cognitive impairment (MCI). Design Retrospective chart review. Setting Community‐...
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| Veröffentlicht in: | Journal of the American Geriatrics Society (JAGS) 2014-04, Vol.62 (4), p.679-684 |
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| container_title | Journal of the American Geriatrics Society (JAGS) |
| container_volume | 62 |
| creator | Julayanont, Parunyou Brousseau, Mélanie Chertkow, Howard Phillips, Natalie Nasreddine, Ziad S. |
| description | Objectives
To assess the usefulness of the Montreal Cognitive Assessment (MoCA) total score (MoCA‐TS) and Memory Index Score (MoCA‐MIS) in predicting conversion to Alzheimer's disease (AD) in individuals with mild cognitive impairment (MCI).
Design
Retrospective chart review.
Setting
Community‐based memory clinic.
Participants
Individuals meeting Petersen's MCI criteria (N = 165).
Measurements
Baseline MoCA scores at MCI diagnosis were collected from charts of eligible individuals with MCI, and MoCA‐TS, MoCA‐MIS, and a cognitive domain index score were calculated to assess their prognostic value in predicting conversion to AD.
Results
One hundred fourteen participants progressed to AD (MCI‐AD), and 51 did not (nonconverters; MCI‐NC); 90.5% of participants with MCI with a MoCA‐TS less than 20/30 and a MoCA‐MIS less than 7/15 at baseline converted to AD within the average follow‐up period of 18 months, compared with 52.7% of participants with MCI above the cutoffs on both scores. Individuals with multiple‐domain amnestic MCI had the highest AD conversion rates (73.9%).
Conclusion
Identifying individuals with MCI at high risk of conversion to AD is important clinically and for selecting appropriate subjects for therapeutic trials. Individuals with MCI with a low MoCA‐TS and a low newly devised memory index score (MoCA‐MIS) are at greater risk of short‐term conversion to AD. |
| doi_str_mv | 10.1111/jgs.12742 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1543998833</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3274428661</sourcerecordid><originalsourceid>FETCH-LOGICAL-i4462-a9aec79ca790f8c11420bd57a2e996905a1f8a57cf1ce5eef47b7a8e5e45001f3</originalsourceid><addsrcrecordid>eNqN0s1uEzEQB3ALgWgoHHgBZAkhymFbf67tY5RCCOpCpIA4Ws7ubHHYXQd7Uxoegmdm80FBnPDFI_k3f2nkQegpJed0OBer63ROmRLsHhpRyVkmBZX30YgQwjKdU3GCHqW0IoQyovVDdMJEziUhYoR-FqHrI7gGT8J153t_A3icEqTUQtfjAtoQt3jWVXCLF2WIgM-KMBlnxWzxCruEHZ5HqHzZh4hDPYR0NxCTDx2uY2hx4Zvqr-RZu3Y-7pP7gMfNjy_gW4gvE770CVyCx-hB7ZoET473Kfr05vXHydvs6sN0NhlfZV6InGXOOCiVKZ0ypNYlpYKRZSWVY2BMboh0tNZOqrKmJUiAWqilcnooxTA2rfkpOjvkrmP4toHU29anEprGdRA2yVIpuDFac_4flOaKyZyxgT7_h67CJnbDIDslcyOM3qlnR7VZtlDZdfSti1v7-1MG8OIIXCpdU0fXlT79cVooybUZ3MXBffcNbO_eKbG7rbDDVtj9Vth308W-GDqyQ4dPPdzedbj41eaKK2k_v59aouaUT_mlnfNfw_e3GQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1515694982</pqid></control><display><type>article</type><title>Montreal Cognitive Assessment Memory Index Score (MoCA-MIS) as a Predictor of Conversion from Mild Cognitive Impairment to Alzheimer's Disease</title><source>Access via Wiley Online Library</source><source>MEDLINE</source><creator>Julayanont, Parunyou ; Brousseau, Mélanie ; Chertkow, Howard ; Phillips, Natalie ; Nasreddine, Ziad S.</creator><creatorcontrib>Julayanont, Parunyou ; Brousseau, Mélanie ; Chertkow, Howard ; Phillips, Natalie ; Nasreddine, Ziad S.</creatorcontrib><description>Objectives
To assess the usefulness of the Montreal Cognitive Assessment (MoCA) total score (MoCA‐TS) and Memory Index Score (MoCA‐MIS) in predicting conversion to Alzheimer's disease (AD) in individuals with mild cognitive impairment (MCI).
Design
Retrospective chart review.
Setting
Community‐based memory clinic.
Participants
Individuals meeting Petersen's MCI criteria (N = 165).
Measurements
Baseline MoCA scores at MCI diagnosis were collected from charts of eligible individuals with MCI, and MoCA‐TS, MoCA‐MIS, and a cognitive domain index score were calculated to assess their prognostic value in predicting conversion to AD.
Results
One hundred fourteen participants progressed to AD (MCI‐AD), and 51 did not (nonconverters; MCI‐NC); 90.5% of participants with MCI with a MoCA‐TS less than 20/30 and a MoCA‐MIS less than 7/15 at baseline converted to AD within the average follow‐up period of 18 months, compared with 52.7% of participants with MCI above the cutoffs on both scores. Individuals with multiple‐domain amnestic MCI had the highest AD conversion rates (73.9%).
Conclusion
Identifying individuals with MCI at high risk of conversion to AD is important clinically and for selecting appropriate subjects for therapeutic trials. Individuals with MCI with a low MoCA‐TS and a low newly devised memory index score (MoCA‐MIS) are at greater risk of short‐term conversion to AD.</description><identifier>ISSN: 0002-8614</identifier><identifier>EISSN: 1532-5415</identifier><identifier>DOI: 10.1111/jgs.12742</identifier><identifier>PMID: 24635004</identifier><identifier>CODEN: JAGSAF</identifier><language>eng</language><publisher>Hoboken, NJ: Blackwell Publishing Ltd</publisher><subject>Aged ; Alzheimer ; Alzheimer Disease - diagnosis ; Alzheimer Disease - epidemiology ; Alzheimer Disease - psychology ; Alzheimer's disease ; Biological and medical sciences ; Cognition - physiology ; Cognitive ability ; Cognitive Dysfunction - diagnosis ; Cognitive Dysfunction - epidemiology ; Cognitive Dysfunction - psychology ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Disease Progression ; Female ; Follow-Up Studies ; General aspects ; Geriatric Assessment - methods ; Geriatrics ; Humans ; Incidence ; Magnetic Resonance Imaging ; Male ; Measurement ; Medical prognosis ; Medical sciences ; Memory - physiology ; Memory Index Score ; mild cognitive impairment ; Montreal Cognitive Assessment ; Neurology ; Neuropsychological Tests ; Predictive Value of Tests ; Prognosis ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Quebec - epidemiology ; Retrospective Studies ; Surveys and Questionnaires ; Tomography, X-Ray Computed</subject><ispartof>Journal of the American Geriatrics Society (JAGS), 2014-04, Vol.62 (4), p.679-684</ispartof><rights>2014, Copyright the Authors Journal compilation © 2014, The American Geriatrics Society</rights><rights>2015 INIST-CNRS</rights><rights>2014, Copyright the Authors Journal compilation © 2014, The American Geriatrics Society.</rights><rights>2014 American Geriatrics Society and Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjgs.12742$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjgs.12742$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28475389$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24635004$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Julayanont, Parunyou</creatorcontrib><creatorcontrib>Brousseau, Mélanie</creatorcontrib><creatorcontrib>Chertkow, Howard</creatorcontrib><creatorcontrib>Phillips, Natalie</creatorcontrib><creatorcontrib>Nasreddine, Ziad S.</creatorcontrib><title>Montreal Cognitive Assessment Memory Index Score (MoCA-MIS) as a Predictor of Conversion from Mild Cognitive Impairment to Alzheimer's Disease</title><title>Journal of the American Geriatrics Society (JAGS)</title><addtitle>J Am Geriatr Soc</addtitle><description>Objectives
To assess the usefulness of the Montreal Cognitive Assessment (MoCA) total score (MoCA‐TS) and Memory Index Score (MoCA‐MIS) in predicting conversion to Alzheimer's disease (AD) in individuals with mild cognitive impairment (MCI).
Design
Retrospective chart review.
Setting
Community‐based memory clinic.
Participants
Individuals meeting Petersen's MCI criteria (N = 165).
Measurements
Baseline MoCA scores at MCI diagnosis were collected from charts of eligible individuals with MCI, and MoCA‐TS, MoCA‐MIS, and a cognitive domain index score were calculated to assess their prognostic value in predicting conversion to AD.
Results
One hundred fourteen participants progressed to AD (MCI‐AD), and 51 did not (nonconverters; MCI‐NC); 90.5% of participants with MCI with a MoCA‐TS less than 20/30 and a MoCA‐MIS less than 7/15 at baseline converted to AD within the average follow‐up period of 18 months, compared with 52.7% of participants with MCI above the cutoffs on both scores. Individuals with multiple‐domain amnestic MCI had the highest AD conversion rates (73.9%).
Conclusion
Identifying individuals with MCI at high risk of conversion to AD is important clinically and for selecting appropriate subjects for therapeutic trials. Individuals with MCI with a low MoCA‐TS and a low newly devised memory index score (MoCA‐MIS) are at greater risk of short‐term conversion to AD.</description><subject>Aged</subject><subject>Alzheimer</subject><subject>Alzheimer Disease - diagnosis</subject><subject>Alzheimer Disease - epidemiology</subject><subject>Alzheimer Disease - psychology</subject><subject>Alzheimer's disease</subject><subject>Biological and medical sciences</subject><subject>Cognition - physiology</subject><subject>Cognitive ability</subject><subject>Cognitive Dysfunction - diagnosis</subject><subject>Cognitive Dysfunction - epidemiology</subject><subject>Cognitive Dysfunction - psychology</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>General aspects</subject><subject>Geriatric Assessment - methods</subject><subject>Geriatrics</subject><subject>Humans</subject><subject>Incidence</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Measurement</subject><subject>Medical prognosis</subject><subject>Medical sciences</subject><subject>Memory - physiology</subject><subject>Memory Index Score</subject><subject>mild cognitive impairment</subject><subject>Montreal Cognitive Assessment</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Quebec - epidemiology</subject><subject>Retrospective Studies</subject><subject>Surveys and Questionnaires</subject><subject>Tomography, X-Ray Computed</subject><issn>0002-8614</issn><issn>1532-5415</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0s1uEzEQB3ALgWgoHHgBZAkhymFbf67tY5RCCOpCpIA4Ws7ubHHYXQd7Uxoegmdm80FBnPDFI_k3f2nkQegpJed0OBer63ROmRLsHhpRyVkmBZX30YgQwjKdU3GCHqW0IoQyovVDdMJEziUhYoR-FqHrI7gGT8J153t_A3icEqTUQtfjAtoQt3jWVXCLF2WIgM-KMBlnxWzxCruEHZ5HqHzZh4hDPYR0NxCTDx2uY2hx4Zvqr-RZu3Y-7pP7gMfNjy_gW4gvE770CVyCx-hB7ZoET473Kfr05vXHydvs6sN0NhlfZV6InGXOOCiVKZ0ypNYlpYKRZSWVY2BMboh0tNZOqrKmJUiAWqilcnooxTA2rfkpOjvkrmP4toHU29anEprGdRA2yVIpuDFac_4flOaKyZyxgT7_h67CJnbDIDslcyOM3qlnR7VZtlDZdfSti1v7-1MG8OIIXCpdU0fXlT79cVooybUZ3MXBffcNbO_eKbG7rbDDVtj9Vth308W-GDqyQ4dPPdzedbj41eaKK2k_v59aouaUT_mlnfNfw_e3GQ</recordid><startdate>201404</startdate><enddate>201404</enddate><creator>Julayanont, Parunyou</creator><creator>Brousseau, Mélanie</creator><creator>Chertkow, Howard</creator><creator>Phillips, Natalie</creator><creator>Nasreddine, Ziad S.</creator><general>Blackwell Publishing Ltd</general><general>Wiley-Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>201404</creationdate><title>Montreal Cognitive Assessment Memory Index Score (MoCA-MIS) as a Predictor of Conversion from Mild Cognitive Impairment to Alzheimer's Disease</title><author>Julayanont, Parunyou ; Brousseau, Mélanie ; Chertkow, Howard ; Phillips, Natalie ; Nasreddine, Ziad S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i4462-a9aec79ca790f8c11420bd57a2e996905a1f8a57cf1ce5eef47b7a8e5e45001f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Alzheimer</topic><topic>Alzheimer Disease - diagnosis</topic><topic>Alzheimer Disease - epidemiology</topic><topic>Alzheimer Disease - psychology</topic><topic>Alzheimer's disease</topic><topic>Biological and medical sciences</topic><topic>Cognition - physiology</topic><topic>Cognitive ability</topic><topic>Cognitive Dysfunction - diagnosis</topic><topic>Cognitive Dysfunction - epidemiology</topic><topic>Cognitive Dysfunction - psychology</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>General aspects</topic><topic>Geriatric Assessment - methods</topic><topic>Geriatrics</topic><topic>Humans</topic><topic>Incidence</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Measurement</topic><topic>Medical prognosis</topic><topic>Medical sciences</topic><topic>Memory - physiology</topic><topic>Memory Index Score</topic><topic>mild cognitive impairment</topic><topic>Montreal Cognitive Assessment</topic><topic>Neurology</topic><topic>Neuropsychological Tests</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Quebec - epidemiology</topic><topic>Retrospective Studies</topic><topic>Surveys and Questionnaires</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Julayanont, Parunyou</creatorcontrib><creatorcontrib>Brousseau, Mélanie</creatorcontrib><creatorcontrib>Chertkow, Howard</creatorcontrib><creatorcontrib>Phillips, Natalie</creatorcontrib><creatorcontrib>Nasreddine, Ziad S.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Geriatrics Society (JAGS)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Julayanont, Parunyou</au><au>Brousseau, Mélanie</au><au>Chertkow, Howard</au><au>Phillips, Natalie</au><au>Nasreddine, Ziad S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Montreal Cognitive Assessment Memory Index Score (MoCA-MIS) as a Predictor of Conversion from Mild Cognitive Impairment to Alzheimer's Disease</atitle><jtitle>Journal of the American Geriatrics Society (JAGS)</jtitle><addtitle>J Am Geriatr Soc</addtitle><date>2014-04</date><risdate>2014</risdate><volume>62</volume><issue>4</issue><spage>679</spage><epage>684</epage><pages>679-684</pages><issn>0002-8614</issn><eissn>1532-5415</eissn><coden>JAGSAF</coden><abstract>Objectives
To assess the usefulness of the Montreal Cognitive Assessment (MoCA) total score (MoCA‐TS) and Memory Index Score (MoCA‐MIS) in predicting conversion to Alzheimer's disease (AD) in individuals with mild cognitive impairment (MCI).
Design
Retrospective chart review.
Setting
Community‐based memory clinic.
Participants
Individuals meeting Petersen's MCI criteria (N = 165).
Measurements
Baseline MoCA scores at MCI diagnosis were collected from charts of eligible individuals with MCI, and MoCA‐TS, MoCA‐MIS, and a cognitive domain index score were calculated to assess their prognostic value in predicting conversion to AD.
Results
One hundred fourteen participants progressed to AD (MCI‐AD), and 51 did not (nonconverters; MCI‐NC); 90.5% of participants with MCI with a MoCA‐TS less than 20/30 and a MoCA‐MIS less than 7/15 at baseline converted to AD within the average follow‐up period of 18 months, compared with 52.7% of participants with MCI above the cutoffs on both scores. Individuals with multiple‐domain amnestic MCI had the highest AD conversion rates (73.9%).
Conclusion
Identifying individuals with MCI at high risk of conversion to AD is important clinically and for selecting appropriate subjects for therapeutic trials. Individuals with MCI with a low MoCA‐TS and a low newly devised memory index score (MoCA‐MIS) are at greater risk of short‐term conversion to AD.</abstract><cop>Hoboken, NJ</cop><pub>Blackwell Publishing Ltd</pub><pmid>24635004</pmid><doi>10.1111/jgs.12742</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0002-8614 |
| ispartof | Journal of the American Geriatrics Society (JAGS), 2014-04, Vol.62 (4), p.679-684 |
| issn | 0002-8614 1532-5415 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1543998833 |
| source | Access via Wiley Online Library; MEDLINE |
| subjects | Aged Alzheimer Alzheimer Disease - diagnosis Alzheimer Disease - epidemiology Alzheimer Disease - psychology Alzheimer's disease Biological and medical sciences Cognition - physiology Cognitive ability Cognitive Dysfunction - diagnosis Cognitive Dysfunction - epidemiology Cognitive Dysfunction - psychology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Progression Female Follow-Up Studies General aspects Geriatric Assessment - methods Geriatrics Humans Incidence Magnetic Resonance Imaging Male Measurement Medical prognosis Medical sciences Memory - physiology Memory Index Score mild cognitive impairment Montreal Cognitive Assessment Neurology Neuropsychological Tests Predictive Value of Tests Prognosis Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Quebec - epidemiology Retrospective Studies Surveys and Questionnaires Tomography, X-Ray Computed |
| title | Montreal Cognitive Assessment Memory Index Score (MoCA-MIS) as a Predictor of Conversion from Mild Cognitive Impairment to Alzheimer's Disease |
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