Amorphous solid dispersions and nano-crystal technologies for poorly water-soluble drug delivery
Poor water-solubility is a common characteristic of drug candidates in pharmaceutical development pipelines today. Various processes have been developed to increase the solubility, dissolution rate and bioavailability of these active ingredients belonging to BCS II and IV classifications. Over the l...
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| Veröffentlicht in: | International journal of pharmaceutics 2013-08, Vol.453 (1), p.157-166 |
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| container_title | International journal of pharmaceutics |
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| creator | Brough, Chris Williams, R.O. |
| description | Poor water-solubility is a common characteristic of drug candidates in pharmaceutical development pipelines today. Various processes have been developed to increase the solubility, dissolution rate and bioavailability of these active ingredients belonging to BCS II and IV classifications. Over the last decade, nano-crystal delivery forms and amorphous solid dispersions have become well established in commercially available products and industry literature. This article is a comparative analysis of these two methodologies primarily for orally delivered medicaments. The thermodynamic and kinetic theories relative to these technologies are presented along with marketed product evaluations and a survey of commercial relevant scientific literature. |
| doi_str_mv | 10.1016/j.ijpharm.2013.05.061 |
| format | Article |
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| identifier | ISSN: 0378-5173 |
| ispartof | International journal of pharmaceutics, 2013-08, Vol.453 (1), p.157-166 |
| issn | 0378-5173 1873-3476 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | active ingredients Amorphous solid dispersions Animals bioavailability dispersions Drug Delivery Systems drugs Humans industry Nano-crystal nanocrystals Nanoparticles Nanoparticles - administration & dosage Nanoparticles - chemistry Pharmaceutical Preparations - administration & dosage Pharmaceutical Preparations - chemistry Pharmacokinetics pipelines Poorly water-soluble drugs product evaluation Solubility surveys thermodynamics Water - chemistry water solubility |
| title | Amorphous solid dispersions and nano-crystal technologies for poorly water-soluble drug delivery |
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