Fullerene derivatives as a new class of inhibitors of protein tyrosine phosphatases

In this study, we identified water-soluble C60 and C70 fullerene derivatives as a novel class of protein tyrosine phosphatase inhibitors. The evaluated compounds were found to inhibit CD45, PTP1B, TC-PTP, SHP2, and PTPβ with IC50 values in the low micromolar to high nanomolar range. These results de...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2014-07, Vol.24 (14), p.3175-3179
Hauptverfasser:	Kobzar, Oleksandr L., Trush, Viacheslav V., Tanchuk, Vsevolod Yu, Zhilenkov, Alexander V., Troshin, Pavel A., Vovk, Andriy I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Dose-Response Relationship, Drug Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Fullerene Fullerenes - chemistry Fullerenes - pharmacology Humans Inhibition Molecular Conformation Molecular docking Protein tyrosine phosphatase Protein Tyrosine Phosphatases - antagonists & inhibitors Protein Tyrosine Phosphatases - metabolism Structure-Activity Relationship
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