Enhancement of n-butanol production by in situ butanol removal using permeating–heating–gas stripping in acetone–butanol–ethanol fermentation
•Gas stripping model of ABE from model solutions was characterized.•Integrated fermentation system with gas stripping for in situ butanol recovery.•Fed-batch fermentation with solvent removal at 70°C has been demonstrated.•Permeating–heating–gas stripping greatly enhances butanol productivity and yi...
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| Veröffentlicht in: | Bioresource technology 2014-07, Vol.164, p.276-284 |
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| creator | Chen, Yong Ren, Hengfei Liu, Dong Zhao, Ting Shi, Xinchi Cheng, Hao Zhao, Nan Li, Zhenjian Li, Bingbing Niu, Huanqing Zhuang, Wei Xie, Jingjing Chen, Xiaochun Wu, Jinglan Ying, Hanjie |
| description | •Gas stripping model of ABE from model solutions was characterized.•Integrated fermentation system with gas stripping for in situ butanol recovery.•Fed-batch fermentation with solvent removal at 70°C has been demonstrated.•Permeating–heating–gas stripping greatly enhances butanol productivity and yield.
Butanol recovery from acetone–butanol–ethanol (ABE) fed-batch fermentation using permeating–heating–gas was determined in this study. Fermentation was performed with Clostridium acetobutylicum B3 in a fibrous bed bioreactor and permeating–heating–gas stripping was used to eliminate substrate and product inhibition, which normally restrict ABE production and sugar utilization to below 20g/L and 60g/L, respectively. In batch fermentation (without permeating–heating–gas stripping), C. acetobutylicum B3 utilized 60g/L glucose and produced 19.9g/L ABE and 12g/L butanol, while in the integrated process 290g/L glucose was utilized and 106.27g/L ABE and 66.09g/L butanol were produced. The intermittent gas stripping process generated a highly concentrated condensate containing approximately 15% (w/v) butanol, 4% (w/v) acetone, a small amount of ethanol ( |
| doi_str_mv | 10.1016/j.biortech.2014.04.107 |
| format | Article |
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Butanol recovery from acetone–butanol–ethanol (ABE) fed-batch fermentation using permeating–heating–gas was determined in this study. Fermentation was performed with Clostridium acetobutylicum B3 in a fibrous bed bioreactor and permeating–heating–gas stripping was used to eliminate substrate and product inhibition, which normally restrict ABE production and sugar utilization to below 20g/L and 60g/L, respectively. In batch fermentation (without permeating–heating–gas stripping), C. acetobutylicum B3 utilized 60g/L glucose and produced 19.9g/L ABE and 12g/L butanol, while in the integrated process 290g/L glucose was utilized and 106.27g/L ABE and 66.09g/L butanol were produced. The intermittent gas stripping process generated a highly concentrated condensate containing approximately 15% (w/v) butanol, 4% (w/v) acetone, a small amount of ethanol (<1%), and almost no acids, resulting in a highly concentrated butanol solution [∼70% (w/v)] after phase separation. Butanol removal by permeating–heating–gas stripping has potential for commercial ABE production.</description><identifier>ISSN: 0960-8524</identifier><identifier>EISSN: 1873-2976</identifier><identifier>DOI: 10.1016/j.biortech.2014.04.107</identifier><identifier>PMID: 24862004</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>1-Butanol - metabolism ; ABE fermentation ; Acetone ; Acetone - metabolism ; Batch Cell Culture Techniques ; Biological and medical sciences ; Biotechnology ; Biotechnology - methods ; Butanol ; Cell immobilization ; Clostridium acetobutylicum - metabolism ; Ethanol ; Ethanol - metabolism ; Ethyl alcohol ; Fed-batch fermentation ; Fermentation ; Fundamental and applied biological sciences. Psychology ; Gases - chemistry ; Glucose ; Heating ; Kinetics ; Methods. Procedures. Technologies ; Microbial engineering. Fermentation and microbial culture technology ; Models, Theoretical ; Permeating–heating–gas stripping ; Solutions ; Solvents - chemistry ; Stripping ; Substrate inhibition</subject><ispartof>Bioresource technology, 2014-07, Vol.164, p.276-284</ispartof><rights>2014 The Authors</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-4a483185b36fc8fea2498156ae4814f88fdbc526bee1b3f538e2c382e4d629643</citedby><cites>FETCH-LOGICAL-c431t-4a483185b36fc8fea2498156ae4814f88fdbc526bee1b3f538e2c382e4d629643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.biortech.2014.04.107$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28528366$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24862004$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Yong</creatorcontrib><creatorcontrib>Ren, Hengfei</creatorcontrib><creatorcontrib>Liu, Dong</creatorcontrib><creatorcontrib>Zhao, Ting</creatorcontrib><creatorcontrib>Shi, Xinchi</creatorcontrib><creatorcontrib>Cheng, Hao</creatorcontrib><creatorcontrib>Zhao, Nan</creatorcontrib><creatorcontrib>Li, Zhenjian</creatorcontrib><creatorcontrib>Li, Bingbing</creatorcontrib><creatorcontrib>Niu, Huanqing</creatorcontrib><creatorcontrib>Zhuang, Wei</creatorcontrib><creatorcontrib>Xie, Jingjing</creatorcontrib><creatorcontrib>Chen, Xiaochun</creatorcontrib><creatorcontrib>Wu, Jinglan</creatorcontrib><creatorcontrib>Ying, Hanjie</creatorcontrib><title>Enhancement of n-butanol production by in situ butanol removal using permeating–heating–gas stripping in acetone–butanol–ethanol fermentation</title><title>Bioresource technology</title><addtitle>Bioresour Technol</addtitle><description>•Gas stripping model of ABE from model solutions was characterized.•Integrated fermentation system with gas stripping for in situ butanol recovery.•Fed-batch fermentation with solvent removal at 70°C has been demonstrated.•Permeating–heating–gas stripping greatly enhances butanol productivity and yield.
Butanol recovery from acetone–butanol–ethanol (ABE) fed-batch fermentation using permeating–heating–gas was determined in this study. Fermentation was performed with Clostridium acetobutylicum B3 in a fibrous bed bioreactor and permeating–heating–gas stripping was used to eliminate substrate and product inhibition, which normally restrict ABE production and sugar utilization to below 20g/L and 60g/L, respectively. In batch fermentation (without permeating–heating–gas stripping), C. acetobutylicum B3 utilized 60g/L glucose and produced 19.9g/L ABE and 12g/L butanol, while in the integrated process 290g/L glucose was utilized and 106.27g/L ABE and 66.09g/L butanol were produced. The intermittent gas stripping process generated a highly concentrated condensate containing approximately 15% (w/v) butanol, 4% (w/v) acetone, a small amount of ethanol (<1%), and almost no acids, resulting in a highly concentrated butanol solution [∼70% (w/v)] after phase separation. Butanol removal by permeating–heating–gas stripping has potential for commercial ABE production.</description><subject>1-Butanol - metabolism</subject><subject>ABE fermentation</subject><subject>Acetone</subject><subject>Acetone - metabolism</subject><subject>Batch Cell Culture Techniques</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>Biotechnology - methods</subject><subject>Butanol</subject><subject>Cell immobilization</subject><subject>Clostridium acetobutylicum - metabolism</subject><subject>Ethanol</subject><subject>Ethanol - metabolism</subject><subject>Ethyl alcohol</subject><subject>Fed-batch fermentation</subject><subject>Fermentation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gases - chemistry</subject><subject>Glucose</subject><subject>Heating</subject><subject>Kinetics</subject><subject>Methods. Procedures. Technologies</subject><subject>Microbial engineering. Fermentation and microbial culture technology</subject><subject>Models, Theoretical</subject><subject>Permeating–heating–gas stripping</subject><subject>Solutions</subject><subject>Solvents - chemistry</subject><subject>Stripping</subject><subject>Substrate inhibition</subject><issn>0960-8524</issn><issn>1873-2976</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1u1DAURi0EokPhFSpvkNhk8F8cZweqSkGqxAbWluNcdzxKnGA7lbrrOyBekCepw8yUJax85Xv8XdsHoQtKtpRQ-X6_7fwUM9jdlhEqtkSU_eYZ2lDV8Iq1jXyONqSVpFI1E2foVUp7QginDXuJzphQkhEiNujXVdiZYGGEkPHkcKi6JZswDXiOU7_Y7KeAu3vsA04-L_jUjTBOd2bAS_LhFs8QRzC5lL8ffu6eqluTcMrRz_MKlQhjIU8BSuuYUyrIuz-Jbs0I2awTX6MXzgwJ3hzXc_T909W3y8_VzdfrL5cfbyorOM2VMEJxquqOS2eVA8NEq2gtDQhFhVPK9Z2tmewAaMddzRUwyxUD0UvWSsHP0btDbnnsjwVS1qNPFobBBJiWpGkteNs2nDf_gXLRtJLXqqDygNo4pRTB6Tn60cR7TYle7em9PtnTqz1NRNlfZ1wcZyzdCP3TsZOuArw9AiZZM7hY1Pn0lyuuFZeycB8OHJTPu_MQdbIeiubeR7BZ95P_110eAR7ew1Q</recordid><startdate>20140701</startdate><enddate>20140701</enddate><creator>Chen, Yong</creator><creator>Ren, Hengfei</creator><creator>Liu, Dong</creator><creator>Zhao, Ting</creator><creator>Shi, Xinchi</creator><creator>Cheng, Hao</creator><creator>Zhao, Nan</creator><creator>Li, Zhenjian</creator><creator>Li, Bingbing</creator><creator>Niu, Huanqing</creator><creator>Zhuang, Wei</creator><creator>Xie, Jingjing</creator><creator>Chen, Xiaochun</creator><creator>Wu, Jinglan</creator><creator>Ying, Hanjie</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7SU</scope><scope>7TB</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>KR7</scope></search><sort><creationdate>20140701</creationdate><title>Enhancement of n-butanol production by in situ butanol removal using permeating–heating–gas stripping in acetone–butanol–ethanol fermentation</title><author>Chen, Yong ; Ren, Hengfei ; Liu, Dong ; Zhao, Ting ; Shi, Xinchi ; Cheng, Hao ; Zhao, Nan ; Li, Zhenjian ; Li, Bingbing ; Niu, Huanqing ; Zhuang, Wei ; Xie, Jingjing ; Chen, Xiaochun ; Wu, Jinglan ; Ying, Hanjie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-4a483185b36fc8fea2498156ae4814f88fdbc526bee1b3f538e2c382e4d629643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>1-Butanol - metabolism</topic><topic>ABE fermentation</topic><topic>Acetone</topic><topic>Acetone - metabolism</topic><topic>Batch Cell Culture Techniques</topic><topic>Biological and medical sciences</topic><topic>Biotechnology</topic><topic>Biotechnology - methods</topic><topic>Butanol</topic><topic>Cell immobilization</topic><topic>Clostridium acetobutylicum - metabolism</topic><topic>Ethanol</topic><topic>Ethanol - metabolism</topic><topic>Ethyl alcohol</topic><topic>Fed-batch fermentation</topic><topic>Fermentation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gases - chemistry</topic><topic>Glucose</topic><topic>Heating</topic><topic>Kinetics</topic><topic>Methods. Procedures. Technologies</topic><topic>Microbial engineering. Fermentation and microbial culture technology</topic><topic>Models, Theoretical</topic><topic>Permeating–heating–gas stripping</topic><topic>Solutions</topic><topic>Solvents - chemistry</topic><topic>Stripping</topic><topic>Substrate inhibition</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Yong</creatorcontrib><creatorcontrib>Ren, Hengfei</creatorcontrib><creatorcontrib>Liu, Dong</creatorcontrib><creatorcontrib>Zhao, Ting</creatorcontrib><creatorcontrib>Shi, Xinchi</creatorcontrib><creatorcontrib>Cheng, Hao</creatorcontrib><creatorcontrib>Zhao, Nan</creatorcontrib><creatorcontrib>Li, Zhenjian</creatorcontrib><creatorcontrib>Li, Bingbing</creatorcontrib><creatorcontrib>Niu, Huanqing</creatorcontrib><creatorcontrib>Zhuang, Wei</creatorcontrib><creatorcontrib>Xie, Jingjing</creatorcontrib><creatorcontrib>Chen, Xiaochun</creatorcontrib><creatorcontrib>Wu, Jinglan</creatorcontrib><creatorcontrib>Ying, Hanjie</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Environmental Engineering Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Civil Engineering Abstracts</collection><jtitle>Bioresource technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Yong</au><au>Ren, Hengfei</au><au>Liu, Dong</au><au>Zhao, Ting</au><au>Shi, Xinchi</au><au>Cheng, Hao</au><au>Zhao, Nan</au><au>Li, Zhenjian</au><au>Li, Bingbing</au><au>Niu, Huanqing</au><au>Zhuang, Wei</au><au>Xie, Jingjing</au><au>Chen, Xiaochun</au><au>Wu, Jinglan</au><au>Ying, Hanjie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhancement of n-butanol production by in situ butanol removal using permeating–heating–gas stripping in acetone–butanol–ethanol fermentation</atitle><jtitle>Bioresource technology</jtitle><addtitle>Bioresour Technol</addtitle><date>2014-07-01</date><risdate>2014</risdate><volume>164</volume><spage>276</spage><epage>284</epage><pages>276-284</pages><issn>0960-8524</issn><eissn>1873-2976</eissn><abstract>•Gas stripping model of ABE from model solutions was characterized.•Integrated fermentation system with gas stripping for in situ butanol recovery.•Fed-batch fermentation with solvent removal at 70°C has been demonstrated.•Permeating–heating–gas stripping greatly enhances butanol productivity and yield.
Butanol recovery from acetone–butanol–ethanol (ABE) fed-batch fermentation using permeating–heating–gas was determined in this study. Fermentation was performed with Clostridium acetobutylicum B3 in a fibrous bed bioreactor and permeating–heating–gas stripping was used to eliminate substrate and product inhibition, which normally restrict ABE production and sugar utilization to below 20g/L and 60g/L, respectively. In batch fermentation (without permeating–heating–gas stripping), C. acetobutylicum B3 utilized 60g/L glucose and produced 19.9g/L ABE and 12g/L butanol, while in the integrated process 290g/L glucose was utilized and 106.27g/L ABE and 66.09g/L butanol were produced. The intermittent gas stripping process generated a highly concentrated condensate containing approximately 15% (w/v) butanol, 4% (w/v) acetone, a small amount of ethanol (<1%), and almost no acids, resulting in a highly concentrated butanol solution [∼70% (w/v)] after phase separation. Butanol removal by permeating–heating–gas stripping has potential for commercial ABE production.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>24862004</pmid><doi>10.1016/j.biortech.2014.04.107</doi><tpages>9</tpages></addata></record> |
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| subjects | 1-Butanol - metabolism ABE fermentation Acetone Acetone - metabolism Batch Cell Culture Techniques Biological and medical sciences Biotechnology Biotechnology - methods Butanol Cell immobilization Clostridium acetobutylicum - metabolism Ethanol Ethanol - metabolism Ethyl alcohol Fed-batch fermentation Fermentation Fundamental and applied biological sciences. Psychology Gases - chemistry Glucose Heating Kinetics Methods. Procedures. Technologies Microbial engineering. Fermentation and microbial culture technology Models, Theoretical Permeating–heating–gas stripping Solutions Solvents - chemistry Stripping Substrate inhibition |
| title | Enhancement of n-butanol production by in situ butanol removal using permeating–heating–gas stripping in acetone–butanol–ethanol fermentation |
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