Decrease in TSH levels after lactose restriction in Hashimoto’s thyroiditis patients with lactose intolerance
We aimed to evaluate the prevalence of lactose intolerance (LI) in patients with Hashimoto’s thyroiditis (HT) and the effects of lactose restriction on thyroid function in these patients. Eighty-three HT patients taking l -thyroxine (LT4) were enrolled, and lactose tolerance tests were performed on...
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| Veröffentlicht in: | Endocrine 2014-06, Vol.46 (2), p.279-284 |
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| creator | Asik, Mehmet Gunes, Fahri Binnetoglu, Emine Eroglu, Mustafa Bozkurt, Neslihan Sen, Hacer Akbal, Erdem Bakar, Coskun Beyazit, Yavuz Ukinc, Kubilay |
| description | We aimed to evaluate the prevalence of lactose intolerance (LI) in patients with Hashimoto’s thyroiditis (HT) and the effects of lactose restriction on thyroid function in these patients. Eighty-three HT patients taking
l
-thyroxine (LT4) were enrolled, and lactose tolerance tests were performed on all patients. Lactose intolerance was diagnosed in 75.9 % of the patients with HT. Thirty-eight patients with LI were started on a lactose-restricted diet for 8 weeks. Thirty-eight patients with LI (30 euthyroid and 8 with subclinical hypothyroidism), and 12 patients without LI were included in the final analysis. The level of TSH significantly decreased in the euthyroid and subclinical hypothyroid patients with LI [from 2.06 ± 1.02 to 1.51 ± 1.1 IU/mL and from 5.45 ± 0.74 to 2.25 ± 1.88 IU/mL, respectively (both
P
0.05). Lactose intolerance occurs at a high frequency in HT patients. Lactose restriction leads to decreased levels of TSH, and LI should be considered in hypothyroid patients who require increasing LT4 doses, have irregular TSH levels and are resistant to LT4 treatment. |
| doi_str_mv | 10.1007/s12020-013-0065-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1543995244</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1543995244</sourcerecordid><originalsourceid>FETCH-LOGICAL-c344t-5dbe1ce30d2e967e7d2f656121153adea4cb75bac17dfcb9f85bd078ccc27c7a3</originalsourceid><addsrcrecordid>eNp9kE1OwzAQhS0EoqVwADYoSzYBjxPHzRKVnyJVYkGR2FmOM6Gu0rjYLqg7rsH1OAmuWrpkNda87z15HiHnQK-AUnHtgVFGUwpZSmnBUzggfeC8jBtKD-M74zwqw9ceOfF-TiljrBDHpMdyKoY5QJ_YW9QOlcfEdMn0eZy0-IGtT1QT0CWt0sFGzaEPzuhgbLfhxsrPzMIG-_P17ZMwWztrahOMT5YqGOyCTz5NmO3tpgu2Rac6jafkqFGtx7PdHJCX-7vpaJxOnh4eRzeTVGd5HlJeVwgaM1ozLAuBomZNwQtgADxTNapcV4JXSoOoG12VzZBXdbxJa82EFiobkMtt7tLZ91X8vlwYr7FtVYd25SXwPCtLzvI8orBFtbPeO2zk0pmFcmsJVG56ltueZexZbnqWED0Xu_hVtcB67_grNgJsC_godW_o5NyuXBdP_if1F46bjCQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1543995244</pqid></control><display><type>article</type><title>Decrease in TSH levels after lactose restriction in Hashimoto’s thyroiditis patients with lactose intolerance</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Asik, Mehmet ; Gunes, Fahri ; Binnetoglu, Emine ; Eroglu, Mustafa ; Bozkurt, Neslihan ; Sen, Hacer ; Akbal, Erdem ; Bakar, Coskun ; Beyazit, Yavuz ; Ukinc, Kubilay</creator><creatorcontrib>Asik, Mehmet ; Gunes, Fahri ; Binnetoglu, Emine ; Eroglu, Mustafa ; Bozkurt, Neslihan ; Sen, Hacer ; Akbal, Erdem ; Bakar, Coskun ; Beyazit, Yavuz ; Ukinc, Kubilay</creatorcontrib><description>We aimed to evaluate the prevalence of lactose intolerance (LI) in patients with Hashimoto’s thyroiditis (HT) and the effects of lactose restriction on thyroid function in these patients. Eighty-three HT patients taking
l
-thyroxine (LT4) were enrolled, and lactose tolerance tests were performed on all patients. Lactose intolerance was diagnosed in 75.9 % of the patients with HT. Thirty-eight patients with LI were started on a lactose-restricted diet for 8 weeks. Thirty-eight patients with LI (30 euthyroid and 8 with subclinical hypothyroidism), and 12 patients without LI were included in the final analysis. The level of TSH significantly decreased in the euthyroid and subclinical hypothyroid patients with LI [from 2.06 ± 1.02 to 1.51 ± 1.1 IU/mL and from 5.45 ± 0.74 to 2.25 ± 1.88 IU/mL, respectively (both
P
< 0.05)]. However, the level of TSH in patients without LI did not change significantly over the 8 weeks (
P
> 0.05). Lactose intolerance occurs at a high frequency in HT patients. Lactose restriction leads to decreased levels of TSH, and LI should be considered in hypothyroid patients who require increasing LT4 doses, have irregular TSH levels and are resistant to LT4 treatment.</description><identifier>ISSN: 1355-008X</identifier><identifier>EISSN: 1559-0100</identifier><identifier>DOI: 10.1007/s12020-013-0065-1</identifier><identifier>PMID: 24078411</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adult ; Diabetes ; Diet ; Endocrinology ; Female ; Hashimoto Disease - blood ; Hashimoto Disease - complications ; Humanities and Social Sciences ; Humans ; Internal Medicine ; Lactose Intolerance - blood ; Lactose Intolerance - complications ; Lactose Intolerance - diet therapy ; Lactose Tolerance Test ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; multidisciplinary ; Original Article ; Science ; Thyrotropin - blood ; Treatment Outcome</subject><ispartof>Endocrine, 2014-06, Vol.46 (2), p.279-284</ispartof><rights>Springer Science+Business Media New York 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-5dbe1ce30d2e967e7d2f656121153adea4cb75bac17dfcb9f85bd078ccc27c7a3</citedby><cites>FETCH-LOGICAL-c344t-5dbe1ce30d2e967e7d2f656121153adea4cb75bac17dfcb9f85bd078ccc27c7a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12020-013-0065-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12020-013-0065-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24078411$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Asik, Mehmet</creatorcontrib><creatorcontrib>Gunes, Fahri</creatorcontrib><creatorcontrib>Binnetoglu, Emine</creatorcontrib><creatorcontrib>Eroglu, Mustafa</creatorcontrib><creatorcontrib>Bozkurt, Neslihan</creatorcontrib><creatorcontrib>Sen, Hacer</creatorcontrib><creatorcontrib>Akbal, Erdem</creatorcontrib><creatorcontrib>Bakar, Coskun</creatorcontrib><creatorcontrib>Beyazit, Yavuz</creatorcontrib><creatorcontrib>Ukinc, Kubilay</creatorcontrib><title>Decrease in TSH levels after lactose restriction in Hashimoto’s thyroiditis patients with lactose intolerance</title><title>Endocrine</title><addtitle>Endocrine</addtitle><addtitle>Endocrine</addtitle><description>We aimed to evaluate the prevalence of lactose intolerance (LI) in patients with Hashimoto’s thyroiditis (HT) and the effects of lactose restriction on thyroid function in these patients. Eighty-three HT patients taking
l
-thyroxine (LT4) were enrolled, and lactose tolerance tests were performed on all patients. Lactose intolerance was diagnosed in 75.9 % of the patients with HT. Thirty-eight patients with LI were started on a lactose-restricted diet for 8 weeks. Thirty-eight patients with LI (30 euthyroid and 8 with subclinical hypothyroidism), and 12 patients without LI were included in the final analysis. The level of TSH significantly decreased in the euthyroid and subclinical hypothyroid patients with LI [from 2.06 ± 1.02 to 1.51 ± 1.1 IU/mL and from 5.45 ± 0.74 to 2.25 ± 1.88 IU/mL, respectively (both
P
< 0.05)]. However, the level of TSH in patients without LI did not change significantly over the 8 weeks (
P
> 0.05). Lactose intolerance occurs at a high frequency in HT patients. Lactose restriction leads to decreased levels of TSH, and LI should be considered in hypothyroid patients who require increasing LT4 doses, have irregular TSH levels and are resistant to LT4 treatment.</description><subject>Adult</subject><subject>Diabetes</subject><subject>Diet</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Hashimoto Disease - blood</subject><subject>Hashimoto Disease - complications</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Lactose Intolerance - blood</subject><subject>Lactose Intolerance - complications</subject><subject>Lactose Intolerance - diet therapy</subject><subject>Lactose Tolerance Test</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Original Article</subject><subject>Science</subject><subject>Thyrotropin - blood</subject><subject>Treatment Outcome</subject><issn>1355-008X</issn><issn>1559-0100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1OwzAQhS0EoqVwADYoSzYBjxPHzRKVnyJVYkGR2FmOM6Gu0rjYLqg7rsH1OAmuWrpkNda87z15HiHnQK-AUnHtgVFGUwpZSmnBUzggfeC8jBtKD-M74zwqw9ceOfF-TiljrBDHpMdyKoY5QJ_YW9QOlcfEdMn0eZy0-IGtT1QT0CWt0sFGzaEPzuhgbLfhxsrPzMIG-_P17ZMwWztrahOMT5YqGOyCTz5NmO3tpgu2Rac6jafkqFGtx7PdHJCX-7vpaJxOnh4eRzeTVGd5HlJeVwgaM1ozLAuBomZNwQtgADxTNapcV4JXSoOoG12VzZBXdbxJa82EFiobkMtt7tLZ91X8vlwYr7FtVYd25SXwPCtLzvI8orBFtbPeO2zk0pmFcmsJVG56ltueZexZbnqWED0Xu_hVtcB67_grNgJsC_godW_o5NyuXBdP_if1F46bjCQ</recordid><startdate>20140601</startdate><enddate>20140601</enddate><creator>Asik, Mehmet</creator><creator>Gunes, Fahri</creator><creator>Binnetoglu, Emine</creator><creator>Eroglu, Mustafa</creator><creator>Bozkurt, Neslihan</creator><creator>Sen, Hacer</creator><creator>Akbal, Erdem</creator><creator>Bakar, Coskun</creator><creator>Beyazit, Yavuz</creator><creator>Ukinc, Kubilay</creator><general>Springer US</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140601</creationdate><title>Decrease in TSH levels after lactose restriction in Hashimoto’s thyroiditis patients with lactose intolerance</title><author>Asik, Mehmet ; Gunes, Fahri ; Binnetoglu, Emine ; Eroglu, Mustafa ; Bozkurt, Neslihan ; Sen, Hacer ; Akbal, Erdem ; Bakar, Coskun ; Beyazit, Yavuz ; Ukinc, Kubilay</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-5dbe1ce30d2e967e7d2f656121153adea4cb75bac17dfcb9f85bd078ccc27c7a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Diabetes</topic><topic>Diet</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Hashimoto Disease - blood</topic><topic>Hashimoto Disease - complications</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Lactose Intolerance - blood</topic><topic>Lactose Intolerance - complications</topic><topic>Lactose Intolerance - diet therapy</topic><topic>Lactose Tolerance Test</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>multidisciplinary</topic><topic>Original Article</topic><topic>Science</topic><topic>Thyrotropin - blood</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Asik, Mehmet</creatorcontrib><creatorcontrib>Gunes, Fahri</creatorcontrib><creatorcontrib>Binnetoglu, Emine</creatorcontrib><creatorcontrib>Eroglu, Mustafa</creatorcontrib><creatorcontrib>Bozkurt, Neslihan</creatorcontrib><creatorcontrib>Sen, Hacer</creatorcontrib><creatorcontrib>Akbal, Erdem</creatorcontrib><creatorcontrib>Bakar, Coskun</creatorcontrib><creatorcontrib>Beyazit, Yavuz</creatorcontrib><creatorcontrib>Ukinc, Kubilay</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Endocrine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Asik, Mehmet</au><au>Gunes, Fahri</au><au>Binnetoglu, Emine</au><au>Eroglu, Mustafa</au><au>Bozkurt, Neslihan</au><au>Sen, Hacer</au><au>Akbal, Erdem</au><au>Bakar, Coskun</au><au>Beyazit, Yavuz</au><au>Ukinc, Kubilay</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decrease in TSH levels after lactose restriction in Hashimoto’s thyroiditis patients with lactose intolerance</atitle><jtitle>Endocrine</jtitle><stitle>Endocrine</stitle><addtitle>Endocrine</addtitle><date>2014-06-01</date><risdate>2014</risdate><volume>46</volume><issue>2</issue><spage>279</spage><epage>284</epage><pages>279-284</pages><issn>1355-008X</issn><eissn>1559-0100</eissn><abstract>We aimed to evaluate the prevalence of lactose intolerance (LI) in patients with Hashimoto’s thyroiditis (HT) and the effects of lactose restriction on thyroid function in these patients. Eighty-three HT patients taking
l
-thyroxine (LT4) were enrolled, and lactose tolerance tests were performed on all patients. Lactose intolerance was diagnosed in 75.9 % of the patients with HT. Thirty-eight patients with LI were started on a lactose-restricted diet for 8 weeks. Thirty-eight patients with LI (30 euthyroid and 8 with subclinical hypothyroidism), and 12 patients without LI were included in the final analysis. The level of TSH significantly decreased in the euthyroid and subclinical hypothyroid patients with LI [from 2.06 ± 1.02 to 1.51 ± 1.1 IU/mL and from 5.45 ± 0.74 to 2.25 ± 1.88 IU/mL, respectively (both
P
< 0.05)]. However, the level of TSH in patients without LI did not change significantly over the 8 weeks (
P
> 0.05). Lactose intolerance occurs at a high frequency in HT patients. Lactose restriction leads to decreased levels of TSH, and LI should be considered in hypothyroid patients who require increasing LT4 doses, have irregular TSH levels and are resistant to LT4 treatment.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>24078411</pmid><doi>10.1007/s12020-013-0065-1</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Diabetes Diet Endocrinology Female Hashimoto Disease - blood Hashimoto Disease - complications Humanities and Social Sciences Humans Internal Medicine Lactose Intolerance - blood Lactose Intolerance - complications Lactose Intolerance - diet therapy Lactose Tolerance Test Male Medicine Medicine & Public Health Middle Aged multidisciplinary Original Article Science Thyrotropin - blood Treatment Outcome |
| title | Decrease in TSH levels after lactose restriction in Hashimoto’s thyroiditis patients with lactose intolerance |
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