Human Melatonin Suppression by Light is Intensity Dependent
Five intensities of artificial light were examined for the effect on nocturnal melatonin concentrations. Maximum suppression of melatonin following 1 hr of light at midnight was 71%, 67%, 44%, 38%, and 16% with intensities of 3,000, 1,000, 500, 350, and 200 lux (lx), respectively. In contrast to som...
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| Veröffentlicht in: | Journal of pineal research 1989-01, Vol.6 (2), p.149-156 |
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| container_title | Journal of pineal research |
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| creator | Mclntyre, Iain M. Norman, Trevor R. Burrows, Graham D. Armstrong, Stuart M. |
| description | Five intensities of artificial light were examined for the effect on nocturnal melatonin concentrations. Maximum suppression of melatonin following 1 hr of light at midnight was 71%, 67%, 44%, 38%, and 16% with intensities of 3,000, 1,000, 500, 350, and 200 lux (lx), respectively. In contrast to some previous reports, light of 1,000 lx intensity was sufficient to suppress melatonin to near daytime levels, and intensities down to 350 lx were shown to significantly suppress nocturnal melatonin levels below prelight values. On the basis of these data, it is suggested that when examining the melatonin sensitivity of patient groups (such as bipolar affective disorders) to artificial light, an appropriate light intensity should be established in each laboratory. Light of less intensity (e.g., 200–350 lx) may be more suitable to dichotomize patient groups from control subjects. |
| doi_str_mv | 10.1111/j.1600-079X.1989.tb00412.x |
| format | Article |
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Maximum suppression of melatonin following 1 hr of light at midnight was 71%, 67%, 44%, 38%, and 16% with intensities of 3,000, 1,000, 500, 350, and 200 lux (lx), respectively. In contrast to some previous reports, light of 1,000 lx intensity was sufficient to suppress melatonin to near daytime levels, and intensities down to 350 lx were shown to significantly suppress nocturnal melatonin levels below prelight values. On the basis of these data, it is suggested that when examining the melatonin sensitivity of patient groups (such as bipolar affective disorders) to artificial light, an appropriate light intensity should be established in each laboratory. 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Maximum suppression of melatonin following 1 hr of light at midnight was 71%, 67%, 44%, 38%, and 16% with intensities of 3,000, 1,000, 500, 350, and 200 lux (lx), respectively. In contrast to some previous reports, light of 1,000 lx intensity was sufficient to suppress melatonin to near daytime levels, and intensities down to 350 lx were shown to significantly suppress nocturnal melatonin levels below prelight values. On the basis of these data, it is suggested that when examining the melatonin sensitivity of patient groups (such as bipolar affective disorders) to artificial light, an appropriate light intensity should be established in each laboratory. Light of less intensity (e.g., 200–350 lx) may be more suitable to dichotomize patient groups from control subjects.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Bipolar Disorder - physiopathology</subject><subject>Dose-Response Relationship, Radiation</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hormones and neuropeptides. Regulation</subject><subject>Humans</subject><subject>Hypothalamus. Hypophysis. Epiphysis. Urophysis</subject><subject>Light</subject><subject>Lighting</subject><subject>low light intensity</subject><subject>Male</subject><subject>melatonin</subject><subject>Melatonin - blood</subject><subject>Reference Values</subject><subject>Vertebrates: endocrinology</subject><issn>0742-3098</issn><issn>1600-079X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkF1r2zAUhsXoaLNsP6FgCu2dPR3JtqwWBqWfGVlWmo32TsjKcavMkT3Lpsm_n0NMer1zcy7ej3N4CDkBGkE_X5cRpJSGVMjnCGQmozanNAYWrT-Q0V46ICMqYhZyKrMj8sn7JaU0y7L0kBwyCQln8Yhc3Hcr7YIfWOq2ctYF866uG_TeVi7IN8HUvry2gfXBxLXovG03wTXW6Bbo2s_kY6FLj1-GPSa_b29-Xd2H0593k6vLaWgSCTJkoJlmwgiGGot4oWMhjdQp5DmYAiFLEXNuOE9EYjLKhJA58KIAKlEbkfIxOdv11k31t0PfqpX1BstSO6w6ryCJecw49MbzndE0lfcNFqpu7Eo3GwVUbcmppdriUVs8aktODeTUug8fD1e6fIWLfXRA1eung6690WXRaGesf78gmWQiob3v2873Zkvc_McH6vvDBGLZF4S7AutbXO8LdPNHpYKLRD3N7tT1I9zyZDZXc_4Ppq6aNw</recordid><startdate>19890101</startdate><enddate>19890101</enddate><creator>Mclntyre, Iain M.</creator><creator>Norman, Trevor R.</creator><creator>Burrows, Graham D.</creator><creator>Armstrong, Stuart M.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>19890101</creationdate><title>Human Melatonin Suppression by Light is Intensity Dependent</title><author>Mclntyre, Iain M. ; Norman, Trevor R. ; Burrows, Graham D. ; Armstrong, Stuart M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5919-21a2a27c72eaef4da479c9a61bb1cfe186eeb3c33575c802779b13ff109eac763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Bipolar Disorder - physiopathology</topic><topic>Dose-Response Relationship, Radiation</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hormones and neuropeptides. Regulation</topic><topic>Humans</topic><topic>Hypothalamus. Hypophysis. Epiphysis. Urophysis</topic><topic>Light</topic><topic>Lighting</topic><topic>low light intensity</topic><topic>Male</topic><topic>melatonin</topic><topic>Melatonin - blood</topic><topic>Reference Values</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mclntyre, Iain M.</creatorcontrib><creatorcontrib>Norman, Trevor R.</creatorcontrib><creatorcontrib>Burrows, Graham D.</creatorcontrib><creatorcontrib>Armstrong, Stuart M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Journal of pineal research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mclntyre, Iain M.</au><au>Norman, Trevor R.</au><au>Burrows, Graham D.</au><au>Armstrong, Stuart M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human Melatonin Suppression by Light is Intensity Dependent</atitle><jtitle>Journal of pineal research</jtitle><addtitle>J Pineal Res</addtitle><date>1989-01-01</date><risdate>1989</risdate><volume>6</volume><issue>2</issue><spage>149</spage><epage>156</epage><pages>149-156</pages><issn>0742-3098</issn><eissn>1600-079X</eissn><coden>JPRSE9</coden><abstract>Five intensities of artificial light were examined for the effect on nocturnal melatonin concentrations. Maximum suppression of melatonin following 1 hr of light at midnight was 71%, 67%, 44%, 38%, and 16% with intensities of 3,000, 1,000, 500, 350, and 200 lux (lx), respectively. In contrast to some previous reports, light of 1,000 lx intensity was sufficient to suppress melatonin to near daytime levels, and intensities down to 350 lx were shown to significantly suppress nocturnal melatonin levels below prelight values. On the basis of these data, it is suggested that when examining the melatonin sensitivity of patient groups (such as bipolar affective disorders) to artificial light, an appropriate light intensity should be established in each laboratory. Light of less intensity (e.g., 200–350 lx) may be more suitable to dichotomize patient groups from control subjects.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>2915324</pmid><doi>10.1111/j.1600-079X.1989.tb00412.x</doi><tpages>8</tpages></addata></record> |
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| ispartof | Journal of pineal research, 1989-01, Vol.6 (2), p.149-156 |
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| subjects | Adult Biological and medical sciences Bipolar Disorder - physiopathology Dose-Response Relationship, Radiation Female Fundamental and applied biological sciences. Psychology Hormones and neuropeptides. Regulation Humans Hypothalamus. Hypophysis. Epiphysis. Urophysis Light Lighting low light intensity Male melatonin Melatonin - blood Reference Values Vertebrates: endocrinology |
| title | Human Melatonin Suppression by Light is Intensity Dependent |
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