Antibiotic-Associated Pseudomembranous Colitis: An Epidemiologic Investigation of a Cluster of Cases
Ten cases of antibiotic-associated colitis (AAC) were identified at a hospital in Washington, D.C., from March 17 to May 9, 1979. No geographic clustering of cases was found, nor was an association with increased use of antibiotics demonstrated. Exposure to aminoglycosides, cephalosporins, and clind...
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| Veröffentlicht in: | The Journal of infectious diseases 1982-02, Vol.145 (2), p.269-274 |
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| container_title | The Journal of infectious diseases |
| container_volume | 145 |
| creator | Pierce, P. F. Wilson, R. Silva, J. Garagusi, V. F. Rifkin, G. D. Fekety, R. Nunez-Montiel, O. Dowell, V. R. Hughes, J. M. |
| description | Ten cases of antibiotic-associated colitis (AAC) were identified at a hospital in Washington, D.C., from March 17 to May 9, 1979. No geographic clustering of cases was found, nor was an association with increased use of antibiotics demonstrated. Exposure to aminoglycosides, cephalosporins, and clindamycin was associated with AAC, as was a history of enemas in the seven days before the onset of illness (P = 0.045). This association was strengthened when gastrointestinal procedures-defined as (1) three or more enemas per week, (2) the insertion of a nasogastric tube for two or more days, or (3) gastrointestinal surgery - were performed within seven days of the onset of illness (P = 0.007). Clostridium difficile was not isolated from the hospital environments, nursing personnel, or family members of the patients. C. difficile was isolated from stool specimens of five (36%) of 14 patients who served as controls. |
| doi_str_mv | 10.1093/infdis/145.2.269 |
| format | Article |
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F. ; Wilson, R. ; Silva, J. ; Garagusi, V. F. ; Rifkin, G. D. ; Fekety, R. ; Nunez-Montiel, O. ; Dowell, V. R. ; Hughes, J. M.</creator><creatorcontrib>Pierce, P. F. ; Wilson, R. ; Silva, J. ; Garagusi, V. F. ; Rifkin, G. D. ; Fekety, R. ; Nunez-Montiel, O. ; Dowell, V. R. ; Hughes, J. M.</creatorcontrib><description>Ten cases of antibiotic-associated colitis (AAC) were identified at a hospital in Washington, D.C., from March 17 to May 9, 1979. No geographic clustering of cases was found, nor was an association with increased use of antibiotics demonstrated. Exposure to aminoglycosides, cephalosporins, and clindamycin was associated with AAC, as was a history of enemas in the seven days before the onset of illness (P = 0.045). This association was strengthened when gastrointestinal procedures-defined as (1) three or more enemas per week, (2) the insertion of a nasogastric tube for two or more days, or (3) gastrointestinal surgery - were performed within seven days of the onset of illness (P = 0.007). Clostridium difficile was not isolated from the hospital environments, nursing personnel, or family members of the patients. C. difficile was isolated from stool specimens of five (36%) of 14 patients who served as controls.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/145.2.269</identifier><identifier>PMID: 7054330</identifier><language>eng</language><publisher>United States: The University of Chicago Press</publisher><subject>Adult ; Aged ; Aminoglycosides - adverse effects ; Anti-Bacterial Agents - adverse effects ; Antibiotics ; Cephalosporins - adverse effects ; Clindamycin - adverse effects ; Clostridium - isolation & purification ; Clostridium difficile ; Colitis ; Colitis - chemically induced ; Diarrhea ; Diseases ; Enema ; Enema - adverse effects ; Epidemiology ; Female ; Hospital units ; Humans ; Intubation, Gastrointestinal - adverse effects ; Male ; Middle Aged ; Nurses ; Surgical Procedures, Operative - adverse effects ; Surgical specialties ; Toxins</subject><ispartof>The Journal of infectious diseases, 1982-02, Vol.145 (2), p.269-274</ispartof><rights>Copyright 1982 The University of Chicago</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c366t-bb5b5c28b90d7c9ff414b497370d9556e154ee787cd91901ef7855fbf040faa3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30082288$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30082288$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7054330$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pierce, P. F.</creatorcontrib><creatorcontrib>Wilson, R.</creatorcontrib><creatorcontrib>Silva, J.</creatorcontrib><creatorcontrib>Garagusi, V. F.</creatorcontrib><creatorcontrib>Rifkin, G. D.</creatorcontrib><creatorcontrib>Fekety, R.</creatorcontrib><creatorcontrib>Nunez-Montiel, O.</creatorcontrib><creatorcontrib>Dowell, V. R.</creatorcontrib><creatorcontrib>Hughes, J. M.</creatorcontrib><title>Antibiotic-Associated Pseudomembranous Colitis: An Epidemiologic Investigation of a Cluster of Cases</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Ten cases of antibiotic-associated colitis (AAC) were identified at a hospital in Washington, D.C., from March 17 to May 9, 1979. No geographic clustering of cases was found, nor was an association with increased use of antibiotics demonstrated. Exposure to aminoglycosides, cephalosporins, and clindamycin was associated with AAC, as was a history of enemas in the seven days before the onset of illness (P = 0.045). This association was strengthened when gastrointestinal procedures-defined as (1) three or more enemas per week, (2) the insertion of a nasogastric tube for two or more days, or (3) gastrointestinal surgery - were performed within seven days of the onset of illness (P = 0.007). Clostridium difficile was not isolated from the hospital environments, nursing personnel, or family members of the patients. C. difficile was isolated from stool specimens of five (36%) of 14 patients who served as controls.</description><subject>Adult</subject><subject>Aged</subject><subject>Aminoglycosides - adverse effects</subject><subject>Anti-Bacterial Agents - adverse effects</subject><subject>Antibiotics</subject><subject>Cephalosporins - adverse effects</subject><subject>Clindamycin - adverse effects</subject><subject>Clostridium - isolation & purification</subject><subject>Clostridium difficile</subject><subject>Colitis</subject><subject>Colitis - chemically induced</subject><subject>Diarrhea</subject><subject>Diseases</subject><subject>Enema</subject><subject>Enema - adverse effects</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Hospital units</subject><subject>Humans</subject><subject>Intubation, Gastrointestinal - adverse effects</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nurses</subject><subject>Surgical Procedures, Operative - adverse effects</subject><subject>Surgical specialties</subject><subject>Toxins</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1r3DAQhkVoSbdJ7r0UfOrNm5H1Yau3xaT5YGlLySHkIiRZCkptayvJof33VdhlcxqGZ95h5kHoE4Y1BkEu_ewGny4xZetm3XBxglaYkbbmHJN3aAXQNDXuhPiAPqb0DACU8PYUnbbAKCGwQsNmzl77kL2pNykF41W2Q_Uz2WUIk510VHNYUtWH0Wefvlabubra-cFOPozhyZvqdn6xKfsnlX2Yq-AqVfXjkrKNr02vkk3n6L1TY7IXh3qG7r9d3fc39fbH9W2_2daGcJ5rrZlmpum0gKE1wjmKqaaiJS0MgjFuMaPWtl1rBoEFYOvajjGnHVBwSpEz9GW_dhfDn6UcJSefjB1HNdvygyxxQgGTMgj7QRNDStE6uYt-UvGfxCBfvcq9V1m8ykYWryXy-bB70ZMdjoGDyDf-nHKIR0wAuqbpusLrPffFzN8jV_G35OVBJm8eHuXj9vuva97fSUr-A6yNjxQ</recordid><startdate>198202</startdate><enddate>198202</enddate><creator>Pierce, P. F.</creator><creator>Wilson, R.</creator><creator>Silva, J.</creator><creator>Garagusi, V. F.</creator><creator>Rifkin, G. D.</creator><creator>Fekety, R.</creator><creator>Nunez-Montiel, O.</creator><creator>Dowell, V. R.</creator><creator>Hughes, J. M.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope></search><sort><creationdate>198202</creationdate><title>Antibiotic-Associated Pseudomembranous Colitis: An Epidemiologic Investigation of a Cluster of Cases</title><author>Pierce, P. F. ; Wilson, R. ; Silva, J. ; Garagusi, V. F. ; Rifkin, G. D. ; Fekety, R. ; Nunez-Montiel, O. ; Dowell, V. R. ; Hughes, J. 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F.</creatorcontrib><creatorcontrib>Wilson, R.</creatorcontrib><creatorcontrib>Silva, J.</creatorcontrib><creatorcontrib>Garagusi, V. F.</creatorcontrib><creatorcontrib>Rifkin, G. D.</creatorcontrib><creatorcontrib>Fekety, R.</creatorcontrib><creatorcontrib>Nunez-Montiel, O.</creatorcontrib><creatorcontrib>Dowell, V. R.</creatorcontrib><creatorcontrib>Hughes, J. M.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pierce, P. F.</au><au>Wilson, R.</au><au>Silva, J.</au><au>Garagusi, V. F.</au><au>Rifkin, G. D.</au><au>Fekety, R.</au><au>Nunez-Montiel, O.</au><au>Dowell, V. R.</au><au>Hughes, J. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antibiotic-Associated Pseudomembranous Colitis: An Epidemiologic Investigation of a Cluster of Cases</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1982-02</date><risdate>1982</risdate><volume>145</volume><issue>2</issue><spage>269</spage><epage>274</epage><pages>269-274</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><abstract>Ten cases of antibiotic-associated colitis (AAC) were identified at a hospital in Washington, D.C., from March 17 to May 9, 1979. No geographic clustering of cases was found, nor was an association with increased use of antibiotics demonstrated. Exposure to aminoglycosides, cephalosporins, and clindamycin was associated with AAC, as was a history of enemas in the seven days before the onset of illness (P = 0.045). This association was strengthened when gastrointestinal procedures-defined as (1) three or more enemas per week, (2) the insertion of a nasogastric tube for two or more days, or (3) gastrointestinal surgery - were performed within seven days of the onset of illness (P = 0.007). Clostridium difficile was not isolated from the hospital environments, nursing personnel, or family members of the patients. C. difficile was isolated from stool specimens of five (36%) of 14 patients who served as controls.</abstract><cop>United States</cop><pub>The University of Chicago Press</pub><pmid>7054330</pmid><doi>10.1093/infdis/145.2.269</doi><tpages>6</tpages></addata></record> |
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| ispartof | The Journal of infectious diseases, 1982-02, Vol.145 (2), p.269-274 |
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| subjects | Adult Aged Aminoglycosides - adverse effects Anti-Bacterial Agents - adverse effects Antibiotics Cephalosporins - adverse effects Clindamycin - adverse effects Clostridium - isolation & purification Clostridium difficile Colitis Colitis - chemically induced Diarrhea Diseases Enema Enema - adverse effects Epidemiology Female Hospital units Humans Intubation, Gastrointestinal - adverse effects Male Middle Aged Nurses Surgical Procedures, Operative - adverse effects Surgical specialties Toxins |
| title | Antibiotic-Associated Pseudomembranous Colitis: An Epidemiologic Investigation of a Cluster of Cases |
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