Effect of Glycyl-L-glutamine on the Rate of Regeneration of Acetylcholinesterase in the Rat Gastrocnemius Muscle after Diisopropyl Phosphorofluoridate Administration
Rats were given glycyl-L-glutamine (Gly-Gln) by intraaortic infusion with Alzet osmotic pumps during the 48-hr period following the intraaortic administration of diisopropyl phosphorofluoridate (DFP) (10 μ mol/kg). The infusion of 1.2 μ mol of Gly-Gln per 24 hr resulted in a significant increase in...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1989-06, Vol.86 (11), p.4331-4333 |
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| creator | Koelle, George B. Han, Matthew S. |
| description | Rats were given glycyl-L-glutamine (Gly-Gln) by intraaortic infusion with Alzet osmotic pumps during the 48-hr period following the intraaortic administration of diisopropyl phosphorofluoridate (DFP) (10 μ mol/kg). The infusion of 1.2 μ mol of Gly-Gln per 24 hr resulted in a significant increase in the acetylcholinesterase (AcChoEase; acetylcholine acetylhydrolase, EC 3.1.1.7) activity of the gastrocnemius muscles over that of rats that received DFP only. At a total dose of 3.6 μ mol per 24 hr, a diminished result was obtained; at 0.36 μ mol per 24 hr, no effect was detectable. These findings, together with earlier ones, suggest that the neurotrophic effect of Gly-Gln or a similar endogenous factor on AcChoEase synthesis is a general phenomenon at sites of cholinergic transmission. |
| doi_str_mv | 10.1073/pnas.86.11.4331 |
| format | Article |
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The infusion of 1.2 μ mol of Gly-Gln per 24 hr resulted in a significant increase in the acetylcholinesterase (AcChoEase; acetylcholine acetylhydrolase, EC 3.1.1.7) activity of the gastrocnemius muscles over that of rats that received DFP only. At a total dose of 3.6 μ mol per 24 hr, a diminished result was obtained; at 0.36 μ mol per 24 hr, no effect was detectable. These findings, together with earlier ones, suggest that the neurotrophic effect of Gly-Gln or a similar endogenous factor on AcChoEase synthesis is a general phenomenon at sites of cholinergic transmission.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.86.11.4331</identifier><identifier>PMID: 2726774</identifier><identifier>CODEN: PNASA6</identifier><language>eng</language><publisher>Washington, DC: National Academy of Sciences of the United States of America</publisher><subject>Abdominal aorta ; Acetylcholinesterase - metabolism ; Animals ; Biological and medical sciences ; Catheters ; Cholinergics ; Dipeptides - pharmacology ; Dosage ; Educational administration ; Fundamental and applied biological sciences. Psychology ; Intragastric administration ; Intramuscular injections ; Isoflurophate - pharmacology ; Kinetics ; Muscles ; Muscles - drug effects ; Muscles - enzymology ; Neural Inhibition ; Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. 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The infusion of 1.2 μ mol of Gly-Gln per 24 hr resulted in a significant increase in the acetylcholinesterase (AcChoEase; acetylcholine acetylhydrolase, EC 3.1.1.7) activity of the gastrocnemius muscles over that of rats that received DFP only. At a total dose of 3.6 μ mol per 24 hr, a diminished result was obtained; at 0.36 μ mol per 24 hr, no effect was detectable. These findings, together with earlier ones, suggest that the neurotrophic effect of Gly-Gln or a similar endogenous factor on AcChoEase synthesis is a general phenomenon at sites of cholinergic transmission.</description><subject>Abdominal aorta</subject><subject>Acetylcholinesterase - metabolism</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Catheters</subject><subject>Cholinergics</subject><subject>Dipeptides - pharmacology</subject><subject>Dosage</subject><subject>Educational administration</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Intragastric administration</subject><subject>Intramuscular injections</subject><subject>Isoflurophate - pharmacology</subject><subject>Kinetics</subject><subject>Muscles</subject><subject>Muscles - drug effects</subject><subject>Muscles - enzymology</subject><subject>Neural Inhibition</subject><subject>Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ</subject><subject>Pumps</subject><subject>Rats</subject><subject>Reference Values</subject><subject>Time Factors</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk2LEzEcxgdR1rp6FgQlF_U03bxMXubgoaxrFSrKoueQpkmbJZ3MJhlxPpDf04ytXb3oKYTn9_zfq-opgnMEObnoO5Xmgs0RmjeEoHvVDMEW1axp4f1qBiHmtWhw87B6lNINhLClAp5VZ5hjxnkzq35cWWt0BsGCpR_16OtVvfVDVnvXGRA6kHcGXKtsJuLabE1nosquCOW_0CaPXu-CL3DKRUkGuJMHLFXKMejO7N2QwMchaW-AsgUEb51LoY-hHz34vAup34UYrB9CdJsp22JTCnDF_ivZ4-qBVT6ZJ8f3vPr67urL5ft69Wn54XKxqjXFONcbjTAxazv1SRTlCGKi11wwY7TmQjctJ0JTpFsGOTQYMyoI5WVY1GJELDmv3hzi9sN6bzbadKUAL_vo9iqOMign_1Y6t5Pb8E1iwZuGFf-roz-G26GMRO5d0sZ71ZkwJMlbiFrK4X9BRMs2KUMFvDiAOoaUorGnYhCU0wXI6QKkYBIhOV1AcTz_s4cTf1x50V8edZW08jaqTrt0F7ZlCDJBC_f6yE0Jfst3iaQdvM_mey7ki3-SBXh2AG5SDvFEEMIEIj8BZs3evA</recordid><startdate>19890601</startdate><enddate>19890601</enddate><creator>Koelle, George B.</creator><creator>Han, Matthew S.</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19890601</creationdate><title>Effect of Glycyl-L-glutamine on the Rate of Regeneration of Acetylcholinesterase in the Rat Gastrocnemius Muscle after Diisopropyl Phosphorofluoridate Administration</title><author>Koelle, George B. ; Han, Matthew S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c522t-dc123ebf00093a571023cb786eecc78c49738c51c96070e226583576495f213f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Abdominal aorta</topic><topic>Acetylcholinesterase - metabolism</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Catheters</topic><topic>Cholinergics</topic><topic>Dipeptides - pharmacology</topic><topic>Dosage</topic><topic>Educational administration</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Intragastric administration</topic><topic>Intramuscular injections</topic><topic>Isoflurophate - pharmacology</topic><topic>Kinetics</topic><topic>Muscles</topic><topic>Muscles - drug effects</topic><topic>Muscles - enzymology</topic><topic>Neural Inhibition</topic><topic>Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ</topic><topic>Pumps</topic><topic>Rats</topic><topic>Reference Values</topic><topic>Time Factors</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koelle, George B.</creatorcontrib><creatorcontrib>Han, Matthew S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koelle, George B.</au><au>Han, Matthew S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Glycyl-L-glutamine on the Rate of Regeneration of Acetylcholinesterase in the Rat Gastrocnemius Muscle after Diisopropyl Phosphorofluoridate Administration</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1989-06-01</date><risdate>1989</risdate><volume>86</volume><issue>11</issue><spage>4331</spage><epage>4333</epage><pages>4331-4333</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><coden>PNASA6</coden><abstract>Rats were given glycyl-L-glutamine (Gly-Gln) by intraaortic infusion with Alzet osmotic pumps during the 48-hr period following the intraaortic administration of diisopropyl phosphorofluoridate (DFP) (10 μ mol/kg). The infusion of 1.2 μ mol of Gly-Gln per 24 hr resulted in a significant increase in the acetylcholinesterase (AcChoEase; acetylcholine acetylhydrolase, EC 3.1.1.7) activity of the gastrocnemius muscles over that of rats that received DFP only. At a total dose of 3.6 μ mol per 24 hr, a diminished result was obtained; at 0.36 μ mol per 24 hr, no effect was detectable. These findings, together with earlier ones, suggest that the neurotrophic effect of Gly-Gln or a similar endogenous factor on AcChoEase synthesis is a general phenomenon at sites of cholinergic transmission.</abstract><cop>Washington, DC</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>2726774</pmid><doi>10.1073/pnas.86.11.4331</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Abdominal aorta Acetylcholinesterase - metabolism Animals Biological and medical sciences Catheters Cholinergics Dipeptides - pharmacology Dosage Educational administration Fundamental and applied biological sciences. Psychology Intragastric administration Intramuscular injections Isoflurophate - pharmacology Kinetics Muscles Muscles - drug effects Muscles - enzymology Neural Inhibition Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ Pumps Rats Reference Values Time Factors Vertebrates: nervous system and sense organs |
| title | Effect of Glycyl-L-glutamine on the Rate of Regeneration of Acetylcholinesterase in the Rat Gastrocnemius Muscle after Diisopropyl Phosphorofluoridate Administration |
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