Development of an analytical procedure for quantifying the underivatized neurotoxin β-N-methylamino-l-alanine in brain tissues

The cyanotoxin β-methylamino- l -alanine (BMAA) has received renewed attention as an environmental risk factor for sporadic cases of amyotrophic lateral sclerosis (ALS) (Nunn et al., Brain Res 410:375–379, 1987 ). The aim of the present study was to develop and to validate an analytical procedure th...

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Veröffentlicht in:	Analytical and Bioanalytical Biochemistry 2014-07, Vol.406 (19), p.4627-4636
Hauptverfasser:	Combes, Audrey, El Abdellaoui, Saïda, Vial, Jérome, Lagrange, Emmeline, Pichon, Valérie
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Amino Acids, Diamino - analysis Aminobutyrates - analysis Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - chemically induced Analysis Analytical Chemistry Animals Biochemistry Biodiversity and Ecology Brain Cattle Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Chromatography, Reverse-Phase - methods Cyclohexane Environmental risk Environmental Sciences Extraction procedures Food Science Hippocampus - chemistry Humans L-Alanine Laboratory Medicine Lipids Liquid-liquid extraction Mathematical analysis Measurement Monitoring/Environmental Analysis Neurotoxins Reproducibility of Results Research Paper Risk analysis Risk factors Solid Phase Extraction - methods Solid phases Sorbents Tandem Mass Spectrometry - methods Toxins Washing
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