A centrifugal fluidic immunoassay for ocular diagnostics with an enzymatically hydrolyzed fluorogenic substrate

We present a novel "Lab-on-a-Disk" platform and demonstrate its capability for rapid and sensitive measurement of vascular endothelial growth factor (VEGF) intended for patients suffering from diabetic retinopathy (DR) and age-related macular degeneration (AMD). This approach combines sedi...

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Veröffentlicht in:	Lab on a chip 2014-08, Vol.14 (15), p.2673-2680
Hauptverfasser:	Walsh, 3rd, David I, Sommer, Gregory J, Schaff, Ulrich Y, Hahn, Paul S, Jaffe, Glenn J, Murthy, Shashi K
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aqueous Humor - metabolism Biomarkers - metabolism Centrifugation Diabetic Retinopathy - physiopathology Equipment Design Fluorescent Dyes - metabolism Humans Immunoassay - instrumentation Limit of Detection Macular Degeneration - physiopathology Macular Edema - diagnosis Macular Edema - etiology Macular Edema - metabolism Materials Testing Microchemistry - instrumentation Microfluidic Analytical Techniques - instrumentation Microspheres Point-of-Care Systems Sensitivity and Specificity Time Factors Vascular Endothelial Growth Factor A - metabolism Wet Macular Degeneration - diagnosis Wet Macular Degeneration - etiology Wet Macular Degeneration - metabolism
Online-Zugang:	Volltext
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