Insulin-like growth factor I, insulin-like growth factor binding protein 3, and atrial fibrillation in the elderly
Insulin-like growth factor I (IGF-I) and insulin-like growth factor binding protein 3 (IGFBP-3) are involved in oxidative stress and atherosclerosis; however, the relationship between the IGF-I system and atrial fibrillation (AF) is not known. The objective of this analysis was to assess, the relati...
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| Veröffentlicht in: | The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2014-08, Vol.69 (8), p.1025-1032 |
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| container_title | The journals of gerontology. Series A, Biological sciences and medical sciences |
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| creator | Duron, Emmanuelle Vidal, Jean-Sébastien Funalot, Benoît Brunel, Nadège Viollet, Cécile Seux, Marie-Laure Treluyer, Jean-Marc Epelbaum, Jacques Bouc, Yves Le Hanon, Olivier |
| description | Insulin-like growth factor I (IGF-I) and insulin-like growth factor binding protein 3 (IGFBP-3) are involved in oxidative stress and atherosclerosis; however, the relationship between the IGF-I system and atrial fibrillation (AF) is not known. The objective of this analysis was to assess, the relationship between IGF-I and IGFBP-3 serum levels and AF among elderly participants.
In this cross-sectional study, 719 participants (mean age [SD] years: 78.2 [6.8]; 31.8% men) were evaluated during an outpatient geriatric assessment. AF was determined by electrocardiogram or medical record. Participants were classified into two groups: Participants with AF (n = 91) or without AF (n = 628). IGF-I and IGFBP-3 serum levels were determined by enzyme linked immunosorbent assay.
After adjusting for age and sex, the mean IGF-I and IGFBP-3 serum levels were significantly lower among AF participants than among non-AF participants (mean IGF-I ng/mL [SD] = 133.8 [66.6] vs 157.9 [80.0], p = .02; mean IGFBP-3 ng/mL [SD] = 3,653 [1,393] vs 4,151 [1,583], p = .03, respectively). After adjusting for confounding factors (age, gender, beta blocker medication, heart rate, hypertension, stroke, and chronic heart failure), low IGF-I serum level (OR [95% CI] = 0.66 [0.49-0.87]) and low IGFBP-3 serum level (0.71 [0.54-0.93]) remained independent determinants of AF.
Low IGF-I and low IGFBP-3 serum levels were independently associated with AF in this elderly population. This result should be confirmed in a longitudinal study to evaluate whether IGF-I and/or IGFBP-3 serum levels are predictive of incident AF. |
| doi_str_mv | 10.1093/gerona/glt206 |
| format | Article |
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In this cross-sectional study, 719 participants (mean age [SD] years: 78.2 [6.8]; 31.8% men) were evaluated during an outpatient geriatric assessment. AF was determined by electrocardiogram or medical record. Participants were classified into two groups: Participants with AF (n = 91) or without AF (n = 628). IGF-I and IGFBP-3 serum levels were determined by enzyme linked immunosorbent assay.
After adjusting for age and sex, the mean IGF-I and IGFBP-3 serum levels were significantly lower among AF participants than among non-AF participants (mean IGF-I ng/mL [SD] = 133.8 [66.6] vs 157.9 [80.0], p = .02; mean IGFBP-3 ng/mL [SD] = 3,653 [1,393] vs 4,151 [1,583], p = .03, respectively). After adjusting for confounding factors (age, gender, beta blocker medication, heart rate, hypertension, stroke, and chronic heart failure), low IGF-I serum level (OR [95% CI] = 0.66 [0.49-0.87]) and low IGFBP-3 serum level (0.71 [0.54-0.93]) remained independent determinants of AF.
Low IGF-I and low IGFBP-3 serum levels were independently associated with AF in this elderly population. This result should be confirmed in a longitudinal study to evaluate whether IGF-I and/or IGFBP-3 serum levels are predictive of incident AF.</description><identifier>ISSN: 1079-5006</identifier><identifier>EISSN: 1758-535X</identifier><identifier>DOI: 10.1093/gerona/glt206</identifier><identifier>PMID: 24368776</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Aged ; Aged, 80 and over ; Atrial Fibrillation - blood ; Binding sites ; Cardiac arrhythmia ; Cross-Sectional Studies ; Female ; Gerontology ; Humans ; Immunoassay ; Insulin-Like Growth Factor Binding Protein 3 - blood ; Insulin-Like Growth Factor I - analysis ; Insulin-like growth factors ; Logistic Models ; Male ; Older people ; Proteins</subject><ispartof>The journals of gerontology. Series A, Biological sciences and medical sciences, 2014-08, Vol.69 (8), p.1025-1032</ispartof><rights>The Author 2013. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><rights>Copyright Oxford University Press, UK Aug 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-8c872139719dd2876509868414323d81c6defc229336d2402ab5893062365fb63</citedby><cites>FETCH-LOGICAL-c360t-8c872139719dd2876509868414323d81c6defc229336d2402ab5893062365fb63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24368776$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Duron, Emmanuelle</creatorcontrib><creatorcontrib>Vidal, Jean-Sébastien</creatorcontrib><creatorcontrib>Funalot, Benoît</creatorcontrib><creatorcontrib>Brunel, Nadège</creatorcontrib><creatorcontrib>Viollet, Cécile</creatorcontrib><creatorcontrib>Seux, Marie-Laure</creatorcontrib><creatorcontrib>Treluyer, Jean-Marc</creatorcontrib><creatorcontrib>Epelbaum, Jacques</creatorcontrib><creatorcontrib>Bouc, Yves Le</creatorcontrib><creatorcontrib>Hanon, Olivier</creatorcontrib><title>Insulin-like growth factor I, insulin-like growth factor binding protein 3, and atrial fibrillation in the elderly</title><title>The journals of gerontology. Series A, Biological sciences and medical sciences</title><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><description>Insulin-like growth factor I (IGF-I) and insulin-like growth factor binding protein 3 (IGFBP-3) are involved in oxidative stress and atherosclerosis; however, the relationship between the IGF-I system and atrial fibrillation (AF) is not known. The objective of this analysis was to assess, the relationship between IGF-I and IGFBP-3 serum levels and AF among elderly participants.
In this cross-sectional study, 719 participants (mean age [SD] years: 78.2 [6.8]; 31.8% men) were evaluated during an outpatient geriatric assessment. AF was determined by electrocardiogram or medical record. Participants were classified into two groups: Participants with AF (n = 91) or without AF (n = 628). IGF-I and IGFBP-3 serum levels were determined by enzyme linked immunosorbent assay.
After adjusting for age and sex, the mean IGF-I and IGFBP-3 serum levels were significantly lower among AF participants than among non-AF participants (mean IGF-I ng/mL [SD] = 133.8 [66.6] vs 157.9 [80.0], p = .02; mean IGFBP-3 ng/mL [SD] = 3,653 [1,393] vs 4,151 [1,583], p = .03, respectively). After adjusting for confounding factors (age, gender, beta blocker medication, heart rate, hypertension, stroke, and chronic heart failure), low IGF-I serum level (OR [95% CI] = 0.66 [0.49-0.87]) and low IGFBP-3 serum level (0.71 [0.54-0.93]) remained independent determinants of AF.
Low IGF-I and low IGFBP-3 serum levels were independently associated with AF in this elderly population. This result should be confirmed in a longitudinal study to evaluate whether IGF-I and/or IGFBP-3 serum levels are predictive of incident AF.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Atrial Fibrillation - blood</subject><subject>Binding sites</subject><subject>Cardiac arrhythmia</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Gerontology</subject><subject>Humans</subject><subject>Immunoassay</subject><subject>Insulin-Like Growth Factor Binding Protein 3 - blood</subject><subject>Insulin-Like Growth Factor I - analysis</subject><subject>Insulin-like growth factors</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Older people</subject><subject>Proteins</subject><issn>1079-5006</issn><issn>1758-535X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUtLAzEURoMoPqpLtxJw48KxeUwes5Tio1Bwo-BuyEwyNZommmQQ_70prS4E7yYXcjh83A-AU4yuMGrodGli8Gq6dJkgvgMOsWCyYpQ975YdiaZiCPEDcJTSK1oPI_vggNSUSyH4IYhzn0ZnfeXsm4HLGD7zCxxUn0OE80to___trNfWL-F7DNlYD-klVF5DlaNVDg62i9Y5lW3wxQLzi4HGaRPd1zHYG5RL5mT7TsDT7c3j7L5aPNzNZ9eLqqcc5Ur2UhBMG4EbrYkUnKFGclnjmhKqJe65NkNPSEMp16RGRHVMNhRxQjkbOk4n4GLjLQk_RpNyu7KpNyWUN2FMLWbFJHEtmoKe_0Ffwxh9SbemGMVCUFmoakP1MaQUzdC-R7tS8avFqF2X0W7KaDdlFP5sax27ldG_9M_16Teod4X3</recordid><startdate>20140801</startdate><enddate>20140801</enddate><creator>Duron, Emmanuelle</creator><creator>Vidal, Jean-Sébastien</creator><creator>Funalot, Benoît</creator><creator>Brunel, Nadège</creator><creator>Viollet, Cécile</creator><creator>Seux, Marie-Laure</creator><creator>Treluyer, Jean-Marc</creator><creator>Epelbaum, Jacques</creator><creator>Bouc, Yves Le</creator><creator>Hanon, Olivier</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20140801</creationdate><title>Insulin-like growth factor I, insulin-like growth factor binding protein 3, and atrial fibrillation in the elderly</title><author>Duron, Emmanuelle ; Vidal, Jean-Sébastien ; Funalot, Benoît ; Brunel, Nadège ; Viollet, Cécile ; Seux, Marie-Laure ; Treluyer, Jean-Marc ; Epelbaum, Jacques ; Bouc, Yves Le ; Hanon, Olivier</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-8c872139719dd2876509868414323d81c6defc229336d2402ab5893062365fb63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Atrial Fibrillation - blood</topic><topic>Binding sites</topic><topic>Cardiac arrhythmia</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Gerontology</topic><topic>Humans</topic><topic>Immunoassay</topic><topic>Insulin-Like Growth Factor Binding Protein 3 - blood</topic><topic>Insulin-Like Growth Factor I - analysis</topic><topic>Insulin-like growth factors</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Older people</topic><topic>Proteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Duron, Emmanuelle</creatorcontrib><creatorcontrib>Vidal, Jean-Sébastien</creatorcontrib><creatorcontrib>Funalot, Benoît</creatorcontrib><creatorcontrib>Brunel, Nadège</creatorcontrib><creatorcontrib>Viollet, Cécile</creatorcontrib><creatorcontrib>Seux, Marie-Laure</creatorcontrib><creatorcontrib>Treluyer, Jean-Marc</creatorcontrib><creatorcontrib>Epelbaum, Jacques</creatorcontrib><creatorcontrib>Bouc, Yves Le</creatorcontrib><creatorcontrib>Hanon, Olivier</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>The journals of gerontology. Series A, Biological sciences and medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Duron, Emmanuelle</au><au>Vidal, Jean-Sébastien</au><au>Funalot, Benoît</au><au>Brunel, Nadège</au><au>Viollet, Cécile</au><au>Seux, Marie-Laure</au><au>Treluyer, Jean-Marc</au><au>Epelbaum, Jacques</au><au>Bouc, Yves Le</au><au>Hanon, Olivier</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Insulin-like growth factor I, insulin-like growth factor binding protein 3, and atrial fibrillation in the elderly</atitle><jtitle>The journals of gerontology. Series A, Biological sciences and medical sciences</jtitle><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><date>2014-08-01</date><risdate>2014</risdate><volume>69</volume><issue>8</issue><spage>1025</spage><epage>1032</epage><pages>1025-1032</pages><issn>1079-5006</issn><eissn>1758-535X</eissn><abstract>Insulin-like growth factor I (IGF-I) and insulin-like growth factor binding protein 3 (IGFBP-3) are involved in oxidative stress and atherosclerosis; however, the relationship between the IGF-I system and atrial fibrillation (AF) is not known. The objective of this analysis was to assess, the relationship between IGF-I and IGFBP-3 serum levels and AF among elderly participants.
In this cross-sectional study, 719 participants (mean age [SD] years: 78.2 [6.8]; 31.8% men) were evaluated during an outpatient geriatric assessment. AF was determined by electrocardiogram or medical record. Participants were classified into two groups: Participants with AF (n = 91) or without AF (n = 628). IGF-I and IGFBP-3 serum levels were determined by enzyme linked immunosorbent assay.
After adjusting for age and sex, the mean IGF-I and IGFBP-3 serum levels were significantly lower among AF participants than among non-AF participants (mean IGF-I ng/mL [SD] = 133.8 [66.6] vs 157.9 [80.0], p = .02; mean IGFBP-3 ng/mL [SD] = 3,653 [1,393] vs 4,151 [1,583], p = .03, respectively). After adjusting for confounding factors (age, gender, beta blocker medication, heart rate, hypertension, stroke, and chronic heart failure), low IGF-I serum level (OR [95% CI] = 0.66 [0.49-0.87]) and low IGFBP-3 serum level (0.71 [0.54-0.93]) remained independent determinants of AF.
Low IGF-I and low IGFBP-3 serum levels were independently associated with AF in this elderly population. This result should be confirmed in a longitudinal study to evaluate whether IGF-I and/or IGFBP-3 serum levels are predictive of incident AF.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>24368776</pmid><doi>10.1093/gerona/glt206</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The journals of gerontology. Series A, Biological sciences and medical sciences, 2014-08, Vol.69 (8), p.1025-1032 |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Aged Aged, 80 and over Atrial Fibrillation - blood Binding sites Cardiac arrhythmia Cross-Sectional Studies Female Gerontology Humans Immunoassay Insulin-Like Growth Factor Binding Protein 3 - blood Insulin-Like Growth Factor I - analysis Insulin-like growth factors Logistic Models Male Older people Proteins |
| title | Insulin-like growth factor I, insulin-like growth factor binding protein 3, and atrial fibrillation in the elderly |
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