Endothelial dysfunction is associated with a greater depressive symptom score in a general elderly population: the Hoorn Study
Endothelial dysfunction (ED), low-grade inflammation (LGI) and oxidative stress (OxS) may be involved in the pathobiology of depression. Previous studies on the association of these processes in depression have yielded contradictory results. We therefore investigated comprehensively, in a population...
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| Veröffentlicht in: | Psychological medicine 2014-05, Vol.44 (7), p.1403-1416 |
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| creator | van Sloten, T. T. Schram, M. T. Adriaanse, M. C. Dekker, J. M. Nijpels, G. Teerlink, T. Scheffer, P. G. Pouwer, F. Schalkwijk, C. G. Stehouwer, C. D. A. Henry, R. M. A. |
| description | Endothelial dysfunction (ED), low-grade inflammation (LGI) and oxidative stress (OxS) may be involved in the pathobiology of depression. Previous studies on the association of these processes in depression have yielded contradictory results. We therefore investigated comprehensively, in a population-based cohort study, the association between ED, LGI and OxS on the one hand and depressive symptoms on the other.
We used data from the Hoorn Study and determined biomarkers of ED [flow-mediated dilatation (FMD), von Willebrand factor, soluble intercellular adhesion molecule 1 (sICAM-1), soluble vascular cell adhesion molecule 1, soluble thrombomodulin and soluble endothelial selectin], LGI [C-reactive protein, tumour necrosis factor-α, interleukin 6, interleukin 8, serum amyloid A, myeloperoxidase (MPO) and sICAM-1] and OxS (oxidized low density lipoprotein and MPO). Depressive symptoms were quantified by the Center for Epidemiologic Studies Depression Scale (CES-D) questionnaire (n = 493; age 68 years; 49.9% female). Regression analyses were performed with the use of biomarker Z scores. Adjustments were made for age, sex and glucose metabolism status (cohort stratification variables) and prior cardiovascular disease, hypertension, waist-to-hip ratio, cholesterol levels, education level, physical activity, dietary habits, and the use of antihypertensive and/or lipid-lowering medication and/or metformin (potential confounders).
After adjustment for age, sex and glucose metabolism status, one standard deviation increase in the ED Z score was associated with a 1.9 [95% confidence interval (CI) 0.7-3.1] higher CES-D score. Additional adjustments did not materially change this result. LGI and OxS were not associated with the CES-D score.
ED, as quantified by an array of circulating biomarkers and FMD, was independently associated with depressive symptoms. This study supports the hypothesis that ED plays an important role in the pathobiology of depression. |
| doi_str_mv | 10.1017/S0033291713002043 |
| format | Article |
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We used data from the Hoorn Study and determined biomarkers of ED [flow-mediated dilatation (FMD), von Willebrand factor, soluble intercellular adhesion molecule 1 (sICAM-1), soluble vascular cell adhesion molecule 1, soluble thrombomodulin and soluble endothelial selectin], LGI [C-reactive protein, tumour necrosis factor-α, interleukin 6, interleukin 8, serum amyloid A, myeloperoxidase (MPO) and sICAM-1] and OxS (oxidized low density lipoprotein and MPO). Depressive symptoms were quantified by the Center for Epidemiologic Studies Depression Scale (CES-D) questionnaire (n = 493; age 68 years; 49.9% female). Regression analyses were performed with the use of biomarker Z scores. Adjustments were made for age, sex and glucose metabolism status (cohort stratification variables) and prior cardiovascular disease, hypertension, waist-to-hip ratio, cholesterol levels, education level, physical activity, dietary habits, and the use of antihypertensive and/or lipid-lowering medication and/or metformin (potential confounders).
After adjustment for age, sex and glucose metabolism status, one standard deviation increase in the ED Z score was associated with a 1.9 [95% confidence interval (CI) 0.7-3.1] higher CES-D score. Additional adjustments did not materially change this result. LGI and OxS were not associated with the CES-D score.
ED, as quantified by an array of circulating biomarkers and FMD, was independently associated with depressive symptoms. This study supports the hypothesis that ED plays an important role in the pathobiology of depression.</description><identifier>ISSN: 0033-2917</identifier><identifier>EISSN: 1469-8978</identifier><identifier>DOI: 10.1017/S0033291713002043</identifier><identifier>PMID: 23942242</identifier><identifier>CODEN: PSMDCO</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adjustment ; Adult and adolescent clinical studies ; Aged ; Biological and medical sciences ; Biological markers ; Biology ; Biomarkers ; Biomarkers - blood ; Blood vessels ; Depression ; Depression - epidemiology ; Depression - etiology ; Dysfunction ; Endothelium, Vascular - physiopathology ; Female ; Glucose ; Humans ; Inflammation - blood ; Inflammation - epidemiology ; Inflammatory diseases ; Male ; Medical sciences ; Mental depression ; Metabolism ; Middle Aged ; Miscellaneous ; Mood disorders ; Netherlands - epidemiology ; Older people ; Original Articles ; Oxidative stress ; Oxidative Stress - physiology ; Pathology ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry</subject><ispartof>Psychological medicine, 2014-05, Vol.44 (7), p.1403-1416</ispartof><rights>Copyright © Cambridge University Press 2013</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c512t-f66a5ee63bc17ff11d8088f5d11cba85d31872a31207d88c357b6ba5e24ccd5b3</citedby><cites>FETCH-LOGICAL-c512t-f66a5ee63bc17ff11d8088f5d11cba85d31872a31207d88c357b6ba5e24ccd5b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0033291713002043/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,776,780,12825,27901,27902,30976,30977,55603</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28398873$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23942242$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Sloten, T. T.</creatorcontrib><creatorcontrib>Schram, M. T.</creatorcontrib><creatorcontrib>Adriaanse, M. C.</creatorcontrib><creatorcontrib>Dekker, J. M.</creatorcontrib><creatorcontrib>Nijpels, G.</creatorcontrib><creatorcontrib>Teerlink, T.</creatorcontrib><creatorcontrib>Scheffer, P. G.</creatorcontrib><creatorcontrib>Pouwer, F.</creatorcontrib><creatorcontrib>Schalkwijk, C. G.</creatorcontrib><creatorcontrib>Stehouwer, C. D. A.</creatorcontrib><creatorcontrib>Henry, R. M. A.</creatorcontrib><title>Endothelial dysfunction is associated with a greater depressive symptom score in a general elderly population: the Hoorn Study</title><title>Psychological medicine</title><addtitle>Psychol. Med</addtitle><description>Endothelial dysfunction (ED), low-grade inflammation (LGI) and oxidative stress (OxS) may be involved in the pathobiology of depression. Previous studies on the association of these processes in depression have yielded contradictory results. We therefore investigated comprehensively, in a population-based cohort study, the association between ED, LGI and OxS on the one hand and depressive symptoms on the other.
We used data from the Hoorn Study and determined biomarkers of ED [flow-mediated dilatation (FMD), von Willebrand factor, soluble intercellular adhesion molecule 1 (sICAM-1), soluble vascular cell adhesion molecule 1, soluble thrombomodulin and soluble endothelial selectin], LGI [C-reactive protein, tumour necrosis factor-α, interleukin 6, interleukin 8, serum amyloid A, myeloperoxidase (MPO) and sICAM-1] and OxS (oxidized low density lipoprotein and MPO). Depressive symptoms were quantified by the Center for Epidemiologic Studies Depression Scale (CES-D) questionnaire (n = 493; age 68 years; 49.9% female). Regression analyses were performed with the use of biomarker Z scores. Adjustments were made for age, sex and glucose metabolism status (cohort stratification variables) and prior cardiovascular disease, hypertension, waist-to-hip ratio, cholesterol levels, education level, physical activity, dietary habits, and the use of antihypertensive and/or lipid-lowering medication and/or metformin (potential confounders).
After adjustment for age, sex and glucose metabolism status, one standard deviation increase in the ED Z score was associated with a 1.9 [95% confidence interval (CI) 0.7-3.1] higher CES-D score. Additional adjustments did not materially change this result. LGI and OxS were not associated with the CES-D score.
ED, as quantified by an array of circulating biomarkers and FMD, was independently associated with depressive symptoms. This study supports the hypothesis that ED plays an important role in the pathobiology of depression.</description><subject>Adjustment</subject><subject>Adult and adolescent clinical studies</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biological markers</subject><subject>Biology</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Blood vessels</subject><subject>Depression</subject><subject>Depression - epidemiology</subject><subject>Depression - etiology</subject><subject>Dysfunction</subject><subject>Endothelium, Vascular - physiopathology</subject><subject>Female</subject><subject>Glucose</subject><subject>Humans</subject><subject>Inflammation - blood</subject><subject>Inflammation - epidemiology</subject><subject>Inflammatory diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mental depression</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Mood disorders</subject><subject>Netherlands - epidemiology</subject><subject>Older people</subject><subject>Original Articles</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - physiology</subject><subject>Pathology</subject><subject>Psychology. 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T. ; Schram, M. T. ; Adriaanse, M. C. ; Dekker, J. M. ; Nijpels, G. ; Teerlink, T. ; Scheffer, P. G. ; Pouwer, F. ; Schalkwijk, C. G. ; Stehouwer, C. D. A. ; Henry, R. M. 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T.</au><au>Schram, M. T.</au><au>Adriaanse, M. C.</au><au>Dekker, J. M.</au><au>Nijpels, G.</au><au>Teerlink, T.</au><au>Scheffer, P. G.</au><au>Pouwer, F.</au><au>Schalkwijk, C. G.</au><au>Stehouwer, C. D. A.</au><au>Henry, R. M. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endothelial dysfunction is associated with a greater depressive symptom score in a general elderly population: the Hoorn Study</atitle><jtitle>Psychological medicine</jtitle><addtitle>Psychol. Med</addtitle><date>2014-05-01</date><risdate>2014</risdate><volume>44</volume><issue>7</issue><spage>1403</spage><epage>1416</epage><pages>1403-1416</pages><issn>0033-2917</issn><eissn>1469-8978</eissn><coden>PSMDCO</coden><abstract>Endothelial dysfunction (ED), low-grade inflammation (LGI) and oxidative stress (OxS) may be involved in the pathobiology of depression. Previous studies on the association of these processes in depression have yielded contradictory results. We therefore investigated comprehensively, in a population-based cohort study, the association between ED, LGI and OxS on the one hand and depressive symptoms on the other.
We used data from the Hoorn Study and determined biomarkers of ED [flow-mediated dilatation (FMD), von Willebrand factor, soluble intercellular adhesion molecule 1 (sICAM-1), soluble vascular cell adhesion molecule 1, soluble thrombomodulin and soluble endothelial selectin], LGI [C-reactive protein, tumour necrosis factor-α, interleukin 6, interleukin 8, serum amyloid A, myeloperoxidase (MPO) and sICAM-1] and OxS (oxidized low density lipoprotein and MPO). Depressive symptoms were quantified by the Center for Epidemiologic Studies Depression Scale (CES-D) questionnaire (n = 493; age 68 years; 49.9% female). Regression analyses were performed with the use of biomarker Z scores. Adjustments were made for age, sex and glucose metabolism status (cohort stratification variables) and prior cardiovascular disease, hypertension, waist-to-hip ratio, cholesterol levels, education level, physical activity, dietary habits, and the use of antihypertensive and/or lipid-lowering medication and/or metformin (potential confounders).
After adjustment for age, sex and glucose metabolism status, one standard deviation increase in the ED Z score was associated with a 1.9 [95% confidence interval (CI) 0.7-3.1] higher CES-D score. Additional adjustments did not materially change this result. LGI and OxS were not associated with the CES-D score.
ED, as quantified by an array of circulating biomarkers and FMD, was independently associated with depressive symptoms. This study supports the hypothesis that ED plays an important role in the pathobiology of depression.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>23942242</pmid><doi>10.1017/S0033291713002043</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Psychological medicine, 2014-05, Vol.44 (7), p.1403-1416 |
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| source | Applied Social Sciences Index & Abstracts (ASSIA); MEDLINE; Cambridge Journals |
| subjects | Adjustment Adult and adolescent clinical studies Aged Biological and medical sciences Biological markers Biology Biomarkers Biomarkers - blood Blood vessels Depression Depression - epidemiology Depression - etiology Dysfunction Endothelium, Vascular - physiopathology Female Glucose Humans Inflammation - blood Inflammation - epidemiology Inflammatory diseases Male Medical sciences Mental depression Metabolism Middle Aged Miscellaneous Mood disorders Netherlands - epidemiology Older people Original Articles Oxidative stress Oxidative Stress - physiology Pathology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry |
| title | Endothelial dysfunction is associated with a greater depressive symptom score in a general elderly population: the Hoorn Study |
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